Persistent phagocytic characteristics of microglia in the substantia nigra of long-term parkinsonian macaques

Journal of Neuroimmunology

Volumn 261, Issue 1-2, 2013, Pages 60-66

  Barcia, Carlos ^a,b   Ros, Carmen María ^a,b   Ros Bernal, Francisco ^a,b   Gómez, Aurora ^a,b   Annese, Valentina ^a,b   Carrillo de Sauvage, María Angeles ^a,b   Yuste, José Enrique ^a,b   Campuzano, Carmen María ^a   de Pablos, Vicente ^a,b   Fernández Villalba, Emiliano ^a,b   Herrero, María Trinidad ^a,b  

^a Clinical and Experimental Neuroscience ^*  (Spain)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

Cell polarity; DAPI; Dopaminergic degeneration; GM130; Iba 1; Inflammation; Microglial motility; MPTP; Parkinson's disease; PD; SNpc; TH

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL POLARITY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FEMALE; MACACA FASCICULARIS; MALE; MICROGLIA; NERVE DEGENERATION; NONHUMAN; PARKINSONISM; PHAGOCYTOSIS; PRIORITY JOURNAL; SUBSTANTIA NIGRA PARS COMPACTA;

1-METHYL-4-PHENYL-1,2,3,6 TETRAHYDROPYRIDINE; 4′,6-DIAMIDINO-2-PHENYLINDOLE; CELL POLARITY; CIS-GOLGI MATRIX PROTEIN 130; DAPI; DOPAMINERGIC DEGENERATION; GM130; IBA-1; INFLAMMATION; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; MICROGLIAL MOTILITY; MPTP; PARKINSON'S DISEASE; PD; SNPC; SUBSTANTIA NIGRA PARS COMPACTA; TH; TYROSINE HYDROXYLASE;

ANIMALS; FEMALE; MACACA FASCICULARIS; MALE; MICROGLIA; PARKINSON DISEASE; PHAGOCYTES; PHAGOCYTOSIS; SUBSTANTIA NIGRA; TIME FACTORS;

EID: 84880846013     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2013.05.001     Document Type: Article

References (20)

1. Barcia C., Bautista V., Sanchez-Bahillo A., Fernandez-Villalba E., Navarro-Ruis J.M., Barreiro A.F., et al. Circadian determinations of cortisol, prolactin and melatonin in chronic methyl-phenyl-tetrahydropyridine-treated monkeys. Neuroendocrinology 2003, 78:118-128.
2. Barcia C., Sanchez Bahillo A., Fernandez-Villalba E., Bautista V., Poza Y.P.M., Fernandez-Barreiro A., et al. Evidence of active microglia in substantia nigra pars compacta of Parkinsonian monkeys 1year after MPTP exposure. Glia 2004, 46:402-409.
3. Barcia C., Ros C.M., Annese V., Gomez A., Ros-Bernal F., Aguado-Yera D., et al. IFN-gamma signaling, with the synergistic contribution of TNF-alpha, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease. Cell Death Dis. 2011, 2:e142.
4. Barcia C., Ros C.M., Annese V., Carrillo-de Sauvage M.A., Ros-Bernal F., Gomez A., et al. ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo. Sci. Rep. 2012, 2:809.
5. Czlonkowska A., Kohutnicka M., Kurkowska-Jastrzebska I., Czlonkowski A. Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model. Neurodegeneration 1996, 5:137-143.
6. Damier P., Hirsch E.C., Agid Y., Graybiel A.M. The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain 1999, 122(Pt. 8):1437-1448.
7. Depboylu C., Stricker S., Ghobril J.P., Oertel W.H., Priller J., Hoglinge G.U. Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease. Exp. Neurol. 2012, 238:183-191.
8. Gibb W.R., Lees A.J. Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 1991, 54:388-396.
9. Gundersen H.J. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J. Microsc. 1986, 143:3-45.
10. Herrero M.T., Hirsch E.C., Kastner A., Ruberg M., Luquin M.R., Laguna J., et al. Does neuromelanin contribute to the vulnerability of catecholaminergic neurons in monkeys intoxicated with MPTP?. Neuroscience 1993, 56:499-511.
11. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
12. Langston J.W., Forno L.S., Tetrud J., Reeves A.G., Kaplan J.A., Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 1999, 46:598-605.
13. McGeer P.L., Itagaki S., Boyes B.E., McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291.
14. McGeer P.L., Schwab C., Parent A., Doudet D. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Ann. Neurol. 2003, 54:599-604.
15. Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
16. Olzewski J., Baxter D. Cytoarchitecture of the human brainstem 1954, S. Karger by J. B. Lippincott Company, Philadelphia and Montreal.
17. Paxinos G., Xu-Feng H., Toga A. The Rhesus Monkey Brain in Stereotaxic Coordinates 1999, Academic Press, San Diego.
18. Sierra A., Encinas J.M., Deudero J.J., Chancey J.H., Enikolopov G., Overstreet-Wadiche L.S., et al. Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 2010, 7:483-495.
19. Vazquez-Claverie M., Garrido-Gil P., San Sebastian W., Izal-Azcarate A., Belzunegui S., Marcilla I., et al. Acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administrations elicit similar microglial activation in the substantia nigra of monkeys. J. Neuropathol. Exp. Neurol. 2009, 68:977-984.
20. Yamada T., McGeer P., Baimbridge K., McGeer E. Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K. Brain Res. 1990, 526:303-307.