-
1
-
-
1542514783
-
Targeted histone deacetylase inhibition for cancer therapy
-
Vigushin DM, Coombes RC. (2004) Targeted histone deacetylase inhibition for cancer therapy. Curr Cancer Drug Targets 4: 205-218.
-
(2004)
Curr Cancer Drug Targets
, vol.4
, pp. 205-218
-
-
Vigushin, D.M.1
Coombes, R.C.2
-
2
-
-
0033539092
-
Structures of a histone deacetylase homo-logue bound to the TSA and SAHA inhibitors
-
Finnin MS, Donigian JR, Cohen A, Richon VM, Rifkind RA, Marks PA, Breslow R, Pavletich NP. (1999) Structures of a histone deacetylase homo-logue bound to the TSA and SAHA inhibitors. Nature 40: 188-193.
-
(1999)
Nature
, vol.40
, pp. 188-193
-
-
Finnin, M.S.1
Donigian, J.R.2
Cohen, A.3
Richon, V.M.4
Rifkind, R.A.5
Marks, P.A.6
Breslow, R.7
Pavletich, N.P.8
-
3
-
-
9144266953
-
Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors
-
Terui T, Murakami K, Takimoto R, Takahashi M, Takada K, Murakami T, Minami S, Matsunaga T, Takayama T, Kato J, Niitsu Y. (2003) Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors. Cancer Res 63: 8948-8954.
-
(2003)
Cancer Res
, vol.63
, pp. 8948-8954
-
-
Terui, T.1
Murakami, K.2
Takimoto, R.3
Takahashi, M.4
Takada, K.5
Murakami, T.6
Minami, S.7
Matsunaga, T.8
Takayama, T.9
Kato, J.10
Niitsu, Y.11
-
4
-
-
0033199896
-
Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma
-
Glick RD, Swendeman SL, Coffey DC, Rifkind RA, Marks PA, Richon VM, La Quaglia MP. (1999) Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Res 59: 4392-4399.
-
(1999)
Cancer Res
, vol.59
, pp. 4392-4399
-
-
Glick, R.D.1
Swendeman, S.L.2
Coffey, D.C.3
Rifkind, R.A.4
Marks, P.A.5
Richon, V.M.6
La Quaglia, M.P.7
-
5
-
-
18544367699
-
Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells
-
Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW, Han JW. (2002) Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J Biol Chem 277: 2073-2080.
-
(2002)
J Biol Chem
, vol.277
, pp. 2073-2080
-
-
Kwon, S.H.1
Ahn, S.H.2
Kim, Y.K.3
Bae, G.U.4
Yoon, J.W.5
Hong, S.6
Lee, H.Y.7
Lee, Y.W.8
Lee, H.W.9
Han, J.W.10
-
6
-
-
0030772026
-
Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line
-
Nakano K, Mizuno T, Sowa Y, Orita T, Yoshino T, Okuyama Y, Fujita T, Ohtani-Fujita N, Matsukawa Y, Tokino T, Yamagishi H, Oka T, Nomura H, Sakai T. (1997) Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J Biol Chem 272: 22199-22206.
-
(1997)
J Biol Chem
, vol.272
, pp. 22199-22206
-
-
Nakano, K.1
Mizuno, T.2
Sowa, Y.3
Orita, T.4
Yoshino, T.5
Okuyama, Y.6
Fujita, T.7
Ohtani-Fujita, N.8
Matsukawa, Y.9
Tokino, T.10
Yamagishi, H.11
Oka, T.12
Nomura, H.13
Sakai, T.14
-
7
-
-
17744416444
-
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites
-
Sowa Y, Orita T, Minamikawa S, Nakano K, Mizuno T, Nomura H, Skai T. (1997) Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem Biophys Res Commun 241: 142-150.
-
(1997)
Biochem Biophys Res Commun
, vol.241
, pp. 142-150
-
-
Sowa, Y.1
Orita, T.2
Minamikawa, S.3
Nakano, K.4
Mizuno, T.5
Nomura, H.6
Skai, T.7
-
8
-
-
0842277812
-
Histone deacety-lase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1
-
Gui CV, Ngo L, Xu WS, Richon VM, Marks PA. (2004) Histone deacety-lase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1. Proc Natl Acad Sci USA 101: 1241-1246.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 1241-1246
-
-
Gui, C.V.1
Ngo, L.2
Xu, W.S.3
Richon, V.M.4
Marks, P.A.5
-
9
-
-
0038676409
-
Inhibition of histone deacetylase activity by butyrate
-
Davie JR. (2003) Inhibition of histone deacetylase activity by butyrate. J Nutr 133: 2485S-2493S.
-
(2003)
J Nutr
, vol.133
-
-
Davie, J.R.1
-
10
-
-
0035933575
-
Genes modulated by histone acetylation as new effectors of butyrate activity
-
Della Ragione F, Criniti V, Della Pietra V, Borriello A, Oliva A, Indaco S, Yamamoto T, Zappia V. (2001) Genes modulated by histone acetylation as new effectors of butyrate activity. FEBS Lett 499: 199-204.
-
(2001)
FEBS Lett
, vol.499
, pp. 199-204
-
-
Della Ragione, F.1
Criniti, V.2
Della Pietra, V.3
Borriello, A.4
Oliva, A.5
Indaco, S.6
Yamamoto, T.7
Zappia, V.8
-
11
-
-
0036939240
-
Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression
-
Finzer P, Ventz R, Kuntzen C, Seibert N, Soto U, Rosl F. (2002) Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression. Virology 304: 265-273.
-
(2002)
Virology
, vol.304
, pp. 265-273
-
-
Finzer, P.1
Ventz, R.2
Kuntzen, C.3
Seibert, N.4
Soto, U.5
Rosl, F.6
-
12
-
-
18644367141
-
Induction and superinduction of growth arrest and DNA damage gene45(GADD45) alpha and beta messenger RNAs by histone deactylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells
-
Chen Z, Clark S, Birkeland M, Sung CM, Lago A, Liu R, Kirkpatrick R, Johnanson K, Winkler JD, Hu E. (2002) Induction and superinduction of growth arrest and DNA damage gene45(GADD45) alpha and beta messenger RNAs by histone deactylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells. Cancer Lett 188: 127-140.
-
(2002)
Cancer Lett
, vol.188
, pp. 127-140
-
-
Chen, Z.1
Clark, S.2
Birkeland, M.3
Sung, C.M.4
Lago, A.5
Liu, R.6
Kirkpatrick, R.7
Johnanson, K.8
Winkler, J.D.9
Hu, E.10
-
13
-
-
0036252352
-
The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation
-
Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA. (2002) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132: 1012-1017.
-
(2002)
J Nutr
, vol.132
, pp. 1012-1017
-
-
Hinnebusch, B.F.1
Meng, S.2
Wu, J.T.3
Archer, S.Y.4
Hodin, R.A.5
-
14
-
-
0033740191
-
Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells
-
Davis T, Kennedy C, Chiew YE, Clarke CL, deFaxio A. (2000) Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clin Cancer Res 6: 4334-4342.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4334-4342
-
-
Davis, T.1
Kennedy, C.2
Chiew, Y.E.3
Clarke, C.L.4
Defaxio, A.5
-
15
-
-
0035837658
-
Paradoxical effects of trichostatin A: Inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and down-regulation of cyclin A and B1 mRNA
-
Nair AR, Boersma LJ, Schilz L, Chaudhry MA, Muschel RJ, Chaudry A. (2001) Paradoxical effects of trichostatin A: Inhibition of NF-Y-associated histone acetyltransferase activity, phosphorylation of hGCN5 and down-regulation of cyclin A and B1 mRNA. Cancer Lett 166: 55-64.
-
(2001)
Cancer Lett
, vol.166
, pp. 55-64
-
-
Nair, A.R.1
Boersma, L.J.2
Schilz, L.3
Chaudhry, M.A.4
Muschel, R.J.5
Chaudry, A.6
-
16
-
-
0029693220
-
The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
-
Van Lint C, Emiliani S, Verdin E. (1996) The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expression 5: 245-253.
-
(1996)
Gene Expression
, vol.5
, pp. 245-253
-
-
Van Lint, C.1
Emiliani, S.2
Verdin, E.3
-
17
-
-
0032729215
-
Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts
-
Bernhard D, Ausserlechner MJ, Tonko M, Loffler M, Hartmann BL, Csordas A, Kofler R. (1999) Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts. FASEB J 13: 1991-2001.
-
(1999)
FASEB J
, vol.13
, pp. 1991-2001
-
-
Bernhard, D.1
Ausserlechner, M.J.2
Tonko, M.3
Loffler, M.4
Hartmann, B.L.5
Csordas, A.6
Kofler, R.7
-
18
-
-
0020693603
-
Effect of polar organic compounds on leukemic cells. Butyrate-induced partial remission of acute myelogenous leukemia in a child
-
Novogrodsky A, Dvir A, Ravid A, Shkolnik T, Stenzel KH, Rubin AL, Zaizov R. (1983) Effect of polar organic compounds on leukemic cells. Butyrate-induced partial remission of acute myelogenous leukemia in a child. Cancer 51: 9-14.
-
(1983)
Cancer
, vol.51
, pp. 9-14
-
-
Novogrodsky, A.1
Dvir, A.2
Ravid, A.3
Shkolnik, T.4
Stenzel, K.H.5
Rubin, A.L.6
Zaizov, R.7
-
19
-
-
31544481927
-
Histone deacetylases as targets for dietary cancer preventive agents: Lessons learned with butyrate, diallyl disulfide, and sulforaphane
-
Myzak MC, Dashwood RH. (2006) Histone deacetylases as targets for dietary cancer preventive agents: Lessons learned with butyrate, diallyl disulfide, and sulforaphane. Current Drug Targets 7: 443-452.
-
(2006)
Current Drug Targets
, vol.7
, pp. 443-452
-
-
Myzak, M.C.1
Dashwood, R.H.2
-
20
-
-
0035000305
-
Transient vs. Prolonged histone hyperacetylation: Effects on colon cancer cell growth, differentiation, and apoptosis
-
Wu JT, Archer SY, Hinnebusch B, Meng S, Hodin RA. (2001) Transient vs. prolonged histone hyperacetylation: Effects on colon cancer cell growth, differentiation, and apoptosis. Am J Physiol Gastrointest Liver Physiol 280: G482-G490.
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.280
, pp. G482-G490
-
-
Wu, J.T.1
Archer, S.Y.2
Hinnebusch, B.3
Meng, S.4
Hodin, R.A.5
-
21
-
-
0035165096
-
Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, BAX, p21 and PCNA protein expression in an in vitro cell culture model
-
Emenaker NJ, Calaf GM, Cox D, Basson MD, Qureshi N. (2001) Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, BAX, p21 and PCNA protein expression in an in vitro cell culture model. JNutr 131: 3041S-3046S.
-
(2001)
Jnutr
, vol.131
-
-
Emenaker, N.J.1
Calaf, G.M.2
Cox, D.3
Basson, M.D.4
Qureshi, N.5
-
22
-
-
7244256107
-
Butyrate reduces liver metastasis of rat colon carcinoma cells in vivo and resistance to oxidative stress in vivo
-
Li X, Mikkelsen IM, Mortensen B, Winberg JO, Huseby NE. (2004) Butyrate reduces liver metastasis of rat colon carcinoma cells in vivo and resistance to oxidative stress in vivo. Clin Exp Metastasis 21: 331-338.
-
(2004)
Clin Exp Metastasis
, vol.21
, pp. 331-338
-
-
Li, X.1
Mikkelsen, I.M.2
Mortensen, B.3
Winberg, J.O.4
Huseby, N.E.5
-
23
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone RW. (2002) Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer. Nat Rev Drug Discov 1: 287-299.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
24
-
-
3042615204
-
Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis
-
Guyonnet D, Berges R, Siess MH, Pinnert MF, Chagnon MC, Suschetet M, Le Bon AM. (2004) Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis. Food Chem Toxicol 42: 1479-1485.
-
(2004)
Food Chem Toxicol
, vol.42
, pp. 1479-1485
-
-
Guyonnet, D.1
Berges, R.2
Siess, M.H.3
Pinnert, M.F.4
Chagnon, M.C.5
Suschetet, M.6
Le Bon, A.M.7
-
25
-
-
0033173102
-
Increased acetylation of histones induced by diallyl disulfide and structurally related molecules
-
Lea MA, Randolph VM, Patel M. (1999) Increased acetylation of histones induced by diallyl disulfide and structurally related molecules. Int J Oncol 15: 347-352.
-
(1999)
Int J Oncol
, vol.15
, pp. 347-352
-
-
Lea, M.A.1
Randolph, V.M.2
Patel, M.3
-
26
-
-
0035156867
-
Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide
-
Lea MA, Randolph VM. (2001) Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide. Anticancer Res 21: 2841-2845.
-
(2001)
Anticancer Res
, vol.21
, pp. 2841-2845
-
-
Lea, M.A.1
Randolph, V.M.2
-
27
-
-
72249122960
-
Dietary Sulforaphane, a histone deacetylase inhibitor for cancer prevention
-
Ho E, Clarke JD, Dashwood RH. (2009) Dietary Sulforaphane, a histone deacetylase inhibitor for cancer prevention. J Nutr 139: 2393-2396.
-
(2009)
J Nutr
, vol.139
, pp. 2393-2396
-
-
Ho, E.1
Clarke, J.D.2
Dashwood, R.H.3
-
28
-
-
3242755145
-
Dially disulfide (DADS) increase histone acetylation and p21/waf1/cip1 expression in human colon tumor cell lines
-
Druesne N, Pagniez A, Mayeur C, Thomas M, Cherbuy C, Duee PH, Martel P, Chaumontet C. (2004) Dially disulfide (DADS) increase histone acetylation and p21/waf1/cip1 expression in human colon tumor cell lines. Carcinogenesis 25: 1227-1236.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1227-1236
-
-
Druesne, N.1
Pagniez, A.2
Mayeur, C.3
Thomas, M.4
Cherbuy, C.5
Duee, P.H.6
Martel, P.7
Chaumontet, C.8
-
29
-
-
0036437194
-
Induction of histone acetylation and inhibition of growth of mouse erythroleukemai cells by S-allylmercaptocysteine
-
Lea MA, Rasheed M, Randolph VM, Khan F, Shareef A, desBordes C. (2002) Induction of histone acetylation and inhibition of growth of mouse erythroleukemai cells by S-allylmercaptocysteine. Nutr Cancer 43: 90-102.
-
(2002)
Nutr Cancer
, vol.43
, pp. 90-102
-
-
Lea, M.A.1
Rasheed, M.2
Randolph, V.M.3
Khan, F.4
Shareef, A.5
Desbordes, C.6
-
30
-
-
34548269577
-
Feijoa sellowiana derived natural flavone exerts anti-cancer action displaying HDAC inhibitory activities
-
Bontempo P, Milta L, Miceli M, Doto A, Nebbioso A, De Bellis F, Conte M, Minichiello A, Manzo F, Carafa V, Basile A, Rigano D, Sorbo S, Cobianchi RC, Schiavone EM, Ferrara F, De Simone M, Vietri MT, Cioffi M, Sica V, Bresciani F, de Lera AR, Altucci L, Molinari AM. (2007) Feijoa sellowiana derived natural flavone exerts anti-cancer action displaying HDAC inhibitory activities. Int J Biochem Cell Biol 39: 1902-1914.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 1902-1914
-
-
Bontempo, P.1
Milta, L.2
Miceli, M.3
Doto, A.4
Nebbioso, A.5
De Bellis, F.6
Conte, M.7
Minichiello, A.8
Manzo, F.9
Carafa, V.10
Basile, A.11
Rigano, D.12
Sorbo, S.13
Cobianchi, R.C.14
Schiavone, E.M.15
Ferrara, F.16
De Simone, M.17
Vietri, M.T.18
Cioffi, M.19
Sica, V.20
Bresciani, F.21
De Lera, A.R.22
Altucci, L.23
Molinari, A.M.24
more..
-
31
-
-
0141885036
-
Novel hydrozmate and anilide derivatives as potent histone deacetylase inhibitors: Synthesis and antiproliferative evaluation
-
Bouchain G, Delorme D. (2003) Novel hydrozmate and anilide derivatives as potent histone deacetylase inhibitors: Synthesis and antiproliferative evaluation. Curr Med Chem 10: 2359-2372.
-
(2003)
Curr Med Chem
, vol.10
, pp. 2359-2372
-
-
Bouchain, G.1
Delorme, D.2
-
33
-
-
28444463674
-
Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris maclaccensis
-
Svasti J, Srisomsap C, Subhasitanont P, Keeratichamroen S, Chokchaichamnankit D, Ngiwsara L, Chimnoi N, Pisutjaroenpong S, Techasakul S, Chen ST. (2005) Proteomic profiling of cholangiocarcinoma cell line treated with pomiferin from Derris maclaccensis. Proteomics 5: 4504-4509.
-
(2005)
Proteomics
, vol.5
, pp. 4504-4509
-
-
Svasti, J.1
Srisomsap, C.2
Subhasitanont, P.3
Keeratichamroen, S.4
Chokchaichamnankit, D.5
Ngiwsara, L.6
Chimnoi, N.7
Pisutjaroenpong, S.8
Techasakul, S.9
Chen, S.T.10
-
34
-
-
0346433748
-
Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid
-
Tsao R, Yang R, Young JC. (2003) Antioxidant isoflavones in Osage orange, Maclura pomifera (Raf.) Schneid. J Agric Food Chem 51: 6445-6451.
-
(2003)
J Agric Food Chem
, vol.51
, pp. 6445-6451
-
-
Tsao, R.1
Yang, R.2
Young, J.C.3
-
35
-
-
0019488061
-
Antimicrobial components from Maclura pomifera fruit
-
Mahmoud ZF. (1981) Antimicrobial components from Maclura pomifera fruit. Planta Med 42: 299-301.
-
(1981)
Planta Med
, vol.42
, pp. 299-301
-
-
Mahmoud, Z.F.1
-
36
-
-
34547529740
-
Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera
-
Son IH, Chung IM, Lee SI, Yang HD, Moon HI. (2007) Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett 17: 4753-4755.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 4753-4755
-
-
Son, I.H.1
Chung, I.M.2
Lee, S.I.3
Yang, H.D.4
Moon, H.I.5
-
37
-
-
0034525122
-
Chemoprevention of colonic aberrant crypt foci in Fisher rats by sulfroraphane and phenethyl isothiocyanate
-
Chung IL, Conaway CC, Rao CV, Reddy BS. (2000) Chemoprevention of colonic aberrant crypt foci in Fisher rats by sulfroraphane and phenethyl isothiocyanate. Carcinogenesis 21: 2287-2291.
-
(2000)
Carcinogenesis
, vol.21
, pp. 2287-2291
-
-
Chung, I.L.1
Conaway, C.C.2
Rao, C.V.3
Reddy, B.S.4
-
38
-
-
0030931522
-
Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
-
Fahey JW, Zhang Y, Talalay P. (1997) Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci USA 94: 10367-10372.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10367-10372
-
-
Fahey, J.W.1
Zhang, Y.2
Talalay, P.3
-
39
-
-
0037093463
-
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate
-
Zhang Y, Callaway EC. (2002) High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J 364: 301-307.
-
(2002)
Biochem J
, vol.364
, pp. 301-307
-
-
Zhang, Y.1
Callaway, E.C.2
-
40
-
-
0030781225
-
Biotransformation of the naturally occurring isothiocyante sulforaphane in the rat: Identification of phase I metabolities and glutathione conjugates
-
Kassahun K, Davis M, Hu P, Martin B, Baillie T. (1997) Biotransformation of the naturally occurring isothiocyante sulforaphane in the rat: Identification of phase I metabolities and glutathione conjugates. Chem Res Toxicol 10: 1228-1233.
-
(1997)
Chem Res Toxicol
, vol.10
, pp. 1228-1233
-
-
Kassahun, K.1
Davis, M.2
Hu, P.3
Martin, B.4
Baillie, T.5
-
41
-
-
4143130097
-
A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
-
Myzak MC, Karplus PA, Chung FL, Dashwood RH. (2004) A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase. Cancer Res 64: 5767-5774.
-
(2004)
Cancer Res
, vol.64
, pp. 5767-5774
-
-
Myzak, M.C.1
Karplus, P.A.2
Chung, F.L.3
Dashwood, R.H.4
-
42
-
-
58549090733
-
Sulforaphanc induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependant pathway in murine hepatoma Hepa Iclc7 and human Hep62 cells
-
Anwar-Mohamed A, El-Kadi, AOS. (2009) Sulforaphanc induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependant pathway in murine hepatoma Hepa Iclc7 and human Hep62 cells. Cancer Lett 275: 93-101.
-
(2009)
Cancer Lett
, vol.275
, pp. 93-101
-
-
Anwar-Mohamed, A.1
El-Kadi, A.O.S.2
-
43
-
-
63049105405
-
Modulation of histone deacetylase activity by dietary isothio-cyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds
-
Nian H, Delage B, Ho E, Dashwood RH. (2009) Modulation of histone deacetylase activity by dietary isothio-cyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds. Environ Mol Mutagen 50: 213-221.
-
(2009)
Environ Mol Mutagen
, vol.50
, pp. 213-221
-
-
Nian, H.1
Delage, B.2
Ho, E.3
Dashwood, R.H.4
-
44
-
-
34147135143
-
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
-
Pledgie-Tracy A, Sobolewski MD, Davidson NE. (2007) Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther 6: 1013-1021.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1013-1021
-
-
Pledgie-Tracy, A.1
Sobolewski, M.D.2
Davidson, N.E.3
-
45
-
-
38449089515
-
Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo
-
Matsui TA, Murata H, Sakabe T, Sowa Y, Horie N, Nakanishi R, Sakai T, Kubo T. (2007) Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. Oncol Rep 18: 1263-1268.
-
(2007)
Oncol Rep
, vol.18
, pp. 1263-1268
-
-
Matsui, T.A.1
Murata, H.2
Sakabe, T.3
Sowa, Y.4
Horie, N.5
Nakanishi, R.6
Sakai, T.7
Kubo, T.8
-
46
-
-
33846838750
-
Sulforaphane retards the growth of human PC-3 xenographs and inhibits HDAC activity in human subjects
-
Myzak MC, Tong P, Dashwood WM, Dashwood RH, Ho E. (2007) Sulforaphane retards the growth of human PC-3 xenographs and inhibits HDAC activity in human subjects. Exp Biol Med 232: 227-234.
-
(2007)
Exp Biol Med
, vol.232
, pp. 227-234
-
-
Myzak, M.C.1
Tong, P.2
Dashwood, W.M.3
Dashwood, R.H.4
Ho, E.5
-
47
-
-
1642545614
-
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
-
Singh AV, Xiao D, Lew KL, Dhir R, Singh SV. (2004) Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis 25: 83-90.
-
(2004)
Carcinogenesis
, vol.25
, pp. 83-90
-
-
Singh, A.V.1
Xiao, D.2
Lew, K.L.3
Dhir, R.4
Singh, S.V.5
-
48
-
-
0028203252
-
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
-
Zhang Y, Kensler TW, Cho CG, Posner GH, Tallalay P. (1994) Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci USA 91: 3147-3150.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3147-3150
-
-
Zhang, Y.1
Kensler, T.W.2
Cho, C.G.3
Posner, G.H.4
Tallalay, P.5
-
49
-
-
33645825587
-
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorige-nesis in Apc-minus mice
-
Myzak MC, Dashwood WM, Orner GA, Ho E, Dashwood, RH. (2006) Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorige-nesis in Apc-minus mice. FASEB J 20: 506-8.
-
(2006)
FASEB J
, vol.20
, pp. 506-508
-
-
Myzak, M.C.1
Dashwood, W.M.2
Orner, G.A.3
Ho, E.4
Dashwood, R.H.5
-
50
-
-
33845199114
-
Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine spong Mycale izuensis
-
Nakao Y, Yoshida S, Matsunaga S, Shindoh N, Terada Y, Nagai K, Yamashita JK, Ganesan A, van Soest RWM, Fusetani N. (2006) Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine spong Mycale izuensis. Angew Chem Int Ed 45: 7553-7557.
-
(2006)
Angew Chem Int Ed
, vol.45
, pp. 7553-7557
-
-
Nakao, Y.1
Yoshida, S.2
Matsunaga, S.3
Shindoh, N.4
Terada, Y.5
Nagai, K.6
Yamashita, J.K.7
Ganesan, A.8
Van Soest, R.9
Fusetani, N.10
-
52
-
-
0007247909
-
Cycloenantiomerism, and cyclodias-teromerism
-
Prelog IV, Gerlach H. (1964) Cycloenantiomerism, and cyclodias-teromerism. Helv Chim Acta 47: 2288-2294.
-
(1964)
Helv Chim Acta
, vol.47
, pp. 2288-2294
-
-
Prelog, I.V.1
Gerlach, H.2
-
53
-
-
33845560283
-
On the concept of linear modified retro-peptide structures
-
Goodman M, Chorev M. (1979) On the concept of linear modified retro-peptide structures. Acc Chem Res 12: 1-7.
-
(1979)
Acc Chem Res
, vol.12
, pp. 1-7
-
-
Goodman, M.1
Chorev, M.2
-
54
-
-
33947239221
-
Molecular insights into azumamide E histone deacetylases inhibitory activity
-
Maulucci N, Chini MC, Di Micco S, Izzo I, Cafaro E, Russo A, Gallinari P, Paolini C, Nardi MC, Casapullo A, Riccio R, Bifulco G De Riccardis F. (2007) Molecular insights into azumamide E histone deacetylases inhibitory activity. J Am Chem Soc 129: 3007-3012.
-
(2007)
J am Chem Soc
, vol.129
, pp. 3007-3012
-
-
Maulucci, N.1
Chini, M.C.2
Di Micco, S.3
Izzo, I.4
Cafaro, E.5
Russo, A.6
Gallinari, P.7
Paolini, C.8
Nardi, M.C.9
Casapullo, A.10
Riccio, R.11
Bifulco, G.12
De Riccardis, F.13
-
55
-
-
0035931464
-
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 2
-
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT. (2001) Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 2. Bioorg Med Chem Lett 11: 113-117.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, pp. 113-117
-
-
Colletti, S.L.1
Myers, R.W.2
Darkin-Rattray, S.J.3
Gurnett, A.M.4
Dulski, P.M.5
Galuska, S.6
Allocco, J.J.7
Ayer, M.B.8
Li, C.9
Lim, J.10
Crumley, T.M.11
Cannova, C.12
Schmatz, D.M.13
Wyvratt, M.J.14
Fisher, M.H.15
Meinke, P.T.16
-
56
-
-
0035793107
-
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
-
Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S. (2001) Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci USA 98: 87-92.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 87-92
-
-
Furumai, R.1
Komatsu, Y.2
Nishino, N.3
Khochbin, S.4
Yoshida, M.5
Horinouchi, S.6
-
57
-
-
21844495631
-
Relationships between structural features and biological activities of HC-toxin
-
Kim SD. (1995) Relationships between structural features and biological activities of HC-toxin. J Biochem Mol Biol 28: 227-231.
-
(1995)
J Biochem Mol Biol
, vol.28
, pp. 227-231
-
-
Kim, S.D.1
-
58
-
-
0028365944
-
Bioactive marine metabolities. 59. Cyclostellettamines A-F, pyridine alkaloids which inhibit binding of methyl quinuclidinyl benzylate (QNB) to muscarinic acetylcholine receptors, from the marine sponge, Stelletta maxima
-
Fusetani N, Asai N, Matsunaga S, Honda K, Yasumuro K. (1994) Bioactive marine metabolities. 59. Cyclostellettamines A-F, pyridine alkaloids which inhibit binding of methyl quinuclidinyl benzylate (QNB) to muscarinic acetylcholine receptors, from the marine sponge, Stelletta maxima. Tetrahedron Lett 35: 3967-3970.
-
(1994)
Tetrahedron Lett
, vol.35
, pp. 3967-3970
-
-
Fusetani, N.1
Asai, N.2
Matsunaga, S.3
Honda, K.4
Yasumuro, K.5
-
59
-
-
1942438219
-
Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia
-
Oku N, Nagai K, Shindoh N, Terada Y, Van Soest RWM, Matsunaga S, Fusetani N. (2004) Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Biorg Med Chem Lett 14: 2617-2620.
-
(2004)
Biorg Med Chem Lett
, vol.14
, pp. 2617-2620
-
-
Oku, N.1
Nagai, K.2
Shindoh, N.3
Terada, Y.4
Van Soest, R.5
Matsunaga, S.6
Fusetani, N.7
-
60
-
-
7044262248
-
Ingenamine G and cyclostellettamines G-I, K, and L from the new Brazilian species of marine sponge Pachychalina sp
-
De Oliveira JHHL, Grube A, Koeck M, Berlinck RGS, Macedo ML, Ferreira AG, Hajdu E. (2004) Ingenamine G and cyclostellettamines G-I, K, and L from the new Brazilian species of marine sponge Pachychalina sp. J Nat Prod 67: 1685-1689.
-
(2004)
J Nat Prod
, vol.67
, pp. 1685-1689
-
-
De Oliveira, J.1
Grube, A.2
Koeck, M.3
Berlinck, R.4
Macedo, M.L.5
Ferreira, A.G.6
Hajdu, E.7
-
61
-
-
34249081115
-
Bispyridinium dienes: Histone deacetylase inhibitors with selective activities
-
Perez-Balado C, Nebbioso A, Rodriguez-Grana P, Minichiello A, Miceli M, Altucci L, de Lera AR. (2007) Bispyridinium dienes: Histone deacetylase inhibitors with selective activities. J Med Chem 50: 2497-2505.
-
(2007)
J Med Chem
, vol.50
, pp. 2497-2505
-
-
Perez-Balado, C.1
Nebbioso, A.2
Rodriguez-Grana, P.3
Minichiello, A.4
Miceli, M.5
Altucci, L.6
De Lera, A.R.7
-
62
-
-
0000055673
-
Phenolic constituent of Psammaplysilla
-
Quinoa E, Crews P. (1987) Phenolic constituent of Psammaplysilla Tetrahedron Lett 28: 3229-3232.
-
(1987)
Tetrahedron Lett
, vol.28
, pp. 3229-3232
-
-
Quinoa, E.1
Crews, P.2
-
63
-
-
37349061341
-
A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells
-
Ahn MY, Jung JH, Na YJ, Kim HS. (2008) A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells. Gynecol Oncol 108: 27-33.
-
(2008)
Gynecol Oncol
, vol.108
, pp. 27-33
-
-
Ahn, M.Y.1
Jung, J.H.2
Na, Y.J.3
Kim, H.S.4
-
64
-
-
62149098372
-
Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives
-
McCulloch MWB, Coombs GS, Banerjee N, Bugni TS, Cannon KM, Harper MK, Veltri CA, Virshup DM. (2009) Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorg Med Chem 17: 2189-2198.
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 2189-2198
-
-
Mc Culloch, M.1
Coombs, G.S.2
Banerjee, N.3
Bugni, T.S.4
Cannon, K.M.5
Harper, M.K.6
Veltri, C.A.7
Virshup, D.M.8
-
65
-
-
0038627550
-
Psammaplins from the sponge Pseudoceratina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase
-
Pina IC, Gautschi JT, Wang GYSW, Sanders ML, Schmitz FJ, France D, Cornell-Kennon S, Sambucetti LC, Remiszewski SW, Perex LB, Bair KW, Crews P (2003) Psammaplins from the sponge Pseudoceratina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase. J Org Chem 68: 3866-3873.
-
(2003)
J Org Chem
, vol.68
, pp. 3866-3873
-
-
Pina, I.C.1
Gautschi, J.T.2
Wang, G.3
Sanders, M.L.4
Schmitz, F.J.5
France, D.6
Cornell-Kennon, S.7
Sambucetti, L.C.8
Remiszewski, S.W.9
Perex, L.B.10
Bair, K.W.11
Crews, P.12
-
66
-
-
0037039919
-
Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal a-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities
-
Singh SB, Zink DL, Liesch JM, Mosley RT, Dombrowski AW, Bills GF, Darkin-Rattray SJ, Schmatz DM, Goetz MA. (2002) Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal a-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities. J Org Chem 67: 815-825.
-
(2002)
J Org Chem
, vol.67
, pp. 815-825
-
-
Singh, S.B.1
Zink, D.L.2
Liesch, J.M.3
Mosley, R.T.4
Dombrowski, A.W.5
Bills, G.F.6
Darkin-Rattray, S.J.7
Schmatz, D.M.8
Goetz, M.A.9
-
67
-
-
42049103914
-
From natural products to small molecule ketone histone deacetylase inhibitors: Development of new class specific agents
-
Jones P, Steinkuhler C. (2008) From natural products to small molecule ketone histone deacetylase inhibitors: Development of new class specific agents. Curr Pharm Des 14: 545-561.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 545-561
-
-
Jones, P.1
Steinkuhler, C.2
-
68
-
-
0016366116
-
Isolation and structural clarification of chlamydocin
-
Closse A, Hugenin R. (1974) Isolation and structural clarification of chlamydocin. Helv Chim Acta 57: 533-545.
-
(1974)
Helv Chim Acta
, vol.57
, pp. 533-545
-
-
Closse, A.1
Hugenin, R.2
-
69
-
-
35348816926
-
Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework
-
Shivashimpi GM, Amagai S, Kato T, Nishino N, Maeda S, Nishino TG, Yoshida M. (2007) Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework. Bioorg Med Chem 15: 7830-7839.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 7830-7839
-
-
Shivashimpi, G.M.1
Amagai, S.2
Kato, T.3
Nishino, N.4
Maeda, S.5
Nishino, T.G.6
Yoshida, M.7
-
70
-
-
6344247464
-
Chlamydocin-hydroxamic acid analogues as histone deacetylase inhibitors
-
Nishino N, Jose B, Shinta R, Kato T, Komatsu Y, Yoshida M. (2004) Chlamydocin-hydroxamic acid analogues as histone deacetylase inhibitors. Bioorg Med Chem 12: 5777-5784.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 5777-5784
-
-
Nishino, N.1
Jose, B.2
Shinta, R.3
Kato, T.4
Komatsu, Y.5
Yoshida, M.6
-
71
-
-
33645892015
-
Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases
-
Bhuiyan MPI, Kato T, Okauchi T, Nishino N, Mueda S, Nishino TG, Yoshida M. (2006) Chlamydocin analogs bearing carbonyl group as possible ligand toward zinc atom in histone deacetylases. Bioorg Med Chem Lett 14: 3438-3446.
-
(2006)
Bioorg Med Chem Lett
, vol.14
, pp. 3438-3446
-
-
Bhuiyan, M.1
Kato, T.2
Okauchi, T.3
Nishino, N.4
Mueda, S.5
Nishino, T.G.6
Yoshida, M.7
-
72
-
-
0037300444
-
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits ammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities
-
Mori H, Urano Y, Abe F, Furukawa S, Tsurumi Y, Sakamoto K, Hashimoto M, Takase S, Hino M, Fujii T. (2003) FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits ammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities. J Antibiot 56: 72-79.
-
(2003)
J Antibiot
, vol.56
, pp. 72-79
-
-
Mori, H.1
Urano, Y.2
Abe, F.3
Furukawa, S.4
Tsurumi, Y.5
Sakamoto, K.6
Hashimoto, M.7
Takase, S.8
Hino, M.9
Fujii, T.10
-
73
-
-
65549088044
-
Drug inhibition of HDAC3 and epigenetic control of differentiation in apicomplexa parasites
-
Bougdour A, Maubon D, Baldacci P, Ortet P, Bastien O, Bouillon A, Barale JC, Pelloux H, Menard R, Hakimi MA. (2009) Drug inhibition of HDAC3 and epigenetic control of differentiation in apicomplexa parasites. J Exper Med 206: 953-966.
-
(2009)
J Exper Med
, vol.206
, pp. 953-966
-
-
Bougdour, A.1
Maubon, D.2
Baldacci, P.3
Ortet, P.4
Bastien, O.5
Bouillon, A.6
Barale, J.C.7
Pelloux, H.8
Menard, R.9
Hakimi, M.A.10
-
74
-
-
0029411482
-
Inhibition of maize histone deacetylases by HC Toxin, the host-selective toxin of cochliobolus carbonum
-
Brosch G, Ransom R, Lechner T, Walton JD, Loidl P. (1995) Inhibition of maize histone deacetylases by HC Toxin, the host-selective toxin of cochliobolus carbonum. Plant Cell 7: 1941-1950.
-
(1995)
Plant Cell
, vol.7
, pp. 1941-1950
-
-
Brosch, G.1
Ransom, R.2
Lechner, T.3
Walton, J.D.4
Loidl, P.5
-
75
-
-
17344366283
-
Antiproliferative effect of Trichostatin A and HC-Toxin in T47D Human Breast Cancer Cells
-
Joung KE, Kim DK, Shenn YY. (2004) Antiproliferative effect of Trichostatin A and HC-Toxin in T47D Human Breast Cancer Cells. Arch Pharm Res 27: 640-645.
-
(2004)
Arch Pharm Res
, vol.27
, pp. 640-645
-
-
Joung, K.E.1
Kim, D.K.2
Shenn, Y.Y.3
-
76
-
-
42649106134
-
Antineuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro
-
Deubzer HE, Ehemann V, Kulozik AE, Westermann F, Savelyeva L, Kopp-Schneider A, Riester D, Schwab M, Witt O. (2008) Antineuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro. Cancer Lett 264: 21-28.
-
(2008)
Cancer Lett
, vol.264
, pp. 21-28
-
-
Deubzer, H.E.1
Ehemann, V.2
Kulozik, A.E.3
Westermann, F.4
Savelyeva, L.5
Kopp-Schneider, A.6
Riester, D.7
Schwab, M.8
Witt, O.9
-
77
-
-
54049152858
-
A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships
-
Nasveschuk CG, Ungermannova D, Liu X, Phillips AJ. (2008) A concise total synthesis of largazole, solution structure, and some preliminary structure activity relationships. Org Lett 10: 3595-3598.
-
(2008)
Org Lett
, vol.10
, pp. 3595-3598
-
-
Nasveschuk, C.G.1
Ungermannova, D.2
Liu, X.3
Phillips, A.J.4
-
78
-
-
46049100010
-
Total synthesis and molecular target of largazole, a histone deacetylase inhibitor
-
Ying Y, Taori K, Kim H, Hong, Luesch H. (2008) Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. J Am Chem Soc 130: 8455-8459.
-
(2008)
J am Chem Soc
, vol.130
, pp. 8455-8459
-
-
Ying, Y.1
Taori, K.2
Kim, H.3
Hong, L.H.4
-
79
-
-
77949831890
-
Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancer cells
-
Zeng X, Yin B, Hu Z, Liao C, Liu J, Li S, Li Z, Nicklaus MC, Zhou G Jiang S. (2010) Total synthesis and biological evaluation of largazole and derivatives with promising selectivity for cancer cells. Org Lett 12: 1368-1371.
-
(2010)
Org Lett
, vol.12
, pp. 1368-1371
-
-
Zeng, X.1
Yin, B.2
Hu, Z.3
Liao, C.4
Liu, J.5
Li, S.6
Li, Z.7
Nicklaus, M.C.8
Zhou G Jiang, S.9
-
80
-
-
0029795991
-
Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function
-
Taunton J, Collins JL, Schreiber SL. (1996) Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function. J Am Chem Soc 118: 10412-10422.
-
(1996)
J am Chem Soc
, vol.118
, pp. 10412-10422
-
-
Taunton, J.1
Collins, J.L.2
Schreiber, S.L.3
-
81
-
-
0027378351
-
Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase
-
Kijima M, Yoshida M, Susita K, Horinouchi S, Beppu T. (1993) Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. J Biol Chem 30: 22429-22435.
-
(1993)
J Biol Chem
, vol.30
, pp. 22429-22435
-
-
Kijima, M.1
Yoshida, M.2
Susita, K.3
Horinouchi, S.4
Beppu, T.5
-
82
-
-
0001811191
-
Histone deacetylase as a new target for cancer chemotherapy
-
Yoshida M, Furumai R, Nishiyama M, Komatsu Y, Nishino N, Horinouchi S. (2001) Histone deacetylase as a new target for cancer chemotherapy. Cancer Chemother Pharmacol S1: S20-S26.
-
(2001)
Cancer Chemother Pharmacol
-
-
Yoshida, M.1
Furumai, R.2
Nishiyama, M.3
Komatsu, Y.4
Nishino, N.5
Horinouchi, S.6
-
83
-
-
0018114158
-
Trichostatin C, a glucopyranosyl hydroxamate
-
Tsuji N, Kobayashi M. (1978) Trichostatin C, a glucopyranosyl hydroxamate. J Antibiot 31: 939-944.
-
(1978)
J Antibiot
, vol.31
, pp. 939-944
-
-
Tsuji, N.1
Kobayashi, M.2
-
84
-
-
0017284850
-
A new antifungal antibiotic, trichostatin
-
Tsuji N, Kobayashi M, Nagashima K, Wakisaka Y, Koizumi K. (1976) A new antifungal antibiotic, trichostatin. J Antibiot 29: 1-6.
-
(1976)
J Antibiot
, vol.29
, pp. 1-6
-
-
Tsuji, N.1
Kobayashi, M.2
Nagashima, K.3
Wakisaka, Y.4
Koizumi, K.5
-
85
-
-
0021990106
-
Trichostatin C, a new inducer of differentiation of friend leukemic cells
-
Yoshida M, Iwamoto Y, Uozumi T, Beeppu T. (1985) Trichostatin C, a new inducer of differentiation of friend leukemic cells. Agric Biol Chem 49: 563-565.
-
(1985)
Agric Biol Chem
, vol.49
, pp. 563-565
-
-
Yoshida, M.1
Iwamoto, Y.2
Uozumi, T.3
Beeppu, T.4
-
86
-
-
0023195737
-
Effects of trichostatins on differentiation of murine erythroleukemia cells
-
Yoshida M, Nomura S, Beppu T. (1987) Effects of trichostatins on differentiation of murine erythroleukemia cells. Cancer Res 47: 3688-3691.
-
(1987)
Cancer Res
, vol.47
, pp. 3688-3691
-
-
Yoshida, M.1
Nomura, S.2
Beppu, T.3
-
87
-
-
0024996768
-
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
-
Yoshida, M, Kijima M, Akita M, Beppu T. (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265: 17174-17179.
-
(1990)
J Biol Chem
, vol.265
, pp. 17174-17179
-
-
Yoshida, M.1
Kijima, M.2
Akita, M.3
Beppu, T.4
-
88
-
-
0036171675
-
The histone-deacetylase inhibitor trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells
-
Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, Schuppan D. (2002) The histone-deacetylase inhibitor trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol 36: 233-240.
-
(2002)
J Hepatol
, vol.36
, pp. 233-240
-
-
Herold, C.1
Ganslmayer, M.2
Ocker, M.3
Hermann, M.4
Geerts, A.5
Hahn, E.G.6
Schuppan, D.7
-
89
-
-
0035169123
-
Trichostatin A inhibits ß-casein expression in mammary epithelial cells
-
Pujuguet P, Radisky D, Levy D, Lacza C, Bissell MJ. (2001) Trichostatin A inhibits ß-casein expression in mammary epithelial cells. J Cell Biochem 83: 660-670.
-
(2001)
J Cell Biochem
, vol.83
, pp. 660-670
-
-
Pujuguet, P.1
Radisky, D.2
Levy, D.3
Lacza, C.4
Bissell, M.J.5
-
90
-
-
0032989027
-
Antitumor activity in vitro and in vivo of selective differentiating agents containing hydroxamate
-
Qiu L, Kelso MJ, Hansen C, West ML, Fairlie DP, Parsons PG. (1999) Antitumor activity in vitro and in vivo of selective differentiating agents containing hydroxamate. Br J Cancer 80: 1252-1258.
-
(1999)
Br J Cancer
, vol.80
, pp. 1252-1258
-
-
Qiu, L.1
Kelso, M.J.2
Hansen, C.3
West, M.L.4
Fairlie, D.P.5
Parsons, P.G.6
-
92
-
-
0036735385
-
FK228 (Depsipeptide as a natural prodrug that inhibits class I histone deacetylases
-
Furamai R, Matsuyuma A, Kobashi N, Lee KH, Nishiyama N, Nakajima H, Tanka A, Komatsu Y, Nishino N, Yoshida M, Horinouchi S. (2002) FK228 Depsipeptide as a natural prodrug that inhibits class I histone deacetylases. Cancer Res 62: 4916-4921.
-
(2002)
Cancer Res
, vol.62
, pp. 4916-4921
-
-
Furamai, R.1
Matsuyuma, A.2
Kobashi, N.3
Lee, K.H.4
Nishiyama, N.5
Nakajima, H.6
Tanka, A.7
Komatsu, Y.8
Nishino, N.9
Yoshida, M.10
Horinouchi, S.11
-
93
-
-
36148975704
-
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor
-
Yurek-George A, Cecil ARL, Mo AHK, Wen S, Rogers H, Habens F, Maeda S, Yoshida M, Packham G, Ganesan A. (2007) The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor. J Med Chem 50:5720-5726.
-
(2007)
J Med Chem
, vol.50
, pp. 5720-5726
-
-
Yurek-George, A.1
Cecil, A.2
Mo, A.3
Wen, S.4
Rogers, H.5
Habens, F.6
Maeda, S.7
Yoshida, M.8
Packham, G.9
Ganesan, A.10
-
94
-
-
0035180541
-
Spiruchostatins A and B, novel gene expression-enhancing substrances produced by Pseudomonas sp
-
Masuoka Y, Nagai A, Shin-ya K, Furihata K, Nagai K, Suzuki K, Hayakawa Y, Seto Y (2001) Spiruchostatins A and B, novel gene expression-enhancing substrances produced by Pseudomonas sp. Tetrahedron Lett 42: 41-44.
-
(2001)
Tetrahedron Lett
, vol.42
, pp. 41-44
-
-
Masuoka, Y.1
Nagai, A.2
Shin-Ya, K.3
Furihata, K.4
Nagai, K.5
Suzuki, K.6
Hayakawa, Y.7
Seto, Y.8
-
95
-
-
0942265466
-
Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor
-
Yurek-George A, Habens F, Brimmell M, Packham G Ganesan A. (2004) Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor. JAm Chem Soc 126: 1030-1031.
-
(2004)
Jam Chem Soc
, vol.126
, pp. 1030-1031
-
-
Yurek-George, A.1
Habens, F.2
Brimmell, M.3
Packham G Ganesan, A.4
-
96
-
-
70350507928
-
Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5"-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity
-
Narita K, Kikuchi T, Watanabe K, Takizawa T, Oguchi T, Kudo K, Matsuhara K, Abe H, Yamori T, Yoshida M, Katoh T. (2009) Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5"-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity. Chem Eur J15: 11174-11186.
-
(2009)
Chem Eur
, vol.J15
, pp. 11174-11186
-
-
Narita, K.1
Kikuchi, T.2
Watanabe, K.3
Takizawa, T.4
Oguchi, T.5
Kudo, K.6
Matsuhara, K.7
Abe, H.8
Yamori, T.9
Yoshida, M.10
Katoh, T.11
-
97
-
-
59349084488
-
Role of HDAC2 in the pathophysiology of COPD
-
Barnes PJ. (2009) Role of HDAC2 in the pathophysiology of COPD. Annu Rev Physiol 71: 451-464.
-
(2009)
Annu Rev Physiol
, vol.71
, pp. 451-464
-
-
Barnes, P.J.1
-
98
-
-
21044458874
-
Decreased histone deacetylase activity in chronic obstructive pulmonary disease
-
Ito K, Ito M, Elliott MW, Cosio B, Carmaori G, Kon OM, Barczyk A, Hayashi S, Adcock LM, Hogg JC, Barnes PJ. (2005) Decreased histone deacetylase activity in chronic obstructive pulmonary disease. New Engl JMed 352: 1957-1976.
-
(2005)
New Engl Jmed
, vol.352
, pp. 1957-1976
-
-
Ito, K.1
Ito, M.2
Elliott, M.W.3
Cosio, B.4
Carmaori, G.5
Kon, O.M.6
Barczyk, A.7
Hayashi, S.8
Adcock, L.M.9
Hogg, J.C.10
Barnes, P.J.11
-
99
-
-
28844497060
-
Oxidative stress causes HDAC2 reduction by nitration, ubiquitinylation and proteasomal degradation
-
(Abstr.)
-
Osoata G Adcock IM, Barnes PJ, Ito K. (2005) Oxidative stress causes HDAC2 reduction by nitration, ubiquitinylation and proteasomal degradation. Proc Am Thorac Soc 2: A755 (Abstr.)
-
(2005)
Proc am Thorac Soc
, vol.2
-
-
Osoata G Adcock, I.M.1
Barnes, P.J.2
Ito, K.3
-
100
-
-
57349158300
-
Oxidative stress-induced PI3-kinase activation reduces HDAC activity and is inhibited by theophylline
-
:, (Abstr.)
-
Failla M, To Y, Ito M, Adcock IM, Barnes PJ, Ito K. (2007) Oxidative stress-induced PI3-kinase activation reduces HDAC activity and is inhibited by theophylline. Proc Am Thorac Soc 2: A45 (Abstr.)
-
(2007)
Proc am Thorac Soc
, vol.2
-
-
Failla, M.1
To, Y.2
Ito, M.3
Adcock, I.M.4
Barnes, P.J.5
Ito, K.6
-
101
-
-
84973118454
-
Activation of histone deaetylases 1 (Hdac1) protects against dna damage and increases neuronal survival. Wolf Greenfield & Sacks PC, Boston MA, US Applicaton #20100075926
-
Tsai LH, Haggarty SJ, Kim D (2010) Activation of histone deaetylases 1 (hdac1) protects against dna damage and increases neuronal survival. Wolf Greenfield & Sacks PC, Boston MA, US Applicaton #20100075926, USPTO Class 514 82.
-
(2010)
USPTO Class
, vol.514
, pp. 82
-
-
Tsai, L.H.1
Haggarty, S.J.2
Kim, D.3
-
102
-
-
33750541268
-
Down-regulation of androgen receptor by 3,3,-diindolylmethane contributes to inhibition of cell proliferation and induction of apooptosis in both hormone-sensitive LNCaP and insensitive C4-2B Prosate Cancer Cells
-
Bhuiyan MMR, Li Y, Banerjee S, Ahmed F, Wang Z, Ali S, Sarkar FH. (2006) Down-regulation of androgen receptor by 3,3-diindolylmethane contributes to inhibition of cell proliferation and induction of apooptosis in both hormone-sensitive LNCaP and insensitive C4-2B Prosate Cancer Cells. Cancer Res 66: 10064-10072.
-
(2006)
Cancer Res
, vol.66
, pp. 10064-10072
-
-
Bhuiyan, M.1
Li, Y.2
Banerjee, S.3
Ahmed, F.4
Wang, Z.5
Ali, S.6
Sarkar, F.H.7
-
103
-
-
40949131914
-
Mammalian target of rapamycin repression by 3,3,-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-d-over-expressing PC3 cells
-
Kong D, Banerjee S, Huang W, Li Y, Wang Z, Kim HRC, Sarkar FH. (2008) Mammalian target of rapamycin repression by 3,3-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-d-over-expressing PC3 cells. Cancer Res 68: 1927-1934.
-
(2008)
Cancer Res
, vol.68
, pp. 1927-1934
-
-
Kong, D.1
Banerjee, S.2
Huang, W.3
Li, Y.4
Wang, Z.5
Kim, H.6
Sarkar, F.H.7
-
104
-
-
76549093815
-
Chemopreventive agent 3,3,-diinolylmethane selectively induces proteasomal degradation of class I histone deacetylases
-
Li Y, Li X, Guo B. (2010) Chemopreventive agent 3,3-diinolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Cancer Res 70: 646-654.
-
(2010)
Cancer Res
, vol.70
, pp. 646-654
-
-
Li, Y.1
Li, X.2
Guo, B.3
|