Abrus Agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death

Molecular Carcinogenesis

Volumn 56, Issue 2, 2017, Pages 389-401

  Panda, Prashanta Kumar ^a   Behera, Birendra ^b   Meher, Biswa Ranjan ^c   Das, Durgesh Nandini ^a   Mukhopadhyay, Subhadip ^a   Sinha, Niharika ^a   Naik, Prajna Paramita ^a   Roy, Bibhas ^b   Das, Joyjyoti ^b   Paul, Subhankar ^a   Maiti, Tapas K ^b   Agarwal, Rajesh ^d,e   Bhutia, Sujit K ^a  

^a NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY   (India)

^c INDIAN INSTITUTE OF SCIENCE   (India)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Abrus agglutinin; Akt; apoptosis; autophagic cell death; ER stress; PH domain

Indexed keywords

3 METHYLADENINE; ABRUS AGGLUTININ; ACETYLCYSTEINE; ACRIDINE ORANGE; AGGLUTININ; AUTOPHAGY RELATED PROTEIN 5; BECLIN 1; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; ENZYME INHIBITOR; FLUOROURACIL; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAX; PROTEIN KINASE; PROTEIN KINASE R; SALUBRINAL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; EIF2AK3 PROTEIN, HUMAN; PLANT LECTIN; PROTEIN KINASE B; RIBOSOME INACTIVATING PROTEIN 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER RESISTANCE; CASKI CELL LINE; CELL DEATH; CELL KILLING; CELL VIABILITY; CERVICAL CANCER CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE OVEREXPRESSION; GENE SILENCING; HACAT CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PLECKSTRIN HOMOLOGY DOMAIN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIHA CELL LINE; ABRUS; CHEMISTRY; DRUG EFFECTS; FEMALE; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR MODEL; PATHOLOGY; UTERINE CERVICAL NEOPLASMS;

ABRUS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; FEMALE; HELA CELLS; HUMANS; MODELS, MOLECULAR; PLANT LECTINS; PLECKSTRIN HOMOLOGY DOMAINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOME INACTIVATING PROTEINS, TYPE 2; UTERINE CERVICAL NEOPLASMS;

EID: 84971571566     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22502     Document Type: Article

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