Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Li, Chunyang ^a   Chen, Jie ^b   Lu, Bangmin ^a   Shi, Zheng ^a   Wang, Hailian ^a,b   Zhang, Bin ^a   Zhao, Kailiang ^a   Qi, Wei ^a   Bao, Jinku ^a   Wang, Yi ^b,c  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CASPASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT LECTIN; POLYGONATUM ODORATUM LECTIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; HERBACEOUS AGENT; LECTIN; MANNOSE; TARGET OF RAPAMYCIN KINASE;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRUCTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME REGULATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG CANCER CELL LINE; LUNG FIBROBLAST; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MODEL; MTT ASSAY; OXIDATIVE STRESS; POLYGONATUM; POLYGONATUM ODORATUM; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CELL LINE; CHEMISTRY; DRUG EFFECTS; HELA CELL LINE; LUNG TUMOR; METABOLISM; NON SMALL CELL LUNG CANCER; PATHOLOGY; PROTEIN MOTIF;

AMINO ACID MOTIFS; APOPTOSIS; AUTOPHAGY; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE; DRUGS, CHINESE HERBAL; HELA CELLS; HUMANS; LECTINS; LUNG NEOPLASMS; MANNOSE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; POLYGONATUM; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84903773018     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101526     Document Type: Article

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