Abrus agglutinin suppresses human hepatocellular carcinoma in vitro and in vivo by inducing caspase-mediated cell death

Acta Pharmacologica Sinica

Volumn 35, Issue 6, 2014, Pages 814-824

  Mukhopadhyay, Subhadip ^a   Panda, Prashanta Kumar ^a   Das, Durgesh Nandini ^a   Sinha, Niharika ^a   Behera, Birendra ^b   Maiti, Tapas Kumar ^b   Bhutia, Sujit Kumar ^a  

^a NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Abrus agglutinin; Akt; Anticancer drug; apoptosis; caspase; hepatocellular carcinoma; HepG2 xenografts; Hsp90 NF B

Indexed keywords

ABRUS AGGLUTININ; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; HEAT SHOCK PROTEIN 90; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PLANT EXTRACT; PROTEIN KINASE B; UNCLASSIFIED DRUG; CASPASE; PLANT LECTIN;

ABRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; COMPARATIVE STUDY; DNA FRAGMENTATION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR XENOGRAFT; WESTERN BLOTTING; ANIMAL; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG EFFECTS; LIVER; LIVER NEOPLASMS; MALE; METABOLISM; NUDE MOUSE; PATHOLOGY;

ABRUS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL DEATH; HEP G2 CELLS; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MICE, NUDE; PLANT LECTINS;

EID: 84902260115     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.15     Document Type: Article

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