Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO 2 sensing and signaling

Journal of Biological Chemistry

Volumn 287, Issue 17, 2012, Pages 14004-14011

  Oliver, Kathryn M ^a   Lenihan, Colin R ^a   Bruning, Ulrike ^a   Cheong, Alex ^a   Laffey, John G ^b   McLoughlin, Paul ^a   Taylor, Cormac T ^a   Cummins, Eoin P ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE RESPIRATORY DISTRESS SYNDROME; BENEFICIAL EFFECTS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CLINICAL CONDITIONS; ELEVATED CO; EPITHELIAL CELLS; GLYCOGEN SYNTHASE KINASE-3; HYPERCAPNIA; HYPOVENTILATION; IN-VIVO; INFLAMMATORY DISEASE; INTRACELLULAR SIGNALING MOLECULES; LUNG INJURY; MECHANICAL DAMAGES; MOLECULAR MECHANISM; MOUSE EMBRYONIC FIBROBLASTS; NUCLEAR LOCALIZATION; RELATIVE CONTRIBUTION; TRANSCRIPTIONAL RESPONSE;

BIOLOGICAL ORGANS; CELL CULTURE; PULMONARY DISEASES;

CARBON DIOXIDE;

CARBON DIOXIDE; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEINASE; TRANSCRIPTION FACTOR RELB; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; HYPERCAPNIA; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG INJURY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RAT; RESPIRATORY ACIDOSIS; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CARBON DIOXIDE; CELL LINE, TUMOR; CELL NUCLEUS; EPITHELIAL CELLS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; HYPERCAPNIA; MICE; MODELS, BIOLOGICAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELB;

EID: 84859954506     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.347971     Document Type: Article

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