Platelets contribute to amyloid-b aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release

Science Signaling

Volumn 9, Issue 429, 2016, Pages

  Donner, Lili ^a   Fälker, Knut ^b   Gremer, Lothar ^a,c   Klinker, Stefan ^a   Pagani, Giulia ^a   Ljungberg, Liza U ^b   Lothmann, Kimberley ^a   Rizz, Federica ^d,e   Schaller, Martin ^f   Gohlke, Holger ^a   Willbold, Dieter ^a,c   Grenegard, Magnus ^b   Elvers, Margitta ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b ÖREBRO UNIVERSITY   (Sweden)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d UNIVERSITY OF PARMA   (Italy)

^e NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^f UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ALPHA2 INTEGRIN; AMYLOID BETA PROTEIN; CLOPIDOGREL; CLUSTERIN; FIBRINOGEN; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; CLU PROTEIN, HUMAN; CLU PROTEIN, MOUSE; FIBRINOGEN RECEPTOR; INTEGRIN; ITGA2B PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD VESSEL; EXTRACELLULAR MATRIX; FEMALE; GLANZMANN DISEASE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN SECRETION; SIGNAL TRANSDUCTION; THROMBOCYTE ADHESION; VASCULAR AMYLOIDOSIS; ADOLESCENT; ADULT; ALZHEIMER DISEASE; ANIMAL; BRAIN; BRAIN CIRCULATION; C57BL MOUSE; CROSS BREEDING; CYTOLOGY; DISEASE EXACERBATION; GENOTYPE; METABOLISM; MIDDLE AGED; MOLECULAR DYNAMICS; PHOSPHORYLATION; THROMBOCYTE; TRANSGENIC MOUSE; YOUNG ADULT;

ADOLESCENT; ADULT; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BLOOD PLATELETS; BRAIN; CEREBROVASCULAR CIRCULATION; CLUSTERIN; CROSSES, GENETIC; DISEASE PROGRESSION; FEMALE; FIBRINOGEN; GENOTYPE; HUMANS; INTEGRIN ALPHA2; INTEGRINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; MOLECULAR DYNAMICS SIMULATION; PHOSPHORYLATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84971265417     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aaf6240     Document Type: Article

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