-
1
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256(5054):184-185
-
(1992)
Science
, vol.256
, Issue.5054
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
2
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353-356
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
3
-
-
0019955625
-
The relationship between senile plaques and cerebral blood vessels in Alzheimer's disease and senile dementia. Morphological mechanism of senile plaque production
-
Miyakawa T, Shimoji A, Kuramoto R, Higuchi Y (1982) The relationship between senile plaques and cerebral blood vessels in Alzheimer's disease and senile dementia. Morphological mechanism of senile plaque production. Virchows Arch B Cell Pathol Incl Mol Pathol 40:121-129
-
(1982)
Virchows Arch B Cell Pathol Incl Mol Pathol
, vol.40
, pp. 121-129
-
-
Miyakawa, T.1
Shimoji, A.2
Kuramoto, R.3
Higuchi, Y.4
-
4
-
-
0022921664
-
An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease
-
Hardy JA, Mann DMA, Wester P, Winblad B (1986) An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiol Aging 7:489-502
-
(1986)
Neurobiol Aging
, vol.7
, pp. 489-502
-
-
Hardy, J.A.1
Mann, D.M.A.2
Wester, P.3
Winblad, B.4
-
5
-
-
13244267220
-
Familial Alzheimer's disease
-
Levy E, Frangione B (1991) Familial Alzheimer's disease. Curr Biol 1(5):312-314
-
(1991)
Curr Biol
, vol.1
, Issue.5
, pp. 312-314
-
-
Levy, E.1
Frangione, B.2
-
6
-
-
0026879650
-
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene
-
Hendriks L, van Duijn CM, Cras P, Cruts M, Van Hul W, van Harskamp F, Warren A, McInnis MG, Antonarakis SE, Martin JJ et al. (1992) Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet 1(3):218-221
-
(1992)
Nat Genet
, vol.1
, Issue.3
, pp. 218-221
-
-
Hendriks, L.1
van Duijn, C.M.2
Cras, P.3
Cruts, M.4
Van Hul, W.5
van Harskamp, F.6
Warren, A.7
McInnis, M.G.8
Antonarakis, S.E.9
Martin, J.J.10
-
7
-
-
29444442794
-
-
Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38(1):24-26
-
Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38(1):24-26
-
-
-
-
8
-
-
25144503548
-
Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls
-
Kumar-Singh S, Pirici D, McGowan E, Serneels S, Ceuterick C, Hardy J, Duff K, Dickson D, Van Broeckhoven C (2005) Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. Am J Pathol 167(2):527-543
-
(2005)
Am J Pathol
, vol.167
, Issue.2
, pp. 527-543
-
-
Kumar-Singh, S.1
Pirici, D.2
McGowan, E.3
Serneels, S.4
Ceuterick, C.5
Hardy, J.6
Duff, K.7
Dickson, D.8
Van Broeckhoven, C.9
-
9
-
-
17644397044
-
Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice
-
Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA (2005) Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochem Res 30(2):201-205
-
(2005)
Neurochem Res
, vol.30
, Issue.2
, pp. 201-205
-
-
Falangola, M.F.1
Lee, S.P.2
Nixon, R.A.3
Duff, K.4
Helpern, J.A.5
-
10
-
-
33750000602
-
Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages
-
in press
-
Cullen KE, Kocsi Z, Stone J. Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages. Neurobiol Aging (in press)
-
Neurobiol Aging
-
-
Cullen, K.E.1
Kocsi, Z.2
Stone, J.3
-
11
-
-
0025371509
-
-
Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD (1990) Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein. Science 248(4956):745-748
-
Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD (1990) Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein. Science 248(4956):745-748
-
-
-
-
12
-
-
0005775566
-
Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells
-
Goldgaber D, Harris HW, Hla T, Maciag T, Donnelly RJ, Jacobsen JS, Vitek MP, Gajdusek DC (1989) Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci USA 86(19):7606-7610
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, Issue.19
, pp. 7606-7610
-
-
Goldgaber, D.1
Harris, H.W.2
Hla, T.3
Maciag, T.4
Donnelly, R.J.5
Jacobsen, J.S.6
Vitek, M.P.7
Gajdusek, D.C.8
-
13
-
-
0036703483
-
Reversible memory loss in a mouse transgenic model of Alzheimer's disease
-
Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH (2002) Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 22(15):6331-6335
-
(2002)
J Neurosci
, vol.22
, Issue.15
, pp. 6331-6335
-
-
Kotilinek, L.A.1
Bacskai, B.2
Westerman, M.3
Kawarabayashi, T.4
Younkin, L.5
Hyman, B.T.6
Younkin, S.7
Ashe, K.H.8
-
14
-
-
23044468691
-
The synaptic Abeta hypothesis of Alzheimer disease
-
Tanzi RE (2005) The synaptic Abeta hypothesis of Alzheimer disease. Nat Neurosci 8(8):977-979
-
(2005)
Nat Neurosci
, vol.8
, Issue.8
, pp. 977-979
-
-
Tanzi, R.E.1
-
15
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2(8):864-870
-
(1996)
Nat Med
, vol.2
, Issue.8
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
16
-
-
30344465740
-
Regulation of CRE-dependent transcription by presenilins: Prospects for therapy of Alzheimer's disease
-
Beglopoulos V, Shen J (2006) Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease. Trends Pharmacol Sci 27(1):33-40
-
(2006)
Trends Pharmacol Sci
, vol.27
, Issue.1
, pp. 33-40
-
-
Beglopoulos, V.1
Shen, J.2
-
17
-
-
0037197836
-
Tau is essential to β-amyloid-induced neurotoxicity
-
Rapoport M, Dawson H, Binder LI., Vitek MP, Ferreira A (2002) Tau is essential to β-amyloid-induced neurotoxicity. Proc Natl Acad Sci (USA) 99:6364-6369
-
(2002)
Proc Natl Acad Sci (USA)
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
18
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293(5534):1487-1491
-
(2001)
Science
, vol.293
, Issue.5534
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
Jones, G.6
Yen, S.H.7
Sahara, N.8
Skipper, L.9
Yager, D.10
Eckman, C.11
Hardy, J.12
Hutton, M.13
McGowan, E.14
-
19
-
-
0141518676
-
Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply
-
Atwood CS, Bowen RL, Smith MA, Perry G (2003) Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply. Brain Res Brain Res Rev 43(1):164-178
-
(2003)
Brain Res Brain Res Rev
, vol.43
, Issue.1
, pp. 164-178
-
-
Atwood, C.S.1
Bowen, R.L.2
Smith, M.A.3
Perry, G.4
-
20
-
-
0031679480
-
Cerebral amyloid angiopathy: Amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
-
Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE (1998) Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol 153:725-733
-
(1998)
Am J Pathol
, vol.153
, pp. 725-733
-
-
Weller, R.O.1
Massey, A.2
Newman, T.A.3
Hutchings, M.4
Kuo, Y.M.5
Roher, A.E.6
-
21
-
-
0034019944
-
Apolipoprotein E genotype and cerebral amyloid angiopathy-related hemorrhage
-
McCarron MO, Nicoll JA (2000) Apolipoprotein E genotype and cerebral amyloid angiopathy-related hemorrhage. Ann N Y Acad Sci 903:176-179
-
(2000)
Ann N Y Acad Sci
, vol.903
, pp. 176-179
-
-
McCarron, M.O.1
Nicoll, J.A.2
-
22
-
-
0029670094
-
beta-Amyloid-mediated vasoactivity and vascular endothelial damage
-
Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380(6570):168-171
-
(1996)
Nature
, vol.380
, Issue.6570
, pp. 168-171
-
-
Thomas, T.1
Thomas, G.2
McLendon, C.3
Sutton, T.4
Mullan, M.5
-
23
-
-
21844476174
-
Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice
-
Miao J, Vitek MP, Xu F, Previti ML, Davis J, Van Nostrand WE (2005) Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci 25(27):6271-6277
-
(2005)
J Neurosci
, vol.25
, Issue.27
, pp. 6271-6277
-
-
Miao, J.1
Vitek, M.P.2
Xu, F.3
Previti, M.L.4
Davis, J.5
Van Nostrand, W.E.6
-
24
-
-
0037436022
-
Cerebral hemorrhage and amyloid-beta
-
Atwood CS, Perry G, Smith MA (2003) Cerebral hemorrhage and amyloid-beta. Science 299(5609):1014
-
(2003)
Science
, vol.299
, Issue.5609
, pp. 1014
-
-
Atwood, C.S.1
Perry, G.2
Smith, M.A.3
|