Amyloid beta peptide-activated signal pathways in human platelets

European Journal of Pharmacology

Volumn 588, Issue 2-3, 2008, Pages 259-266

  Shen, Ming Y ^a   Hsiao, George ^a   Fong, Tsorng H ^b   Chen, Hui M ^b   Chou, Duen S ^a   Lin, Chien H ^a,b   Sheu, Joen R ^a,b   Hsu, Chung Y ^b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Amyloid ; p38 MAPK; PAR1; PI3 kinase Akt; Platelet

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMYLOID BETA PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARISTOLOCHIC ACID; COLLAGEN; INDOMETACIN; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PROTEIN KINASE B; PROTEINASE ACTIVATED RECEPTOR 1; RAF PROTEIN; RAS PROTEIN; SCH 79797; STRESS ACTIVATED PROTEIN KINASE 1; THROMBIN; THROMBOXANE A2;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMYLOID BETA-PROTEIN; BLOOD PLATELETS; ENZYME ACTIVATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 8; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET AGGREGATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; QUINAZOLINES; RECEPTOR, PAR-1; RECEPTOR, PAR-2; SIGNAL TRANSDUCTION;

EID: 44649190477     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.04.040     Document Type: Article

References (26)

1. Bugaud F., Nadal-Wollbold F., Levy-Toledano S., Rosa J.P., and Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellular-signal regulated kinase in human platelets. Blood 94 (1999) 3800-3805
2. Chen M., Inestrosa N.C., Ross G.S., and Fernandez H.L. Platelets are the primary source of amyloid β-peptide in human blood. Biochem. Biophys. Res. Commun. 213 (1995) 96-103
3. 2 cascade in hydroperoxide-stressed platelets. Free Radic. Biol. Med. 35 (2003) 616-625
4. Franke T.F., Yang S.I., Chan T.O., Datta K., Kazlauskas A., Morrison D.K., Kaplan D.R., and Tsichlis P.N. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81 (1995) 727-736
5. Fryer J.D., Simmons K., Parsadanian M., Bales K.R., Paul S.M., Sullivan P.M., and Holtzman D.M. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J. Neurosci. 25 (2005) 2803-2810
6. Gurol M.E., Irizarry M.C., Smith E.E., Raju S., Diaz-Arrastia R., Bottiglieri T., Rosand J., Growdon J.H., and Greenberg S.M. Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology 66 (2006) 23-29
7. Herczenik E., Bouma B., Korporaal S.J.A., Strangi R., Zeng Q., Gros P., Van Eck M., Van Berkel T.J.C., Gebbink M.F.B.G., and Akkerman J.N. Activation of human platelets by misfolded protein. Arterioscler. Thromb. Vasc. Biol. 27 (2007) 1657-1665
8. Herzig M.C., Winkler D.T., Burgermeister P., Pfeifer M., Kohler E., Schmidt S.D., Danner S., Abramowski D., Sturchler-Pierrat C., Burki K., van Duinen S.G., Maat-Schieman M.L., Staufenbiel M., Mathews P.M., and Jucker M. Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat. Neurosci. 7 (2004) 954-960
9. Hsiao G., Lin K.H., Chang Y., Chen T.L., Tzu N.H., Chou D.S., and Sheu J.R. Protective mechanisms of inosine in platelet activation and cerebral ischemic damage. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 1998-2004
10. Hsiao G., Lee J.J., Lin K.H., Shen C.H., Fong T.H., Chou D.S., and Sheu J.R. Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies. Cardiovasc. Res. 75 (2007) 782-792
11. Hsu M.J., Hsu C.Y., Chen B.C., Chen M.C., Ou G., and Lin C.H. Apoptosis signal-regulating kinase 1 in amyloid beta peptide-induced cerebral endothelial cell apoptosis. J. Neurosci. 27 (2007) 5719-5729
12. Hughes P.E., Renshaw M.W., Pfaff M., Forsyth J., Keivens V.M., Schwartz M.A., and Ginsberg M.H. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88 (1997) 521-530
13. Kahn M.L., Zheng Y.W., Huang W., Bigornia V., Zeng D., Moff S., Farese Jr. R.V., Tam C., and Coughlin S.R. A dual thrombin receptor system for platelet activation. Nature 394 (1998) 690-694
14. Li Q.X., Berndt M.C., Bush A.I., Rumble B., Mackenzie I., Friedhuber A., Beyreuther K., and Masters C.L. Membrane-associated forms of the beta A4 amyloid protein precursor of Alzheimer's disease in human platelets and brain: surface expression on the activated human platelet. Blood 84 (1994) 133-142
15. Mackic J.B., Bading J., Ghiso J., Walker L., Wisniewski T., Frangione B., and Zlokovic B.V. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul. Pharmacol. 38 (2002) 303-313
16. McCormick F., and Wittinghofer A. Interactions between Ras proteins and their effectors. Curr. Opin. Biotechnol. 7 (1996) 449-456
17. Rosado J.A., and Sage S.O. The ERK cascade, a new pathway involved in the activation of store-mediated calcium entry in human platelets. Trends Cardiovasc. Med. 12 (2002) 229-234
18. Saklatvala J., Rawlinson L., Waller R.J., Sarsfield S., Lee J.C., Morton L.F., Barnes M.J., and Farndale R.W. Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J. Biol. Chem. 271 (1996) 6586-6589
19. Sheu J.R., Hung W.C., Wu C.H., Ma M.C., Kan Y.C., Lin C.H., Lin M.S., Luk H.N., and Yen M.H. Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia. Circulation 99 (1999) 3056-3062
20. Skovronsky D.M., Lee V.M., and Pratico D. Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase. C. J. Biol. Chem. 276 (2001) 17036-17043
21. Smith C.C. Stimulated release of the β-amyloid protein of Alzheimer's disease by normal human platelets. Neurosci. Lett. 235 (1997) 157-159
22. Tedgui A., and Mallat Z. Platelets in atherosclerosis: a new role for beta-amyloid peptide beyond Alzheimer's disease. Circ. Res. 90 (2002) 1145-1146
23. van Dijk E.J., Prins N.D., Vermeer S.E., Hofman A., van Duijn C.M., Koudstaal P.J., and Breteler M.M. Plasma amyloid beta, apolipoprotein E, lacunar infarcts, and white matter lesions. Ann. Neurol. 55 (2004) 570-575
24. Wisniewski T., Ghiso J., and Frangione B. Biology of β-amyloid in Alzheimer's disease. Neurobiol. Dis. 4 (1997) 313-328
25. Zhang X., Shan P., Alam J., Fu X.Y., and Lee P.J. Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 Kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. J. Biol. Chem. 280 (2005) 8714-8721
26. Zhang-Nunes S.X., Maat-Schieman M.L., van Duinen S.G., Roos R.A., Frosch M.P., and Greenberg S.M. The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol. 16 (2006) 30-39