The error-prone DNA polymerase k promotes temozolomide resistance in glioblastoma through Rad17-dependent activation of ATR-Chk1 signaling

Cancer Research

Volumn 76, Issue 8, 2016, Pages 2340-2353

  Peng, Chenghao ^a   Chen, Zhengxin ^a   Wang, Shuai ^a   Wang, Hong Wei ^b   Qiu, Wenjin ^a   Zhao, Lin ^a   Xu, Ran ^a   Luo, Hui ^a   Chen, Yuanyuan ^c   Chen, Dan ^d   You, Yongping ^a,e   Liu, Ning ^a,e   Wang, Huibo ^a,e  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^e Chinese Glioma Cooperative Group (CGCG)   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; CELL PROTEIN; CHECKPOINT KINASE 1; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE KAPPA; PLACEBO; PROTEASOME; RAD17 PROTEIN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; ALKYLATING AGENT; ATM PROTEIN; ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; DACARBAZINE; POLK PROTEIN, HUMAN; RAD17 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER RESISTANCE; CANCER TISSUE; CELL CYCLE PROGRESSION; CHEMOSENSITIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DNA STRAND BREAKAGE; DNA SYNTHESIS; DRUG CYTOTOXICITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFECT; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME INACTIVATION; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; MULTIPLE CYCLE TREATMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECOMBINATION REPAIR; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UBIQUITINATION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN TUMOR; CELL CYCLE; DRUG RESISTANCE; METABOLISM; PATHOLOGY; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BRAIN NEOPLASMS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DACARBAZINE; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, NEOPLASM; GLIOBLASTOMA; HETEROGRAFTS; HUMANS; MICE; SIGNAL TRANSDUCTION;

EID: 84970960154     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-1884     Document Type: Article

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