Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress

Apoptosis

Volumn 17, Issue 1, 2012, Pages 102-112

  Furusawa, Yukihiro ^a   Iizumi, Takashi ^a   Fujiwara, Yoshisada ^a   Zhao, Qing Li ^a   Tabuchi, Yoshiaki ^a   Nomura, Takaharu ^b   Kondo, Takashi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b CENTRAL RESEARCH INSTITUTE OF ELECTRIC POWER INDUSTRY   (Japan)

Author keywords

ATR; Cell cycle; Chk1; DNA damage response; Heat stress; Hyperthermia

Indexed keywords

CHECKPOINT KINASE 1; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; ENZYME INHIBITION; FLOW CYTOMETRY; HEAT STRESS; HUMAN; HUMAN CELL; HYPERTHERMIA; PRIORITY JOURNAL;

APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; FEVER; G2 PHASE CELL CYCLE CHECKPOINTS; HEAT-SHOCK RESPONSE; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES;

ATAXIA TELANGIECTASIA;

EID: 84856699641     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0660-7     Document Type: Article

References (38)

1. Richter K, Haslbeck M, Buchner J (2010) The heat shock response: life on the verge of death. Mol Cell 40:253-266
2. Iliakis G, Krieg T, Guan J, Wang Y, Leeper D (2004) Evidence for an S-phase checkpoint regulating DNA replication after heat shock: a review. Int J Hyperthermia 20:240-249 (Pubitemid 38425521)
3. Dynlacht JR, Xu M, Pandita RK, Wetzel EA, Roti Roti JL (2004) Effects of heat shock on the Mre11/Rad50/Nbs1 complex inirradiated or unirradiated cells. Int J Hyperthermia 20:144-156 (Pubitemid 38425512)
4. Seno JD, Dynlacht JR (2004) Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. J Cell Physiol 199:157-170 (Pubitemid 38436741)
5. Takahashi A, Ohnishi T (2005) Does gammaH2AX foci formation depend on the presence of DNA double strand breaks? Cancer Lett 229:171-179 (Pubitemid 41429356)
6. Takahashi A, Matsumoto H, Nagayama K, Kitano M, Hirose S, Tanaka H et al (2004) Evidence for the involvement of doublestrand breaks in heat-induced cell killing. Cancer Res 64:8839-8845 (Pubitemid 39665487)
7. Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T et al (2007) Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res 67: 3010-3017 (Pubitemid 46724837)
8. Laszlo A, Fleischer I (2009) The heat-induced gamma-H2AX response does not play a role in hyperthermic cell killing. Int J Hyperthermia 25:199-209
9. Kastan MB, Bartek J (2004) Cell-cycle checkpoint and cancer. Nature 432:316-323
10. Shiloh Y (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3:155-168 (Pubitemid 37328868)
11. Jackson SP, Bartek J (2009) The DNA-damage response in human biology and disease. Nature 461:1071-1078
12. Gerashchenko BI, Gooding G, Dynlacht JR (2010) Hyperthermia alters the interaction of proteins of the Mre11 complex in irradiated cells. Cytometry A 77:940-952
13. Cann KL, Hicks GG (2007) Regulation of the cellular DNA double-strand break response. Biochem Cell Biol 85:663-674 (Pubitemid 351198414)
14. Kumar S, Dodson GE, Trinh A, Puchalski JR, Tibbetts RS (2005) ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells. Cell Cycle 4:1667-1674
15. Ciccia A, Elledge SJ (2010) The DNA damage response: making it safe to play with knives. Mol Cell 40:179-204
16. Nueda A, Hudson F, Mivechi NF, Dynan WS (1999) DNAdependent protein kinase protects against heat-induced apoptosis. J Biol Chem 274:14988-14996
17. Miyakoda M, Suzuki K, Kodama S, Watanabe M (2002) Activation of ATM and phosphorylation of p53 by heat shock. Oncogene 21:1090-1096 (Pubitemid 34174521)
18. Mitchel RE, Chan A, Smith BP, Child SD, Paterson MC (1984) The effects of hyperthermia and ionizing radiation in normal and ataxia telangiectasia human fibroblast lines. Radiat Res 99:627-635 (Pubitemid 14031876)
19. Raaphorst GP, Azzam EI (1982) The thermal sensitivity of normal and ataxia telangiectasia human fibroblasts. Int J Radiat Oncol Biol Phys 8:1947-1950 (Pubitemid 13167380)
20. Nishida H, Tatewaki N, Nakajima Y, Magara T, Ko KM, Hamamori Y et al (2009) Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response. Nucleic Acids Res 37:5678-5689
21. Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NMB, Orr AI et al (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res 64:9152-9159 (Pubitemid 39665530)
22. Jackson JR, Gilmartin A, Imburgia C, Winkler JD, Marshall LA, Roshak A (2000) An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res 60:566-572 (Pubitemid 30094552)
23. Arienti KL, Brunmark A, Axe FU, McClure K, Lee A, Blevitt J et al (2005) Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J Med Chem 48:1873-1885 (Pubitemid 40396318)
24. Yu DY, Zhao QL, Wei ZL, Nomura T, Kashiwakura I, Kagiya TV et al (2009) Enhancement of radiation-induced apoptosis of human lymphoma U937 cells by sanazole. Apoptosis 14:655-664
25. Yu DY, Zhao QL, Wei ZL, Shehata M, Kondo T (2009) Enhancement of hyperthermia-induced apoptosis by sanazole in human lymphoma U937 cells. Int J Hyperthermia 25:364-373
26. Zhao QL, Fujiwara Y, Kondo T (2010) Synergistic induction of apoptosis and caspase-independent autophagic cell death by a combination of nitroxide Tempo and heat shock in human leukemia U937 cells. Apoptosis 15:1270-1283
27. Zhao Q-L, Fujiwara Y, Kondo T (2006) Mechanism of cell death induction by nitroxide and hyperthermia. Free Radic Biol Med 40:1131-1143
28. Furusawa Y, Tabuchi Y, Takahashi A, Wada S, Ohtsuka K, Kondo T (2009) Gene networks involved in apoptosis induced by hyperthermia in human lymphoma U937 cells. Cell Biol Int 33:1253-1262
29. Salunga TL, Tabuchi Y, Takasaki I, Feril LB Jr, Zhao QL, Ohtsuka K et al (2007) Identification of genes responsive to paeoniflorin, a heat shock protein-inducing compound, in human leukemia U937 cells. Int J Hyperthermia 23:529-537 (Pubitemid 350011522)
30. Takahashi A, Mori E, Ohnishi T (2010) The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment. J Radiat Res (Tokyo) 51:91-95
31. Ide H, Nakagawa T, Yasuda M, Kamiyama Y, Muto S, Horie S (2008) DNA damage response in prostate cancer cells after highintensityfocused ultrasound (HIFU) treatment. Anticancer Res 28:639-642
32. Brown EJ, Baltimore D (2000) ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev 14:397-402 (Pubitemid 30131885)
33. de Klein A, Muijtjens M, van Os R, Verhoeven Y, Smit B, Carr AM (2000) Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol 10:479-482 (Pubitemid 30247338)
34. Eguchi A, Meade BR, Chang YC, Fredrickson CT, Willert K, Puri N et al (2009) Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat Biotechnol 27:567-571
35. Kang Y, Cheong HM, Lee JH, Song PI, Lee KH, Kim SY et al (2010) Protein phosphatase 5 is necessary for ATR-mediated DNA repair. Biochem Biophys Res Commun 404:476-481
36. Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J et al (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 8:37-45 (Pubitemid 43064795)
37. Tomita M (2010) Involvement of DNA-PK and ATM in radiation- and heat-induced DNA damage recognition and apoptotic cell death. J Radiat Res (Tokyo) 51:493-501
38. Kim SM, Kumagai A, Lee J, Dunphy WG (2005) Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. J Biol Chem 280:38355-38364 (Pubitemid 43853732)