Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks

DNA Repair

Volumn 12, Issue 5, 2013, Pages 377-388

  Zhang, Xiuli ^a   Lv, Lingna ^a   Chen, Qian ^b   Yuan, Fenghua ^c   Zhang, Ting ^a   Yang, Yeran ^a   Zhang, Hui ^a   Wang, Yun ^b   Jia, Yan ^a   Qian, Liangyue ^c   Chen, Benjamin ^d   Zhang, Yanbin ^c   Friedberg, Errol C ^d   Tang, Tie Shan ^b   Guo, Caixia ^a  

^a Chinese Academy of Sciences and China National Center for Bioinformation   (China)

^b INSTITUTE OF ZOOLOGY   (China)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Laser micro irradiation; MSH2; PCNA; Polymerase kappa; Strand break repair

Indexed keywords

DNA POLYMERASE; DNA POLYMERASE KAPPA; HISTONE H2AX; HYDROGEN PEROXIDE; PROTEIN MSH2; RAD18 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG; XRCC1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; EMBRYO; FEMALE; FIBROBLAST; GENOMIC INSTABILITY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SINGLE STRANDED DNA BREAK; ZINC FINGER MOTIF;

ANIMALS; CELL LINE; DNA BREAKS, DOUBLE-STRANDED; DNA BREAKS, SINGLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; EMBRYONIC STEM CELLS; HYDROGEN PEROXIDE; LASERS; MICE; MICE, KNOCKOUT; MUTS HOMOLOG 2 PROTEIN; NUCLEAR LOCALIZATION SIGNALS; OXIDATIVE STRESS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN STRUCTURE, TERTIARY;

EID: 84876724610     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.02.008     Document Type: Article

References (35)

1. Friedberg E.C. Suffering in silence: the tolerance of DNA damage. Nat. Rev. Mol. Cell Biol. 2005, 6:943-953.
2. Yang W., Woodgate R. What a difference a decade makes: insights into translesion DNA synthesis. Proc. Natl. Acad. Sci. USA 2007, 104:15591-15598.
3. Guo C., Kosarek-Stancel J.N., Tang T.S., Friedberg E.C. Y-family DNA polymerases in mammalian cells. Cell. Mol. Life Sci. 2009, 66:2363-2381.
4. Lehmann A.R., Niimi A., Ogi T., Brown S., Sabbioneda S., Wing J.F., Kannouche P.L., Green C.M. Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair (Amst) 2007, 6:891-899.
5. Choi J.Y., Angel K.C., Guengerich F.P. Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa. J. Biol. Chem. 2006, 281:21062-21072.
6. Stancel J.N., McDaniel L.D., Velasco S., Richardson J., Guo C., Friedberg E.C. Polk mutant mice have a spontaneous mutator phenotype. DNA Repair (Amst) 2009, 8:1355-1362.
7. Ogi T., Shinkai Y., Tanaka K., Ohmori H. Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene. Proc. Natl. Acad. Sci. USA 2002, 99:15548-15553.
8. Mizutani A., Okada T., Shibutani S., Sonoda E., Hochegger H., Nishigori C., Miyachi Y., Takeda S., Yamazoe M. Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells. Cancer Res. 2004, 64:3144-3147.
9. Bi X., Slater D.M., Ohmori H., Vaziri C. DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint. J. Biol. Chem. 2005, 280:22343-22355.
10. Lehmann A.R. New functions for Y family polymerases. Mol. Cell 2006, 24:493-495.
11. Seki M., Gearhart P.J., Wood R.D. DNA polymerases and somatic hypermutation of immunoglobulin genes. EMBO Rep. 2005, 6:1143-1148.
12. McIlwraith M.J., Vaisman A., Liu Y., Fanning E., Woodgate R., West S.C. Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol. Cell 2005, 20:783-792.
13. Petta T.B., Nakajima S., Zlatanou A., Despras E., Couve-Privat S., Ishchenko A., Sarasin A., Yasui A., Kannouche P. Human DNA polymerase iota protects cells against oxidative stress. EMBO J. 2008, 27:2883-2895.
14. Ogi T., Limsirichaikul S., Overmeer R.M., Volker M., Takenaka K., Cloney R., Nakazawa Y., Niimi A., Miki Y., Jaspers N.G., Mullenders L.H., Yamashita S., Fousteri M.I., Lehmann A.R. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol. Cell 2010, 37:714-727.
15. Schenten D., Gerlach V.L., Guo C., Velasco-Miguel S., Hladik C.L., White C.L., Friedberg E.C., Rajewsky K., Esposito G. DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur. J. Immunol. 2002, 32:3152-3160.
16. Hile S.E., Wang X., Lee M.Y., Eckert K.A. Beyond translesion synthesis: polymerase kappa fidelity as a potential determinant of microsatellite stability. Nucleic Acids Res. 2012, 40:1636-1647.
17. Burr K.L., Velasco-Miguel S., Duvvuri V.S., McDaniel L.D., Friedberg E.C., Dubrova Y.E. Elevated mutation rates in the germline of Polkappa mutant male mice. DNA Repair (Amst) 2006, 5:860-862.
18. Zlatanou A., Despras E., Braz-Petta T., Boubakour-Azzouz I., Pouvelle C., Stewart G.S., Nakajima S., Yasui A., Ishchenko A.A., Kannouche P.L. The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol eta in response to oxidative DNA damage in human cells. Mol. Cell 2011, 43:649-662.
19. Guo C., Tang T.S., Bienko M., Dikic I., Friedberg E.C. Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance. J. Biol. Chem. 2008, 283:4658-4664.
20. Cheo D.L., Ruven H.J., Meira L.B., Hammer R.E., Burns D.K., Tappe N.J., van Zeeland A.A., Mullenders L.H., Friedberg E.C. Characterization of defective nucleotide excision repair in XPC mutant mice. Mutat. Res. 1997, 374:1-9.
21. Guo C., Tang T.S., Bienko M., Parker J.L., Bielen A.B., Sonoda E., Takeda S., Ulrich H.D., Dikic I., Friedberg E.C. Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol. Cell. Biol. 2006, 26:8892-8900.
22. Uematsu N., Weterings E., Yano K., Morotomi-Yano K., Jakob B., Taucher-Scholz G., Mari P.O., van Gent D.C., Chen B.P., Chen D.J. Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J. Cell Biol. 2007, 177:219-229.
23. Guo C., Sonoda E., Tang T.S., Parker J.L., Bielen A.B., Takeda S., Ulrich H.D., Friedberg E.C. REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol. Cell 2006, 23:265-271.
24. Zou J., Chen Q., Tang S., Jin X., Chen K., Zhang T., Xiao X. Olaquindox-induced genotoxicity and oxidative DNA damage in human hepatoma G2 (HepG2) cells. Mutat. Res. 2009, 676:27-33.
25. Hishiki A., Hashimoto H., Hanafusa T., Kamei K., Ohashi E., Shimizu T., Ohmori H., Sato M. Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen. J. Biol. Chem. 2009, 284:10552-10560.
26. Takenaka K., Ogi T., Okada T., Sonoda E., Guo C., Friedberg E.C., Takeda S. Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage. J. Biol. Chem. 2006, 281:2000-2004.
27. Fortini P., Pascucci B., Belisario F., Dogliotti E. DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methanesulfonate but not by hydrogen peroxide. Nucleic Acids Res. 2000, 28:3040-3046.
28. Kryston T.B., Georgiev A.B., Pissis P., Georgakilas A.G. Role of oxidative stress and DNA damage in human carcinogenesis. Mutat. Res. 2011, 711:193-201.
29. Velasco-Miguel S., Richardson J.A., Gerlach V.L., Lai W.C., Gao T., Russell L.D., Hladik C.L., White C.L., Friedberg E.C. Constitutive and regulated expression of the mouse Dinb (Polkappa) gene encoding DNA polymerase kappa. DNA Repair (Amst) 2003, 2:91-106.
30. Olsen A.K., Bjortuft H., Wiger R., Holme J., Seeberg E., Bjoras M., Brunborg G. Highly efficient base excision repair (BER) in human and rat male germ cells. Nucleic Acids Res. 2001, 29:1781-1790.
31. Bienko M., Green C.M., Sabbioneda S., Crosetto N., Matic I., Hibbert R.G., Begovic T., Niimi A., Mann M., Lehmann A.R., Dikic I. Regulation of translesion synthesis DNA polymerase eta by monoubiquitination. Mol. Cell 2010, 37:396-407.
32. Williams H.L., Gottesman M.E., Gautier J. Replication-independent repair of DNA interstrand crosslinks. Mol. Cell 2012, 47:140-147.
33. Lan L., Nakajima S., Oohata Y., Takao M., Okano S., Masutani M., Wilson S.H., Yasui A. In situ analysis of repair processes for oxidative DNA damage in mammalian cells. Proc. Natl. Acad. Sci. USA 2004, 101:13738-13743.
34. Nakajima S., Lan L., Kanno S., Usami N., Kobayashi K., Mori M., Shiomi T., Yasui A. Replication-dependent and -independent responses of RAD18 to DNA damage in human cells. J. Biol. Chem. 2006, 281:34687-34695.
35. Kim J.S., Krasieva T.B., Kurumizaka H., Chen D.J., Taylor A.M., Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 2005, 170:341-347.