Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action

Journal of Cell Science

Volumn 129, Issue 10, 2016, Pages 2085-2095

  Xu, Yingke ^a,b   Nan, Di ^a   Fan, Jiannan ^a   Bogan, Jonathan S ^b   Toomre, Derek ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Exocytosis; Glucose transporter; Insulin signaling; Optogenetics; TIRFM

Indexed keywords

CRYPTOCHROME 2; GLUCOSE TRANSPORTER 4; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CIBN; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; AKT3 PROTEIN, MOUSE; GLUCOSE; SLC2A4 PROTEIN, MOUSE;

ADIPOCYTE; AMINO TERMINAL SEQUENCE; ARABIDOPSIS THALIANA; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXOCYTOSIS; HORMONE ACTION; OPTOGENETICS; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANIMAL; CELL MEMBRANE; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MOUSE;

3T3 CELLS; ADIPOCYTES; ANIMALS; CELL MEMBRANE; EXOCYTOSIS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; INSULIN; MICE; OPTOGENETICS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84970948142     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.174805     Document Type: Article

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