A PI3-Kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane

Current Biology

Volumn 12, Issue 21, 2002, Pages 1871-1876

  Tengholm, Anders ^a   Meyer, Tobias ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; INSULIN; MUSCLE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; CELL MEMBRANE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL MEMBRANE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; SIGNAL TRANSDUCTION;

EID: 0037195274     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01223-X     Document Type: Article

References (23)

1. Katso, R., Okkenhaug, K., Ahmadi, K., White, S., Timms, J., and Waterfield, M.D. (2001). Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 17, 615-675.
2. Saltiel, A.R., and Kahn, C.R. (2001). Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806.
3. Bryant, N.J., Govers, R., and James, D.E. (2002). Regulated transport of the glucose transporter GLUT4. Nat. Rev. Mol. Cell Biol. 3, 267-277.
4. Oatey, P.B., Van Weering, D.H., Dobson, S.P., Gould, G.W., and Tavare, J.M. (1997). GLUT4 vesicle dynamics in living 3T3 L1 adipocytes visualized with green-fluorescent protein. Biochem. J. 327, 637-642.
5. Thurmond, D.C., Ceresa, B.P., Okada, S., Elmendorf, J.S., Coker, K., and Pessin, J.E. (1998). Regulation of insulin-stimulated GLUT4 translocation by Munc18c in 3T3L1 adipocytes. J. Biol. Chem. 273, 33876-33883.
6. Patki, V., Buxton, J., Chawla, A., Lifshitz, L., Fogarty, K., Carrington, W., Tuft, R., and Corvera, S. (2001). Insulin action on GLUT4 traffic visualized in single 3T3-L1 adipocytes by using ultra-fast microscopy. Mol. Biol. Cell 12, 129-141.
7. Axelrod, D. (1981). Cell-substrate contacts illuminated by total internal reflection fluorescence J. Cell Biol. 89, 141-145.
8. Steyer, J.A., and Almers, W. (2001). A real-time view of life within 100 nm of the plasma membrane. Nat. Rev. Mol. Cell Biol. 2, 268-275.
9. Gammeltoft, S. (1984). Insulin receptors: Binding kinetics and structure-function relationship of insulin. Physiol. Rev. 64, 1321-1378.
10. Kontos, C.D., Stauffer, T.P., Yang, W.P., York, J.D., Huang, L., Blanar, M.A., Meyer, T., and Peters, K.G. (1998). Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol. Cell. Biol. 18, 4131-4140.
11. Oatey, P.B., Venkateswarlu, K., Williams, A.G., Fletcher, L.M., Foulstone, E.J., Cullen, P.J., and Tavaré, J.M. (1999). Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes. Biochem. J. 344, 511-518.
12. Cheatham, B., Vlahos, C.J., Cheatham, L., Wang, L., Blenis, J., and Kahn, C.R. (1994). Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 14, 4902-4911.
13. Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O., and Ui, M. (1994). Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J. Biol. Chem. 269, 3568-3573.
14. Tanti, J.F., Gremeaux, T., Grillo, S., Calleja, V., Klippel, A., Williams, L.T., Van Obberghen, E., and Le Marchand-Brustel, Y. (1996). Overexpression of a constitutively active form of phosphatidylinositol 3-kinase is sufficient to promote Glut 4 translocation in adipocytes. J. Biol. Chem. 271, 25227-25232.
15. Egawa, K., Sharma, P.M., Nakashima, N., Huang, Y., Huver, E., Boss, G.R., and Olefsky, J.M. (1999). Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J. Biol. Chem. 274, 14306-14314.
16. Isakoff, S.J., Taha, C., Rose, E., Marcusohn, J., Klip, A., and Skolnik, E.Y. (1995). The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake. Proc. Natl. Acad. Sci. USA 92, 10247-10251.
17. Baumann, C.A., Ribon, V., Kanzaki, M., Thurmond, D.C., Mora, S., Shigematsu, S., Bickel, P.E., Pessin, J.E., and Saltiel, A.R. (2000). CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature 407, 202-207.
18. Nave, B.T., Haigh, R.J., Hayward, A.C., Siddle, K., and Shepherd, P.R. (1996). Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes. Biochem. J. 318, 55-60.
19. Clark, S.F., Martin, S., Carozzi, A.J., Hill, M.M., and James, D.E. (1998). Intracellular localization of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: Potential involvement of a membrane skeleton. J. Cell Biol. 140, 1211-1225.
20. Shigematsu, S., Miller, S.L., and Pessin, J.E. (2001). Differentiated 3T3L1 adipocytes are composed of heterogenous cell populations with distinct receptor tyrosine kinase signaling properties. J. Biol. Chem. 276, 15292-15297.
21. Tomiyama, K., Nakata, H., Sasa, H., Arimura, S., Nishio, E., and Watanabe, Y. (1995). Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 212, 263-269.
22. Staiger, H., and Löffler, G. (1998). The role of PDGF-dependent suppression of apoptosis in differentiating 3T3-L1 preadipocytes. Eur. J. Cell Biol. 77, 220-227.
23. Gagnon, A., Dods, P., Roustan-Delatour, N., Chen, C.S., and Sorisky, A. (2001). Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes. Endocrinology 142, 205-212.