-
1
-
-
79953804263
-
Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs
-
Heshe D, Hoogestraat S, Brauckmann C, Karst U, Boos J, Lanvers-Kaminsky C,. Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs. Cancer Chemother Pharmacol 2011; 67: 647-55
-
(2011)
Cancer Chemother Pharmacol
, vol.67
, pp. 647-655
-
-
Heshe, D.1
Hoogestraat, S.2
Brauckmann, C.3
Karst, U.4
Boos, J.5
Lanvers-Kaminsky, C.6
-
2
-
-
77952995998
-
Metabolic modulation of glioblastoma with dichloroacetate
-
Michelakis ED, Sutendra G, Dromparis P, Webster L, Haromy A, Niven E, Maguire C, Gammer TL, Mackey JR, Fulton D, Abdulkarim B, McMurtry MS, et al. Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med; 2010; 2: 31ra4.
-
(2010)
Sci Transl Med
, vol.2
-
-
Michelakis, E.D.1
Sutendra, G.2
Dromparis, P.3
Webster, L.4
Haromy, A.5
Niven, E.6
Maguire, C.7
Gammer, T.L.8
MacKey, J.R.9
Fulton, D.10
Abdulkarim, B.11
McMurtry, M.S.12
-
3
-
-
0031657390
-
Clinical pharmacology and toxicology of dichloroacetate
-
Stacpoole PW, Henderson GN, Yan Z, James MO,. Clinical pharmacology and toxicology of dichloroacetate. Environ Health Perspect 1998; 106 Suppl 4: 989-94. (Pubitemid 28419783)
-
(1998)
Environmental Health Perspectives
, vol.106
, Issue.SUPPL. 4
, pp. 989-994
-
-
Stacpoole, P.W.1
Henderson, G.N.2
Yan, Z.3
James, M.O.4
-
4
-
-
0024452528
-
The pharmacology of dichloroacetate
-
DOI 10.1016/0026-0495(89)90051-6
-
Stacpoole PW,. The pharmacology of dichloroacetate. Metabolism 1989; 38: 1124-44. (Pubitemid 19273807)
-
(1989)
Metabolism: Clinical and Experimental
, vol.38
, Issue.11
, pp. 1124-1144
-
-
Stacpoole, P.W.1
-
5
-
-
53049103850
-
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
-
Michelakis ED, Webster L, Mackey JR,. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 2008; 99: 989-94.
-
(2008)
Br J Cancer
, vol.99
, pp. 989-994
-
-
Michelakis, E.D.1
Webster, L.2
MacKey, J.R.3
-
6
-
-
33846002728
-
+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
-
DOI 10.1016/j.ccr.2006.10.020, PII S1535610806003722
-
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Harry G, Hashimoto K, Porter CJ, et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007; 11: 37-51. (Pubitemid 46054520)
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
Lee, C.T.7
Lopaschuk, G.D.8
Puttagunta, L.9
Bonnet, S.10
Harry, G.11
Hashimoto, K.12
Porter, C.J.13
Andrade, M.A.14
Thebaud, B.15
Michelakis, E.D.16
-
7
-
-
74849137483
-
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
-
Sun RC, Fadia M, Dahlstrom JE, Parish CR, Board PG, Blackburn AC,. Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo. Breast Cancer Res Treat 2010; 120: 253-60.
-
(2010)
Breast Cancer Res Treat
, vol.120
, pp. 253-260
-
-
Sun, R.C.1
Fadia, M.2
Dahlstrom, J.E.3
Parish, C.R.4
Board, P.G.5
Blackburn, A.C.6
-
8
-
-
48749093935
-
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
-
Cao W, Yacoub S, Shiverick KT, Namiki K, Sakai Y, Porvasnik S, Urbanek C, Rosser CJ,. Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation. Prostate 2008; 68: 1223-31.
-
(2008)
Prostate
, vol.68
, pp. 1223-1231
-
-
Cao, W.1
Yacoub, S.2
Shiverick, K.T.3
Namiki, K.4
Sakai, Y.5
Porvasnik, S.6
Urbanek, C.7
Rosser, C.J.8
-
9
-
-
44549083746
-
Dichloroacetate induces apoptosis in endometrial cancer cells
-
Wong JY, Huggins GS, Debidda M, Munshi NC, De Vivo I,. Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol 2008; 109: 394-402.
-
(2008)
Gynecol Oncol
, vol.109
, pp. 394-402
-
-
Wong, J.Y.1
Huggins, G.S.2
Debidda, M.3
Munshi, N.C.4
De Vivo, I.5
-
10
-
-
77953017932
-
Targeting cell metabolism in cancer patients
-
Vander Heiden MG,. Targeting cell metabolism in cancer patients. Sci Transl Med 2009; 2: 31ed1.
-
(2009)
Sci Transl Med
, vol.2
-
-
Vander Heiden, M.G.1
-
11
-
-
76249114497
-
E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation
-
Almeida A, Bolanos JP, Moncada S,. E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci USA; 107: 738-41.
-
Proc Natl Acad Sci USA
, vol.107
, pp. 738-741
-
-
Almeida, A.1
Bolanos, J.P.2
Moncada, S.3
-
12
-
-
4544230424
-
Characteristics of stem cells from human neuroblastoma cell lines and in tumors
-
DOI 10.1593/neo.04310
-
Walton JD, Kattan DR, Thomas SK, Spengler BA, Guo HF, Biedler JL, Cheung NK, Ross RA,. Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 2004; 6: 838-45. (Pubitemid 40041503)
-
(2004)
Neoplasia
, vol.6
, Issue.6
, pp. 838-845
-
-
Walton, J.D.1
Kattan, D.R.2
Thomas, S.K.3
Spengler, B.A.4
Guo, H.-F.5
Biedler, J.L.6
Cheung, N.-K.V.7
Ross, R.A.8
-
13
-
-
77349100153
-
The comparison of impedance-based method of cell proliferation monitoring with commonly used metabolic-based techniques
-
Vistejnova L, Dvorakova J, Hasova M, Muthny T, Velebny V, Soucek K, Kubala L,. The comparison of impedance-based method of cell proliferation monitoring with commonly used metabolic-based techniques. Neuro Endocrinol Lett 2009; 30 Suppl 1: 121-7.
-
(2009)
Neuro Endocrinol Lett
, vol.30
, Issue.SUPPL. 1
, pp. 121-127
-
-
Vistejnova, L.1
Dvorakova, J.2
Hasova, M.3
Muthny, T.4
Velebny, V.5
Soucek, K.6
Kubala, L.7
-
14
-
-
79958150830
-
Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes
-
Schmidt MM, Rohwedder A, Dringen R,. Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes. Neurotox Res 2011; 19: 628-37.
-
(2011)
Neurotox Res
, vol.19
, pp. 628-637
-
-
Schmidt, M.M.1
Rohwedder, A.2
Dringen, R.3
-
15
-
-
78650722178
-
Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?
-
Papandreou I, Goliasova T, Denko NC,. Anticancer drugs that target metabolism: is dichloroacetate the new paradigm? Int J Cancer 2011; 128: 1001-8.
-
(2011)
Int J Cancer
, vol.128
, pp. 1001-1008
-
-
Papandreou, I.1
Goliasova, T.2
Denko, N.C.3
-
16
-
-
78049487868
-
Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC
-
Stockwin LH, Yu SX, Borgel S, Hancock C, Wolfe TL, Phillips LR, Hollingshead MG, Newton DL,. Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC. Int J Cancer 2010; 127: 2510-9.
-
(2010)
Int J Cancer
, vol.127
, pp. 2510-2519
-
-
Stockwin, L.H.1
Yu, S.X.2
Borgel, S.3
Hancock, C.4
Wolfe, T.L.5
Phillips, L.R.6
Hollingshead, M.G.7
Newton, D.L.8
-
17
-
-
0035174254
-
Relationship between histopathological features. MYCN amplification, and prognosis: A UKCCSG study. United Kingdom Children Cancer Study Group
-
George RE, Variend S, Cullinane C, Cotterill SJ, McGuckin AG, Ellershaw C, Lunec J, Pearson AD,. Relationship between histopathological features. MYCN amplification, and prognosis: a UKCCSG study. United Kingdom Children Cancer Study Group. Med Pediatr Oncol 2001; 36: 169-76.
-
(2001)
Med Pediatr Oncol
, vol.36
, pp. 169-176
-
-
George, R.E.1
Variend, S.2
Cullinane, C.3
Cotterill, S.J.4
McGuckin, A.G.5
Ellershaw, C.6
Lunec, J.7
Pearson, A.D.8
-
18
-
-
33847251953
-
New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts
-
Pagano A, Castelnuovo M, Tortelli F, Ferrari R, Dieci G, Cancedda R,. New small nuclear RNA gene-like transcriptional units as sources of regulatory transcripts. PLoS Genet 2007; 3: e1.
-
(2007)
PLoS Genet
, vol.3
-
-
Pagano, A.1
Castelnuovo, M.2
Tortelli, F.3
Ferrari, R.4
Dieci, G.5
Cancedda, R.6
-
19
-
-
77957834981
-
An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells
-
Castelnuovo M, Massone S, Tasso R, Fiorino G, Gatti M, Robello M, Gatta E, Berger A, Strub K, Florio T, Dieci G, Cancedda R, et al. An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells. FASEB J 2010; 24: 4033-46.
-
(2010)
FASEB J
, vol.24
, pp. 4033-4046
-
-
Castelnuovo, M.1
Massone, S.2
Tasso, R.3
Fiorino, G.4
Gatti, M.5
Robello, M.6
Gatta, E.7
Berger, A.8
Strub, K.9
Florio, T.10
Dieci, G.11
Cancedda, R.12
-
20
-
-
77953285316
-
Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells
-
Madhok BM, Yeluri S, Perry SL, Hughes TA, Jayne DG,. Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells. Br J Cancer 2010; 102: 1746-52.
-
(2010)
Br J Cancer
, vol.102
, pp. 1746-1752
-
-
Madhok, B.M.1
Yeluri, S.2
Perry, S.L.3
Hughes, T.A.4
Jayne, D.G.5
-
21
-
-
0036353076
-
Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells
-
Liu TJ, Lin SY, Chau YP,. Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells. Toxicol Appl Pharmacol 2002; 182: 116-25.
-
(2002)
Toxicol Appl Pharmacol
, vol.182
, pp. 116-125
-
-
Liu, T.J.1
Lin, S.Y.2
Chau, Y.P.3
-
22
-
-
33646830260
-
Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children
-
DOI 10.1542/peds.2005-1226
-
Stacpoole PW, Kerr DS, Barnes C, Bunch ST, Carney PR, Fennell EM, Felitsyn NM, Gilmore RL, Greer M, Henderson GN, Hutson AD, Neiberger RE, et al. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 2006; 117: 1519-31. (Pubitemid 46071378)
-
(2006)
Pediatrics
, vol.117
, Issue.5
, pp. 1519-1531
-
-
Stacpoole, P.W.1
Kerr, D.S.2
Barnes, C.3
Bunch, S.4
Carney, P.R.5
Fennell, E.M.6
Felitsyn, N.M.7
Gilmore, R.L.8
Greer, M.9
Henderson, G.N.10
Hutson, A.D.11
Neiberger, R.E.12
O'Brien, R.G.13
Perkins, L.A.14
Quisling, R.G.15
Shroads, A.L.16
Shuster, J.J.17
Silverstein, J.H.18
Theriaque, D.W.19
Valenstein, E.20
more..
-
23
-
-
0023749178
-
Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease
-
Wargovich TJ, MacDonald RG, Hill JA, Feldman RL, Stacpoole PW, Pepine CJ,. Myocardial metabolic and hemodynamic effects of dichloroacetate in coronary artery disease. Am J Cardiol 1988; 61: 65-70.
-
(1988)
Am J Cardiol
, vol.61
, pp. 65-70
-
-
Wargovich, T.J.1
MacDonald, R.G.2
Hill, J.A.3
Feldman, R.L.4
Stacpoole, P.W.5
Pepine, C.J.6
-
24
-
-
33646202306
-
Dichloroacetate causes toxic neuropathy in MELAS: A randomized, controlled clinical trial
-
DOI 10.1212/01.wnl.0000196641.05913.27, PII 0000611420060214000009
-
Kaufmann P, Engelstad K, Wei Y, Jhung S, Sano MC, Shungu DC, Millar WS, Hong X, Gooch CL, Mao X, Pascual JM, Hirano M, et al. Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology 2006; 66: 324-30. (Pubitemid 43739931)
-
(2006)
Neurology
, vol.66
, Issue.3
, pp. 324-330
-
-
Kaufmann, P.1
Engelstad, K.2
Wei, Y.3
Jhung, S.4
Sano, M.C.5
Shungu, D.C.6
Millar, W.S.7
Hong, X.8
Gooch, C.L.9
Mao, X.10
Pascual, J.M.11
Hirano, M.12
Stacpoole, P.W.13
DiMauro, S.14
De Vivo, D.C.15
-
25
-
-
0031926903
-
Pharmacokinetics, metabolism and toxicology of dichloroacetate
-
Stacpoole PW, Henderson GN, Yan Z, Cornett R, James MO,. Pharmacokinetics, metabolism and toxicology of dichloroacetate. Drug Metab Rev 1998; 30: 499-539.
-
(1998)
Drug Metab Rev
, vol.30
, pp. 499-539
-
-
Stacpoole, P.W.1
Henderson, G.N.2
Yan, Z.3
Cornett, R.4
James, M.O.5
-
26
-
-
34047144925
-
Cancer patients opt for unapproved drug
-
DOI 10.1038/446474a, PII 446474A
-
Pearson H,. Cancer patients opt for unapproved drug. Nature 2007; 446: 474-5. (Pubitemid 46514699)
-
(2007)
Nature
, vol.446
, Issue.7135
, pp. 474-475
-
-
Pearson, H.1
-
27
-
-
0024148694
-
Mitochondrial membrane potential in living cells
-
Chen LB,. Mitochondrial membrane potential in living cells. Annu Rev Cell Biol 1988; 4: 155-81. (Pubitemid 19139255)
-
(1988)
Annual Review of Cell Biology
, vol.4
, pp. 155-181
-
-
Chen, L.B.1
-
28
-
-
77952963702
-
H(2)O(2)-mediated cytotoxicity of pharmacologic ascorbate concentrations to neuroblastoma cells: Potential role of lactate and ferritin
-
Deubzer B, Mayer F, Kuci Z, Niewisch M, Merkel G, Handgretinger R, Bruchelt G,. H(2)O(2)-mediated cytotoxicity of pharmacologic ascorbate concentrations to neuroblastoma cells: potential role of lactate and ferritin. Cell Physiol Biochem 2010; 25: 767-74.
-
(2010)
Cell Physiol Biochem
, vol.25
, pp. 767-774
-
-
Deubzer, B.1
Mayer, F.2
Kuci, Z.3
Niewisch, M.4
Merkel, G.5
Handgretinger, R.6
Bruchelt, G.7
|