Human-to-mouse prion-like propagation of mutant huntingtin protein

Acta Neuropathologica

Volumn 132, Issue 4, 2016, Pages 577-592

  Jeon, Iksoo ^a   Cicchetti, Francesca ^b,c   Cisbani, Giulia ^b   Lee, Suji ^a   Li, Endan ^a   Bae, Jiwoo ^a   Lee, Nayeon ^a   Li, Ling ^a   Im, Wooseok ^d   Kim, Manho ^d   Kim, Hyun Sook ^a   Oh, Seung Hun ^a   Kim, Tae Aug ^a   Ko, Jung Jae ^a   Aubé, Benoit ^b   Oueslati, Abid ^b,c   Kim, Yun Joong ^e   Song, Jihwan ^a  

^a CHA University   (South Korea)

^b Université Laval   (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

^d Seoul National University Hospital   (South Korea)

^e Hallym University   (South Korea)

Author keywords

Exosomes; Full length mutant huntingtin; Human fibroblasts; Human induced pluripotent stem cells; Huntington s disease

Indexed keywords

HUNTINGTIN; MUTANT PROTEIN; PROTEIN AGGREGATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CAG REPEAT; COCULTURE; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS STRIATUM; EXOSOME; FIBROBLAST; GLIOSIS; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; INDUCED PLURIPOTENT STEM CELL; INFLAMMATION; MALE; MEDIUM SPINY NEURON; MOTOR DYSFUNCTION; MOUSE; NEURAL STEM CELL; NEWBORN; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRION DISEASE; PRIORITY JOURNAL; ANIMAL; BRAIN; CASE REPORT; CHILD; CYTOLOGY; DISEASE MODEL; HUNTINGTON DISEASE; METABOLISM; NERVE CELL; PATHOLOGY;

ANIMALS; BRAIN; CHILD; DISEASE MODELS, ANIMAL; HUMANS; HUNTINGTIN PROTEIN; HUNTINGTON DISEASE; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE; MUTANT PROTEINS; NEURONS;

EID: 84970005386     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-016-1582-9     Document Type: Article

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