11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease

Neurobiology of Aging

Volumn 44, Issue , 2016, Pages 53-61

  Kreisl, William C ^a   Lyoo, Chul Hyoung ^a   Liow, Jeih San ^a   Wei, Monica ^a   Snow, Joseph ^a   Page, Emily ^a   Jenko, Kimberly J ^a   Morse, Cheryl L ^a   Zoghbi, Sami S ^a   Pike, Victor W ^a   Turner, R Scott ^b   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Neuroinflammation; PET imaging

Indexed keywords

CARBON PBR28 C 11; CARRIER PROTEIN; TRACER; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR; ACETAMIDE DERIVATIVE; BIOLOGICAL MARKER; CARBON; N-(2-METHOXYBENZYL)-N-(4-PHENOXYPYRIDIN-3-YL)ACETAMIDE; PROTEIN BINDING; PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TSPO PROTEIN, HUMAN;

AGED; ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG PROTEIN BINDING; ENTORHINAL CORTEX; FEMALE; FOLLOW UP; HIPPOCAMPUS; HUMAN; INFERIOR PARIETAL LOBULE; INFERIOR TEMPORAL CORTEX; LONGITUDINAL STUDY; MALE; OCCIPITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRECUNEUS; PRIORITY JOURNAL; BRAIN; DIAGNOSTIC IMAGING; METABOLISM; MIDDLE AGED; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING;

ACETAMIDES; AGED; ALZHEIMER DISEASE; BIOMARKERS; BRAIN; CARBON RADIOISOTOPES; DISEASE PROGRESSION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROIMAGING; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRIDINES; RADIOPHARMACEUTICALS; RECEPTORS, GABA;

EID: 84969932026     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2016.04.011     Document Type: Article

References (34)

1. Albert M.S., DeKosky S.T., Dickson D., Dubois B., Feldman H.H., Fox N.C., Gamst A., Holtzman D.M., Jagust W.J., Petersen R.C., Snyder P.J., Carrillo M.C., Thies B., Phelps C.H. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:270-279.
2. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Statist. Soc. B 1995, 57:289-300.
3. Braak H., Braak E., Bohl J., Lang W. Alzheimer's disease: amyloid plaques in the cerebellum. J. Neurol. Sci. 1989, 93:277-287.
4. Cagnin A., Brooks D.J., Kennedy A.M., Gunn R.N., Myers R., Turkheimer F.E., Jones T., Banati R.B. In-vivo measurement of activated microglia in dementia. Lancet 2001, 358:461-467.
5. Carter S.F., Scholl M., Almkvist O., Wall A., Engler H., Langstrom B., Nordberg A. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG. J. Nucl. Med. 2012, 53:37-46.
6. Collste K., Forsberg A., Varrone A., Amini N., Aeinehband S., Yakushev I., Halldin C., Farde L., Cervenka S. Test-retest reproducibility of [(11)C]PBR28 binding to TSPO in healthy control subjects. Eur. J. Nucl. Med. Mol. Imaging 2016, 43:173-183.
7. Cosenza-Nashat M., Zhao M.L., Suh H.S., Morgan J., Natividad R., Morgello S., Lee S.C. Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol. Appl. Neurobiol. 2009, 35:306-328.
8. Edison P., Archer H.A., Gerhard A., Hinz R., Pavese N., Turkheimer F.E., Hammers A., Tai Y.F., Fox N., Kennedy A., Rossor M., Brooks D.J. Microglia, amyloid, and cognition in Alzheimer's disease: an [11C](R)PK11195-PET and [11C]PIB-PET study. Neurobiol. Dis. 2008, 32:412-419.
9. Fan Z., Okello A.A., Brooks D.J., Edison P. Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease. Brain 2015, 138:3685-3698.
10. Fujita M., Imaizumi M., Zoghbi S.S., Fujimura Y., Farris A.G., Suhara T., Hong J., Pike V.W., Innis R.B. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation. Neuroimage 2008, 40:43-52.
11. Ghosh S., Wu M.D., Shaftel S.S., Kyrkanides S., LaFerla F.M., Olschowka J.A., O'Banion M.K. Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J. Neurosci. 2013, 33:5053-5064.
12. Jack C.R., Lowe V.J., Senjem M.L., Weigand S.D., Kemp B.J., Shiung M.M., Knopman D.S., Boeve B.F., Klunk W.E., Mathis C.A., Petersen R.C. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 2008, 131:665-680.
13. Jack C.R., Wiste H.J., Lesnick T.G., Weigand S.D., Knopman D.S., Vemuri P., Pankratz V.S., Senjem M.L., Gunter J.L., Mielke M.M., Lowe V.J., Boeve B.F., Petersen R.C. Brain β-amyloid load approaches a plateau. Neurology 2013, 80:890-896.
14. Kreisl W.C., Jenko K.J., Hines C.S., Hyoung Lyoo C., Corona W., Morse C.L., Zoghbi S.S., Hyde T., Kleinman J.E., Pike V.W., McMahon F.J., Innis R.B. A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J. Cereb. Blood Flow Metab. 2013, 33:53-58.
15. Kreisl W.C., Lyoo C.H., McGwier M., Snow J., Jenko K.J., Kimura N., Corona W., Morse C.L., Zoghbi S.S., Pike V.W., McMahon F.J., Turner R.S., Innis R.B. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease. Brain 2013, 136:2228-2238. Biomarkers Consortium, P.E.T.R.P.T.
16. Kumar A., Muzik O., Shandal V., Chugani D., Chakraborty P., Chugani H.T. Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET. J. Neuroinflammation 2012, 9:232.
17. Li Y., Tan M.S., Jiang T., Tan L. Microglia in Alzheimer's disease. Biomed. Res. Int. 2014, 2014:437483.
18. Lyoo C.H., Ikawa M., Liow J.S., Zoghbi S.S., Morse C.L., Pike V.W., Fujita M., Innis R.B., Kreisl W.C. Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein. J. Nucl. Med. 2015, 56:701-706.
19. Maezawa I., Zimin P.I., Wulff H., Jin L.W. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J. Biol. Chem. 2011, 286:3693-3706.
20. Marlatt M.W., Bauer J., Aronica E., van Haastert E.S., Hoozemans J.J., Joels M., Lucassen P.J. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural Plast. 2014, 2014:693851.
21. Matousek S.B., Ghosh S., Shaftel S.S., Kyrkanides S., Olschowka J.A., O'Banion M.K. Chronic IL-1beta-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 2012, 7:156-164.
22. McGeer E.G., McGeer P.L. Inflammatory processes in Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 2003, 27:741-749.
23. McGeer P.L., McGeer E.G. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol. 2013, 126:479-497.
24. McKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Kawas C.H., Klunk W.E., Koroshetz W.J., Manly J.J., Mayeux R., Mohs R.C., Morris J.C., Rossor M.N., Scheltens P., Carrillo M.C., Thies B., Weintraub S., Phelps C.H. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:263-269.
25. Okello A., Edison P., Archer H.A., Turkheimer F.E., Kennedy J., Bullock R., Walker Z., Kennedy A., Fox N., Rossor M., Brooks D.J. Microglial activation and amyloid deposition in mild cognitive impairment: a PET study. Neurology 2009, 72:56-62.
26. Owen D.R., Yeo A.J., Gunn R.N., Song K., Wadsworth G., Lewis A., Rhodes C., Pulford D.J., Bennacef I., Parker C.A., StJean P.L., Cardon L.R., Mooser V.E., Matthews P.M., Rabiner E.A., Rubio J.P. An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J. Cereb. Blood Flow Metab. 2012, 32:1-5.
27. Park E., Gallezot J.D., Delgadillo A., Liu S., Planeta B., Lin S.F., O'Connor K.C., Lim K., Lee J.Y., Chastre A., Chen M.K., Seneca N., Leppert D., Huang Y., Carson R.E., Pelletier D. (11)C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. Eur. J. Nucl. Med. Mol. Imaging 2015, 42:1081-1092.
28. Price J.C., Klunk W.E., Lopresti B.J., Lu X., Hoge J.A., Ziolko S.K., Holt D.P., Meltzer C.C., DeKosky S.T., Mathis C.A. Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J. Cereb. Blood Flow Metab. 2005, 25:1528-1547.
29. Sasaki A., Yamaguchi H., Ogawa A., Sugihara S., Nakazato Y. Microglial activation in early stages of amyloid beta protein deposition. Acta Neuropathol. 1997, 94:316-322.
30. Thal D.R., Rub U., Orantes M., Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 2002, 58:1791-1800.
31. Thomas B.A., Erlandsson K., Modat M., Thurfjell L., Vandenberghe R., Ourselin S., Hutton B.F. The importance of appropriate partial volume correction for PET quantification in Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging 2011, 38:1104-1119.
32. van Berckel B.N., Ossenkoppele R., Tolboom N., Yaqub M., Foster-Dingley J.C., Windhorst A.D., Scheltens P., Lammertsma A.A., Boellaard R. Longitudinal amyloid imaging using 11C-PiB: methodologic considerations. J. Nucl. Med. 2013, 54:1570-1576.
33. Wiley C.A., Lopresti B.J., Venneti S., Price J., Klunk W.E., DeKosky S.T., Mathis C.A. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch. Neurol. 2009, 66:60-67.
34. Wood P.L. The cerebellum in AD. Neuroinflammation 2003, 295-300. Humana Press, New Jersey. P.L. Wood (Ed.).