Test–retest reproducibility of [11C]PBR28 binding to TSPO in healthy control subjects

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 43, Issue 1, 2016, Pages 173-183

  Collste, K ^a   Forsberg, A ^a   Varrone, A ^a   Amini, N ^a   Aeinehband, S ^a   Yakushev, I ^a,b   Halldin, C ^a   Farde, L ^a   Cervenka, S ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

11C; Brain imaging; PBR28; PET; Test retest

Indexed keywords

CARBON 11; PBR28 C 11; PROTEIN; RADIOLIGAND; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG; (METHYL-(11)C)N-ACETYL-N-(2-METHOXYBENZYL)-2-PHENOXY-5-PYRIDINAMINE; 4 AMINOBUTYRIC ACID RECEPTOR; CARBON; PROTEIN BINDING; PYRIMIDINE DERIVATIVE; TSPO PROTEIN, HUMAN;

ADULT; ARTICLE; BINDING AFFINITY; BRAIN REGION; CIRCADIAN RHYTHM; CORRELATION COEFFICIENT; FEMALE; GENOTYPE; GRAY MATTER; HUMAN; MALE; NEUROIMAGING; NORMAL HUMAN; RADIOACTIVITY; RADIOLOGICAL PARAMETERS; REGIONAL VOLUMES OF DISTRIBUTION; REPRODUCIBILITY; STANDARD UPTAKE VALUE; TEST RETEST RELIABILITY; VOXEL BASED MORPHOMETRY; WAVELET AIDED PARAMETRIC IMAGING; YOUNG ADULT; CLINICAL TRIAL; GENETICS; METABOLISM;

CARBON RADIOISOTOPES; FEMALE; GENOTYPE; HEALTHY VOLUNTEERS; HUMANS; MALE; PROTEIN BINDING; PYRIMIDINES; RECEPTORS, GABA; REPRODUCIBILITY OF RESULTS; YOUNG ADULT;

EID: 84951907345     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-015-3149-8     Document Type: Article

References (34)

1. Raivich G. Like cops on the beat: the active role of resting microglia. Trends Neurosci. 2005;28:571–3.
2. Venneti S, Lopresti BJ, Wiley CA. The peripheral benzodiazepine receptor (translocator protein 18kDa) in microglia: from pathology to imaging. Prog Neurobiol. 2006;80:308–22.
3. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapère JJ, Lindemann P, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci. 2006;27:402–9.
4. Cagnin A, Kassiou M, Meikle SR, Banati RB. Positron emission tomography imaging of neuroinflammation. Neurotherapeutics. 2007;4:443–52.
5. Imaizumi M, Briard E, Zoghbi SS, Gourley JP, Hong J, Fujimura Y, et al. Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors. Neuroimage. 2008;39:1289–98.
6. Jučaite A, Cselényi Z, Arvidsson A, Ahlberg G, Julin P, Varnäs K, et al. Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain – a PET study in control subjects. EJNMMI Res. 2012;2:15.
7. Hirvonen J, Aalto S, Lumme V, Någren K, Kajander J, Vilkman H, et al. Measurement of striatal and thalamic dopamine D2 receptor binding with 11C-raclopride. Nucl Med Commun. 2003;24:1207–14.
8. Owen DR, Matthews PM. Imaging brain microglial activation using positron emission tomography and translocator protein-specific radioligands. Int Rev Neurobiol. 2011;101:19–39.
9. Fujita M, Imaizumi M, Zoghbi SS, Fujimura Y, Farris AG, Suhara T, et al. Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for inflammation. Neuroimage. 2008;40:43–52
10. Kreisl WC, Fujita M, Fujimura Y, Kimura N, Jenko KJ, Kannan P, et al. Comparison of [11C]-(R)-PK 11195 and [11C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission tomographic imaging of this inflammation biomarker. Neuroimage. 2010;49:2924–32.
11. Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, et al. Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates. Neuroimage. 2012;63:232–9.
12. Kreisl WC, Lyoo CH, McGwier M, Snow J, Jenko KJ, Kimura N, et al. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease. Brain. 2013;136:2228–38.
13. Oh U, Fujita M, Ikonomidou VN, Evangelou IE, Matsuura E, Harberts E, et al. Translocator protein PET imaging for glial activation in multiple sclerosis. J Neuroimmune Pharmacol. 2011;6:354–61.
14. Fujita M, Mahanty S, Zoghbi SS, Ferraris Araneta MD, Hong J, Pike VW, et al. PET reveals inflammation around calcified Taenia solium granulomas with perilesional edema. PLoS One. 2013;8:e74052.
15. Nakao A. Temporal regulation of cytokines by the circadian clock. J Immunol Res. 2014;2014:614529
16. Curtis AM, Bellet MM, Sassone-Corsi P, O’Neill LA. Circadian clock proteins and immunity. Immunity. 2014;40:178–86.
17. Owen DR, Yeo AJ, Gunn RN, Song K, Wadsworth G, Lewis A, et al. An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28. J Cereb Blood Flow Metab. 2012;32:1–5.
18. Briard E, Zoghbi SS, Imaizumi M, Gourley JP, Shetty HU, Hong J, et al. Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem. 2008;51:17–30
19. Bergström M, Boëthius J, Eriksson L, Greitz T, Ribbe T, Widén L. Head fixation device for reproducible position alignment in transmission CT and positron emission tomography. J Comput Assist Tomogr. 1981;5:136–41.
20. Varrone A, Sjöholm N, Eriksson L, Gulyás B, Halldin C, Farde L. Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT. Eur J Nucl Med Mol Imaging. 2009;36:1639–50.
21. Farde L, Eriksson L, Blomquist G, Halldin C. Kinetic analysis of central [11C]raclopride binding to D2-dopamine receptors studied by PET – a comparison to the equilibrium analysis. J Cereb Blood Flow Metab. 1989;9:696–708.
22. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002;15:273–89.
23. Innis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab. 2007;27:1533–9.
24. Cselényi Z, Olsson H, Halldin C, Gulyás B, Farde L. A comparison of recent parametric neuroreceptor mapping approaches based on measurements with the high affinity PET radioligands [11C]FLB 457 and [11C]WAY 100635. Neuroimage. 2006;32:1690–708.
25. Schain M, Tóth M, Cselényi Z, Arakawa R, Halldin C, Farde L, et al. Improved mapping and quantification of serotonin transporter availability in the human brainstem with the HRRT. Eur J Nucl Med Mol Imaging. 2013;40:228–37.
26. Turkheimer FE, Aston JA, Banati RB, Riddell C, Cunningham VJ. A linear wavelet filter for parametric imaging with dynamic PET. IEEE Trans Med Imaging. 2003;22:289–301.
27. McGraw KO, Wong SP. Forming inferences about some intraclass correlation coefficients. Psychol Methods. 1996;1:30–46.
28. Narendran R, Lopresti BJ, Mason NS, Deuitch L, Paris J, Himes ML, et al. Cocaine abuse in humans is not associated with increased microglial activation: an 18-kDa translocator protein positron emission tomography imaging study with [11C]PBR28. J Neurosci. 2014;34:9945–50.
29. Kreisl WC, Jenko KJ, Hines CS, Lyoo CH, Corona W, Morse CL, et al. A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J Cereb Blood Flow Metab. 2013;33:53–8.
30. Yoder KK, Nho K, Risacher SL, Kim S, Shen L, Saykin AJ. Influence of TSPO genotype on 11C-PBR28 standardized uptake values. J Nucl Med. 2013;54:1320–2.
31. Owen DR, Guo Q, Kalk NJ, Colasanti A, Kalogiannopoulou D, Dimber R, et al. Determination of [(11)C]PBR28 binding potential in vivo: a first human TSPO blocking study. J Cereb Blood Flow Metab. 2014;34:989–94.
32. Haus E, Smolensky MH. Biologic rhythms in the immune system. Chronobiol Int. 1999;16:581–622.
33. Agorastos A, Hauger RL, Barkauskas DA, Moeller-Bertram T, Clopton PL, Haji U, et al. Circadian rhythmicity, variability and correlation of interleukin-6 levels in plasma and cerebrospinal fluid of healthy men. Psychoneuroendocrinology. 2014;44:71–82.
34. Schain M, Benjaminsson S, Varnäs K, Forsberg A, Halldin C, Lansner A, et al. Arterial input function derived from pairwise correlations between PET-image voxels. J Cereb Blood Flow Metab. 2013;33:1058–65.