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Volumn 18, Issue 6, 2016, Pages 657-667

Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; POLYCYSTIN 2; PROTEIN KINASE LKB1; MTOR PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

EID: 84969857891     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3360     Document Type: Article
Times cited : (113)

References (74)
  • 1
    • 33947384151 scopus 로고    scopus 로고
    • Overview of structure and function of mammalian cilia
    • Satir, P. & Christensen, S. T. Overview of structure and function of mammalian cilia. Annu. Rev. Physiol. 69, 377-400 (2007).
    • (2007) Annu. Rev. Physiol. , vol.69 , pp. 377-400
    • Satir, P.1    Christensen, S.T.2
  • 3
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: A signalling centre during vertebrate development
    • Goetz, S. C. & Anderson, K. V. The primary cilium: A signalling centre during vertebrate development. Nat. Rev. Genet. 11, 331-344 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 4
    • 84928626421 scopus 로고    scopus 로고
    • SnapShot: Sensing and signaling by cilia
    • Zimmerman, K. & Yoder, B. K. SnapShot: sensing and signaling by cilia. Cell 161, 692 (2015).
    • (2015) Cell , vol.161 , pp. 692
    • Zimmerman, K.1    Yoder, B.K.2
  • 7
    • 84856230537 scopus 로고    scopus 로고
    • Mechanisms regulating cilia growth and cilia function in endothelial cells
    • Abdul-Majeed, S., Moloney, B. C. & Nauli, S. M. Mechanisms regulating cilia growth and cilia function in endothelial cells. Cell Mol. Life Sci. 69, 165-173 (2012).
    • (2012) Cell Mol. Life Sci. , vol.69 , pp. 165-173
    • Abdul-Majeed, S.1    Moloney, B.C.2    Nauli, S.M.3
  • 8
    • 84926434329 scopus 로고    scopus 로고
    • Endothelial cilia are essential for developmental vascular integrity in zebrafish
    • Kallakuri, S. et al. Endothelial cilia are essential for developmental vascular integrity in zebrafish. J. Am. Soc. Nephrol. 26, 864-875 (2015).
    • (2015) J. Am. Soc. Nephrol. , vol.26 , pp. 864-875
    • Kallakuri, S.1
  • 9
    • 33745710680 scopus 로고    scopus 로고
    • Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular CaC 2 and cAMP signaling
    • Masyuk, A. I. et al. Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular CaC 2 and cAMP signaling. Gastroenterology 131, 911-920 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 911-920
    • Masyuk, A.I.1
  • 10
    • 0038784537 scopus 로고    scopus 로고
    • Two populations of node monocilia initiate left-right asymmetry in the mouse
    • McGrath, J., Somlo, S., Makova, S., Tian, X. & Brueckner, M. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 114, 61-73 (2003).
    • (2003) Cell , vol.114 , pp. 61-73
    • McGrath, J.1    Somlo, S.2    Makova, S.3    Tian, X.4    Brueckner, M.5
  • 11
    • 0037317302 scopus 로고    scopus 로고
    • Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
    • Nauli, S. M. et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33, 129-137 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 129-137
    • Nauli, S.M.1
  • 13
    • 84949570349 scopus 로고    scopus 로고
    • Discerning the role of mechanosensors in regulating proximal tubule function
    • Raghavan, V. & Weisz, O. A. Discerning the role of mechanosensors in regulating proximal tubule function. Am. J. Physiol. Renal Physiol. 310, F1-F5 (2016).
    • (2016) Am. J. Physiol. Renal Physiol. , vol.310 , pp. F1-F5
    • Raghavan, V.1    Weisz, O.A.2
  • 14
    • 78349286779 scopus 로고    scopus 로고
    • The cell biology of polycystic kidney disease
    • Chapin, H. C. & Caplan, M. J. The cell biology of polycystic kidney disease. J. Cell Biol. 191, 701-710 (2010).
    • (2010) J. Cell Biol. , vol.191 , pp. 701-710
    • Chapin, H.C.1    Caplan, M.J.2
  • 15
    • 0037377655 scopus 로고    scopus 로고
    • Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice
    • Brown, N. E. & Murcia, N. S. Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice. Kidney Int. 63, 1220-1229 (2003).
    • (2003) Kidney Int. , vol.63 , pp. 1220-1229
    • Brown, N.E.1    Murcia, N.S.2
  • 16
    • 0023204539 scopus 로고
    • Cyst formation and growth in autosomal dominant polycystic kidney disease
    • Grantham, J. J., Geiser, J. L. & Evan, A. P. Cyst formation and growth in autosomal dominant polycystic kidney disease. Kidney Int. 31, 1145-1152 (1987).
    • (1987) Kidney Int. , vol.31 , pp. 1145-1152
    • Grantham, J.J.1    Geiser, J.L.2    Evan, A.P.3
  • 17
    • 78149259013 scopus 로고    scopus 로고
    • Primary cilia regulate mTORC1 activity and cell size through Lkb1
    • Boehlke, C. et al. Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat. Cell Biol. 12, 1115-1122 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 1115-1122
    • Boehlke, C.1
  • 18
    • 80052262467 scopus 로고    scopus 로고
    • Polycystic kidney disease: Pathogenesis and potential therapies
    • Takiar, V. & Caplan, M. J. Polycystic kidney disease: pathogenesis and potential therapies. Biochim. Biophys. Acta 1812, 1337-1343 (2011).
    • (2011) Biochim. Biophys. Acta , vol.1812 , pp. 1337-1343
    • Takiar, V.1    Caplan, M.J.2
  • 19
    • 84880376355 scopus 로고    scopus 로고
    • Emerging regulation and functions of autophagy
    • Boya, P., Reggiori, F. & Codogno, P. Emerging regulation and functions of autophagy. Nat. Cell Biol. 15, 713-720 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 713-720
    • Boya, P.1    Reggiori, F.2    Codogno, P.3
  • 20
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: Renovation of cells and tissues
    • Mizushima, N. & Komatsu, M. Autophagy: renovation of cells and tissues. Cell 147, 728-741 (2011).
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 21
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macroautophagy
    • Yang, Z. & Klionsky, D. J. Eaten alive: A history of macroautophagy. Nat. Cell Biol. 12, 814-822 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 22
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer, G., Mariño, G. & Levine, B. Autophagy and the integrated stress response. Mol. Cell 40, 280-293 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 23
    • 84942552963 scopus 로고    scopus 로고
    • Regulation of autophagy by amino acids and MTOR-dependent signal transduction
    • Meijer, A. J., Lorin, S., Blommaart, E. F. & Codogno, P. Regulation of autophagy by amino acids and MTOR-dependent signal transduction. Amino Acids 47, 2037-2063 (2015).
    • (2015) Amino Acids , vol.47 , pp. 2037-2063
    • Meijer, A.J.1    Lorin, S.2    Blommaart, E.F.3    Codogno, P.4
  • 24
    • 79955441991 scopus 로고    scopus 로고
    • Balancing forces: Architectural control of mechanotransduction
    • DuFort, C. C., Paszek, M. J. & Weaver, V. M. Balancing forces: architectural control of mechanotransduction. Nat. Rev. Mol. Cell Biol. 12, 308-319 (2011).
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 308-319
    • DuFort, C.C.1    Paszek, M.J.2    Weaver, V.M.3
  • 25
    • 0026523705 scopus 로고
    • Mechanotransduction
    • French, A. S. Mechanotransduction. Annu. Rev. Physiol. 54, 135-152 (1992).
    • (1992) Annu. Rev. Physiol. , vol.54 , pp. 135-152
    • French, A.S.1
  • 26
    • 84863393597 scopus 로고    scopus 로고
    • Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
    • He, C. et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature 481, 511-515 (2012).
    • (2012) Nature , vol.481 , pp. 511-515
    • He, C.1
  • 27
    • 78649821253 scopus 로고    scopus 로고
    • Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy
    • Hussain, S. N. et al. Mechanical ventilation-induced diaphragm disuse in humans triggers autophagy. Am. J. Respir. Crit. Care Med. 182, 1377-1386 (2010).
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , pp. 1377-1386
    • Hussain, S.N.1
  • 28
    • 84902208708 scopus 로고    scopus 로고
    • Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy
    • Zaglia, T. et al. Atrogin-1 deficiency promotes cardiomyopathy and premature death via impaired autophagy. J. Clin. Invest. 124, 2410-2424 (2014).
    • (2014) J. Clin. Invest. , vol.124 , pp. 2410-2424
    • Zaglia, T.1
  • 29
    • 84866946189 scopus 로고    scopus 로고
    • Mechanical stress meets autophagy: Potential implications for physiology and pathology
    • King, J. S. Mechanical stress meets autophagy: potential implications for physiology and pathology. Trends Mol. Med. 18, 583-588 (2012).
    • (2012) Trends Mol. Med. , vol.18 , pp. 583-588
    • King, J.S.1
  • 30
    • 84885661260 scopus 로고    scopus 로고
    • Functional interaction between autophagy and ciliogenesis
    • Pampliega, O. et al. Functional interaction between autophagy and ciliogenesis. Nature 502, 194-200 (2013).
    • (2013) Nature , vol.502 , pp. 194-200
    • Pampliega, O.1
  • 31
    • 84885638436 scopus 로고    scopus 로고
    • Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites
    • Tang, Z. et al. Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature 502, 254-257 (2013).
    • (2013) Nature , vol.502 , pp. 254-257
    • Tang, Z.1
  • 32
    • 84874828473 scopus 로고    scopus 로고
    • The ciliary flow sensor and polycystic kidney disease
    • Kotsis, F., Boehlke, C. & Kuehn, E. W. The ciliary flow sensor and polycystic kidney disease. Nephrol. Dial. Transplant. 28, 518-526 (2013).
    • (2013) Nephrol. Dial. Transplant. , vol.28 , pp. 518-526
    • Kotsis, F.1    Boehlke, C.2    Kuehn, E.W.3
  • 33
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).
    • (2000) EMBO J. , vol.19 , pp. 5720-5728
    • Kabeya, Y.1
  • 34
    • 85013763791 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
    • Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-222 (2016).
    • (2016) Autophagy , vol.12 , pp. 1-222
    • Klionsky, D.J.1
  • 35
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura, S., Noda, T. & Yoshimori, T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3, 452-460 (2007).
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 36
  • 37
    • 33746108329 scopus 로고    scopus 로고
    • Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
    • Tanida, I., Minematsu-Ikeguchi, N., Ueno, T. & Kominami, E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1, 84-91 (2005).
    • (2005) Autophagy , vol.1 , pp. 84-91
    • Tanida, I.1    Minematsu-Ikeguchi, N.2    Ueno, T.3    Kominami, E.4
  • 38
    • 84937637420 scopus 로고    scopus 로고
    • Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1
    • Jin, G. et al. Skp2-mediated RagA ubiquitination elicits a negative feedback to prevent amino-acid-dependent mTORC1 hyperactivation by recruiting GATOR1. Mol. Cell 58, 989-1000 (2015).
    • (2015) Mol. Cell , vol.58 , pp. 989-1000
    • Jin, G.1
  • 40
    • 84953853724 scopus 로고    scopus 로고
    • Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways
    • Wang, S., Livingston, M. J., Su, Y. & Dong, Z. Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways. Autophagy 11, 607-616 (2015).
    • (2015) Autophagy , vol.11 , pp. 607-616
    • Wang, S.1    Livingston, M.J.2    Su, Y.3    Dong, Z.4
  • 41
    • 0034735526 scopus 로고    scopus 로고
    • Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    • Pazour, G. J. et al. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J. Cell Biol. 151, 709-718 (2000).
    • (2000) J. Cell Biol. , vol.151 , pp. 709-718
    • Pazour, G.J.1
  • 42
    • 70349437416 scopus 로고    scopus 로고
    • Kinesin superfamily motor proteins and intracellular transport
    • Hirokawa, N., Noda, Y., Tanaka, Y. & Niwa, S. Kinesin superfamily motor proteins and intracellular transport. Nat. Rev. Mol. Cell Biol. 10, 682-696 (2009).
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 682-696
    • Hirokawa, N.1    Noda, Y.2    Tanaka, Y.3    Niwa, S.4
  • 43
    • 0005677775 scopus 로고
    • 3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes
    • Seglen, P. O. & Gordon, P. B. 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl Acad. Sci. USA 79, 1889-1892 (1982).
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 1889-1892
    • Seglen, P.O.1    Gordon, P.B.2
  • 44
    • 84879414522 scopus 로고    scopus 로고
    • The mechanisms of Hedgehog signalling and its roles in development and disease
    • Briscoe, J. & Therond, P. P. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat. Rev. Mol. Cell Biol. 14, 416-429 (2013).
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 416-429
    • Briscoe, J.1    Therond, P.P.2
  • 45
    • 79959794426 scopus 로고    scopus 로고
    • TRPP channels and polycystins
    • Hofherr, A. & Kottgen, M. TRPP channels and polycystins. Adv. Exp. Med. Biol. 704, 287-313 (2011).
    • (2011) Adv. Exp. Med. Biol. , vol.704 , pp. 287-313
    • Hofherr, A.1    Kottgen, M.2
  • 46
    • 84901682529 scopus 로고    scopus 로고
    • Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli
    • Jin, X. et al. Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli. Cell Mol. Life Sci. 71, 2165-2178 (2014).
    • (2014) Cell Mol. Life Sci. , vol.71 , pp. 2165-2178
    • Jin, X.1
  • 47
    • 85006195301 scopus 로고    scopus 로고
    • Cilia in autophagy and cancer
    • Cao, M. & Zhong, Q. Cilia in autophagy and cancer. Cilia 5, 4 (2016).
    • (2016) Cilia , vol.5 , pp. 4
    • Cao, M.1    Zhong, Q.2
  • 48
    • 84955516959 scopus 로고    scopus 로고
    • Autophagy and primary cilia: Dual interplay
    • Pampliega, O. & Cuervo, A. M. Autophagy and primary cilia: dual interplay. Curr. Opin. Cell Biol. 39, 1-7 (2016).
    • (2016) Curr. Opin. Cell Biol. , vol.39 , pp. 1-7
    • Pampliega, O.1    Cuervo, A.M.2
  • 49
    • 84923052703 scopus 로고    scopus 로고
    • Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells
    • Kim, E. S. et al. Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells. PLoS ONE 10, e0118190 (2015).
    • (2015) PLoS ONE , vol.10 , pp. e0118190
    • Kim, E.S.1
  • 50
    • 84890025789 scopus 로고    scopus 로고
    • Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction
    • Lam, H. C. et al. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J. Clin. Invest. 123, 5212-5230 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 5212-5230
    • Lam, H.C.1
  • 51
    • 0027163450 scopus 로고
    • Cell swelling and the sensitivity of autophagic proteolysis to inhibition by amino acids in isolated rat hepatocytes
    • Meijer, A. J. et al. Cell swelling and the sensitivity of autophagic proteolysis to inhibition by amino acids in isolated rat hepatocytes. Eur. J. Biochem. 215, 449-454 (1993).
    • (1993) Eur. J. Biochem. , vol.215 , pp. 449-454
    • Meijer, A.J.1
  • 52
    • 0038711645 scopus 로고    scopus 로고
    • Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver
    • vom Dahl, S. et al. Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver. J. Biol. Chem. 278, 27088-27095 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 27088-27095
    • Vom Dahl, S.1
  • 53
    • 79955626606 scopus 로고    scopus 로고
    • Autophagy protects the proximal tubule from degeneration and acute ischemic injury
    • Kimura, T. et al. Autophagy protects the proximal tubule from degeneration and acute ischemic injury. J. Am. Soc. Nephrol. 22, 902-913 (2011).
    • (2011) J. Am. Soc. Nephrol. , vol.22 , pp. 902-913
    • Kimura, T.1
  • 54
    • 21044455137 scopus 로고    scopus 로고
    • Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
    • Komatsu, M. et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169, 425-434 (2005).
    • (2005) J. Cell Biol. , vol.169 , pp. 425-434
    • Komatsu, M.1
  • 55
    • 84883740868 scopus 로고    scopus 로고
    • Uba1 functions in Atg7-and Atg3-independent autophagy
    • Chang, T. K. et al. Uba1 functions in Atg7-and Atg3-independent autophagy. Nat. Cell Biol. 15, 1067-1078 (2013).
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1067-1078
    • Chang, T.K.1
  • 56
    • 84952871017 scopus 로고    scopus 로고
    • Mevalonate pathway regulates cell size homeostasis and proteostasis through autophagy
    • Miettinen, T. P. & Bjorklund, M. Mevalonate pathway regulates cell size homeostasis and proteostasis through autophagy. Cell Rep. 13, 2610-2620 (2015).
    • (2015) Cell Rep. , vol.13 , pp. 2610-2620
    • Miettinen, T.P.1    Bjorklund, M.2
  • 57
    • 38149044992 scopus 로고    scopus 로고
    • Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells
    • Fader, C. M., Sanchez, D., Furlan, M. & Colombo, M. I. Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells. Traffic 9, 230-250 (2008).
    • (2008) Traffic , vol.9 , pp. 230-250
    • Fader, C.M.1    Sanchez, D.2    Furlan, M.3    Colombo, M.I.4
  • 58
    • 77950877404 scopus 로고    scopus 로고
    • Coordination of Rab8 and Rab11 in primary ciliogenesis
    • Knodler, A. et al. Coordination of Rab8 and Rab11 in primary ciliogenesis. Proc. Natl Acad. Sci. USA 107, 6346-6351 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 6346-6351
    • Knodler, A.1
  • 59
    • 84881192927 scopus 로고    scopus 로고
    • MTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
    • Zeng, H. et al. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature 499, 485-490 (2013).
    • (2013) Nature , vol.499 , pp. 485-490
    • Zeng, H.1
  • 60
    • 84866142024 scopus 로고    scopus 로고
    • Emerging role of autophagy in kidney function, diseases and aging
    • Huber, T. B. et al. Emerging role of autophagy in kidney function, diseases and aging. Autophagy 8, 1009-1031 (2012).
    • (2012) Autophagy , vol.8 , pp. 1009-1031
    • Huber, T.B.1
  • 61
    • 84893406789 scopus 로고    scopus 로고
    • Polycystic kidney disease: A case of suppressed autophagy?
    • Ravichandran, K. & Edelstein, C. L. Polycystic kidney disease: A case of suppressed autophagy? Semin. Nephrol. 34, 27-33 (2014).
    • (2014) Semin. Nephrol. , vol.34 , pp. 27-33
    • Ravichandran, K.1    Edelstein, C.L.2
  • 62
    • 84892613717 scopus 로고    scopus 로고
    • Autophagy in kidney health and disease
    • Wang, Z. & Choi, M. E. Autophagy in kidney health and disease. Antioxid. Redox Signal. 20, 519-537 (2014).
    • (2014) Antioxid. Redox Signal. , vol.20 , pp. 519-537
    • Wang, Z.1    Choi, M.E.2
  • 63
    • 77956261961 scopus 로고    scopus 로고
    • Polycystins and renovascular mechanosensory transduction
    • Patel, A. & Honore, E. Polycystins and renovascular mechanosensory transduction. Nat. Rev. Nephrol. 6, 530-538 (2010).
    • (2010) Nat. Rev. Nephrol. , vol.6 , pp. 530-538
    • Patel, A.1    Honore, E.2
  • 64
    • 84896790090 scopus 로고    scopus 로고
    • Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway
    • Cebotaru, V. et al. Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway. J. Biol. Chem. 289, 6404-6414 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 6404-6414
    • Cebotaru, V.1
  • 65
    • 84890345523 scopus 로고    scopus 로고
    • Primary cilia are specialized calcium signalling organelles
    • Delling, M., DeCaen, P. G., Doerner, J. F., Febvay, S. & Clapham, D. E. Primary cilia are specialized calcium signalling organelles. Nature 504, 311-314 (2013).
    • (2013) Nature , vol.504 , pp. 311-314
    • Delling, M.1    DeCaen, P.G.2    Doerner, J.F.3    Febvay, S.4    Clapham, D.E.5
  • 66
    • 0030707562 scopus 로고    scopus 로고
    • TOR signalling and control of cell growth
    • Thomas, G. & Hall, M. N. TOR signalling and control of cell growth. Curr. Opin. Cell Biol. 9, 782-787 (1997).
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 782-787
    • Thomas, G.1    Hall, M.N.2
  • 67
    • 84902176106 scopus 로고    scopus 로고
    • Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia
    • Raghavan, V., Rbaibi, Y., Pastor-Soler, N. M., Carattino, M. D. & Weisz, O. A. Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc. Natl Acad. Sci. USA 111, 8506-8511 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 8506-8511
    • Raghavan, V.1    Rbaibi, Y.2    Pastor-Soler, N.M.3    Carattino, M.D.4    Weisz, O.A.5
  • 69
    • 84884220705 scopus 로고    scopus 로고
    • Diverse autophagosome membrane sources coalesce in recycling endosomes
    • Puri, C., Renna, M., Bento, C. F., Moreau, K. & Rubinsztein, D. C. Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell 154, 1285-1299 (2013).
    • (2013) Cell , vol.154 , pp. 1285-1299
    • Puri, C.1    Renna, M.2    Bento, C.F.3    Moreau, K.4    Rubinsztein, D.C.5
  • 71
    • 46249126152 scopus 로고    scopus 로고
    • Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation
    • El Boustany, C. et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology 47, 2068-2077 (2008).
    • (2008) Hepatology , vol.47 , pp. 2068-2077
    • El Boustany, C.1
  • 72
    • 33750579753 scopus 로고    scopus 로고
    • Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction
    • Yoo, K. H. et al. Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction. Kidney Int. 70, 1735-1741 (2006).
    • (2006) Kidney Int. , vol.70 , pp. 1735-1741
    • Yoo, K.H.1
  • 73
    • 78049434336 scopus 로고    scopus 로고
    • Lipocalin 2 is essential for chronic kidney disease progression in mice and humans
    • Viau, A. et al. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J. Clin. Invest. 120, 4065-4076 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 4065-4076
    • Viau, A.1
  • 74
    • 84887479804 scopus 로고    scopus 로고
    • AKT2 is essential to maintain podocyte viability and function during chronic kidney disease
    • Canaud, G. et al. AKT2 is essential to maintain podocyte viability and function during chronic kidney disease. Nat. Med. 19, 1288-1296 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 1288-1296
    • Canaud, G.1


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