Discerning the role of mechanosensors in regulating proximal tubule function

American Journal of Physiology - Renal Physiology

Volumn 310, Issue 1, 2015, Pages F1-F5

  Raghavan, Venkatesan ^a   Weisz, Ora A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Cilia; Endocytosis; Glycocalyx; Mechanical stretch; Mechanosensation; Microvilli; Shear stress

Indexed keywords

AMMONIUM SULFATE; CALCIUM; CALCIUM CHANNEL; CHLORAL HYDRATE; INTEGRIN; PURINERGIC RECEPTOR; ION CHANNEL;

ACTIN FILAMENT; APICAL MEMBRANE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; EUKARYOTIC FLAGELLUM; FLOW RATE; FOCAL ADHESION; GAP JUNCTION; GLOMERULUS FILTRATION RATE; GLYCOCALYX; HUMAN; INTESTINE PRESSURE; ION TRANSPORT; KIDNEY BLOOD FLOW; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE CELL; KIDNEY TUBULE FUNCTION; MECHANOSENSING; MICROVILLUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR POTENTIAL; REVIEW; SHEAR STRESS; ANIMAL; CELL JUNCTION; CHANNEL GATING; EPITHELIUM CELL; INNERVATION; MECHANICAL STRESS; MECHANORECEPTOR; MECHANOTRANSDUCTION; METABOLISM; PHYSIOLOGY; PRESSURE;

ANIMALS; EPITHELIAL CELLS; HUMANS; INTEGRINS; INTERCELLULAR JUNCTIONS; ION CHANNEL GATING; ION CHANNELS; KIDNEY TUBULES, PROXIMAL; MECHANORECEPTORS; MECHANOTRANSDUCTION, CELLULAR; PRESSURE; STRESS, MECHANICAL;

EID: 84949570349     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00373.2015     Document Type: Review

References (37)

1. Alexander LD, Alagarsamy S, Douglas JG. Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells. Kidney Int 65: 551-563, 2004.
2. Ashworth SL, Sandoval RM, Tanner GA, Molitoris BA. Two-photon microscopy: visualization of kidney dynamics. Kidney Int 72: 416-421, 2007.
3. Bank N, Aynedjian HS, Weinstein SW. A microperfusion study of phosphate reabsorption by the rat proximal renal tubule. Effect of parathyroid hormone. J Clin Invest 54: 1040-1048, 1974.
4. Bank N, Yarger WE, Aynedjian HS. A microperfusion study of sucrose movement across the rat proximal tubule during renal vein constriction. J Clin Invest 50: 294-302, 1971.
5. Bocanegra V, Gil Lorenzo AF, Cacciamani V, Benardon ME, Costantino VV, Valles PG. RhoA and MAPK signal transduction pathways regulate NHE1-dependent proximal tubule cell apoptosis after mechanical stretch. Am J Physiol Renal Physiol 307: F881-F889, 2014.
6. Bonilha VL, Rayborn ME, Saotome I, McClatchey AI, Hollyfield JG. Microvilli defects in retinas of ezrin knockout mice. Exp Eye Res 82: 720-729, 2006.
7. Burg MB, Knepper MA. Single tubule perfusion techniques. Kidney Int 30: 166-170, 1986.
8. Christensen EI, Birn H, Storm T, Weyer K, Nielsen R. Endocytic receptors in the renal proximal tubule. Physiology (Bethesda) 27: 223- 236, 2012.
9. Corman B, Roinel N, De Rouffignac C. Water reabsorption capacity of the proximal convoluted tubule: a microperfusion study on rat kidney. J Physiol 316: 379-392, 1981.
10. Drumond MC, Deen WM. Analysis of pulsatile pressures and flows in glomerular filtration. Am J Physiol Renal Fluid Electrolyte Physiol 261: F409-F419, 1991.
11. Duan Y, Gotoh N, Yan Q, Du Z, Weinstein AM, Wang T, Weinbaum S. Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proc Natl Acad Sci USA 105: 11418-11423, 2008.
12. Essig M, Terzi F, Burtin M, Friedlander G. Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells. Am J Physiol Renal Physiol 281: F751-F762, 2001.
13. Ferrell N, Ricci KB, Groszek J, Marmerstein JT, Fissell WH. Albumin handling by renal tubular epithelial cells in a microfluidic bioreactor. Biotechnol Bioeng 109: 797-803, 2012.
14. Filipovic D, Sackin H. A calcium-permeable stretch-activated cation channel in renal proximal tubule. Am J Physiol Renal Fluid Electrolyte Physiol 260: F119-F129, 1991.
15. Frick A, Rumrich G, Ullrich KJ, Lassiter WE. Microperfusion study of calcium transport in the proximal tubule of the rat kidney. Pflügers Arch 286: 109-117, 1965.
16. Hamzeh MT, Sridhara R, Alexander LD. Cyclic stretch-induced TGF-β1 and fibronectin expression is mediated by β1-integrin through c-Src- and STAT3-dependent pathways in renal epithelial cells. Am J Physiol Renal Physiol 308: F425-F436, 2015.
17. Kang JJ, Toma I, Sipos A, McCulloch F, Peti-Peterdi J. Quantitative imaging of basic functions in renal (patho)physiology. Am J Physiol Renal Physiol 291: F495-F502, 2006.
18. Latta H, Maunsbach AB, Madden SC. Cilia in different segments of the rat nephron. J Biophys Biochem Cytol 11: 248-252, 1961.
19. Lee GM, Diguiseppi J, Gawdi GM, Herman B. Chloral hydrate disrupts mitosis by increasing intracellular free calcium. J Cell Sci 88: 603-612, 1987.
20. O'Connor AK, Malarkey EB, Berbari NF, Croyle MJ, Haycraft CJ, Bell PD, Hohenstein P, Kesterson RA, Yoder BK. An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue. Cilia 2: 8, 2013.
21. Orton DJ, Doucette AA, Maksym GN, MacLellan DL. Proteomic analysis of rat proximal tubule cells following stretch-induced apoptosis in an in vitro model of kidney obstruction. J Proteomics 100: 125-135, 2014.
22. Overgaard CE, Sanzone KM, Spiczka KS, Sheff DR, Sandra A, Yeaman C. Deciliation is associated with dramatic remodeling of epithelial cell junctions and surface domains. Mol Biol Cell 20: 102-113, 2009.
23. Peyronnet R, Martins JR, Duprat F, Demolombe S, Arhatte M, Jodar M, Tauc M, Duranton C, Paulais M, Teulon J, Honore E, Patel A. Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells. EMBO Rep 14: 1143-1148, 2013.
24. Praetorius HA. The primary cilium as sensor of fluid flow: new building blocks to the model. A review in the theme: cell signaling: proteins, pathways and mechanisms. Am J Physiol Cell Physiol 308: C198-C208, 2015.
25. Praetorius HA, Spring KR. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 184: 71-79, 2001.
26. Praetorius HA, Spring KR. The renal cell primary cilium functions as a flow sensor. Curr Opin Nephrol Hypertens 12: 517-520, 2003.
27. Quinlan MR, Docherty NG, Watson RW, Fitzpatrick JM. Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction. Am J Physiol Renal Physiol 295: F1-F11, 2008.
28. Raghavan V, Rbaibi Y, Pastor-Soler NM, Carattino MD, Weisz OA. Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci USA 111: 8506-8511, 2014.
29. Raghavan V, Weisz OA. Flow stimulated endocytosis in the proximal tubule. Curr Opin Nephrol Hypertens 24: 359-365, 2015.
30. Resnick A. Use of optical tweezers to probe epithelial mechanosensation. J Biomed Opt 15: 015005, 2010.
31. Rice WL, Van Hoek AN, Paunescu TG, Huynh C, Goetze B, Singh B, Scipioni L, Stern LA, Brown D. High resolution helium ion scanning microscopy of the rat kidney. PLoS One 8: e57051, 2013.
32. Riveline D, Zamir E, Balaban NQ, Schwarz US, Ishizaki T, Narumiya S, Kam Z, Geiger B, Bershadsky AD. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK+independent mechanism. J Cell Biol 153: 1175-1186, 2001.
33. Sackin H. Stretch-activated ion channels. Kidney Int 48: 1134-1147, 1995.
34. Sharma N, Malarkey EB, Berbari NF, O'Connor AK, Vanden Heuvel GB, Mrug M, Yoder BK. Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption. J Am Soc Nephrol 24: 456-464, 2013.
35. Tarbell JM, Ebong EE. The endothelial glycocalyx: a mechano-sensor and -transducer. Sci Signal 1: pt8, 2008.
36. Weinbaum S, Duan Y, Satlin LM, Wang T, Weinstein AM. Mechanotransduction in the renal tubule. Am J Physiol Renal Physiol 299: F1220- F1236, 2010.
37. Young B, Wheater PR. Wheater's Functional Histology: A Text and Colour Atlas. Oxford, UK: Churchill Livingstone, 2006, p. x, 437 p.