Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Kim, Eun Sung ^a   Shin, Ji Hyun ^a   Park, So Jung ^a   Jo, Yoon Kyung ^a   Kim, Jae Sung ^b   Kang, Il Hwan ^a   Nam, Jung Bum ^a   Chung, Doo Young ^a   Cho, Yoonchul ^a   Lee, EunJoo H ^a   Chang, Jong Wook ^c   Cho, Dong Hyung ^a  

^a Kyung Hee University   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Samsung Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 5; CELL PROTEIN; LC3 PROTEIN; SERTRALINE; UNCLASSIFIED DRUG; ATG5 PROTEIN, HUMAN; AUTOPHAGY RELATED PROTEIN 5; MICROTUBULE ASSOCIATED PROTEIN; SEROTONIN UPTAKE INHIBITOR; TELOMERASE;

ARTICLE; AUTOPHAGY; CELL ACTIVATION; CELL GROWTH; CILIOGENESIS; CONTROLLED STUDY; ENZYME REGULATION; EUKARYOTIC FLAGELLUM; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; RETINA PIGMENT CELL; CELL LINE; CYTOLOGY; DRUG EFFECTS; METABOLISM; RETINAL PIGMENT EPITHELIUM;

AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 5; CELL LINE; CILIA; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; RETINAL PIGMENT EPITHELIUM; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; TELOMERASE;

EID: 84923052703     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118190     Document Type: Article

References (44)

1. Davenport JR, Watts AJ, Roper VC, Croyle MJ, van Groen T, et al. (2007) Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease. Curr Biol 17: 1586-1594. PMID: 17825558
2. Cano DA, Murcia NS, Pazour GJ, Hebrok M (2004) Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131: 3457-3467. PMID: 15226261
3. Tanaka Y, Okada Y, Hirokawa N (2005) FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435: 172-177. PMID: 15889083
4. Rosenbaum JL, Witman GB (2002) Intraflagellar transport. Nat Rev Mol Cell Biol 3: 813-825. PMID: 12415299
5. Quinlan RJ, Tobin JL, Beales PL (2008) Modeling ciliopathies: Primary cilia in development and disease. Curr Top Dev Biol 84: 249-310. doi: 10.1016/S0070-2153(08)00605-4 PMID: 19186246
6. Ishikawa H, Marshall WF (2011) Ciliogenesis: building the cell's antenna. Nat Rev Mol Cell Biol 12: 222-234. doi: 10.1038/nrm3085 PMID: 21427764
7. Gerdes JM, Katsanis N (2008) Ciliary function and Wnt signal modulation. Curr Top Dev Biol 85: 175-195. doi: 10.1016/S0070-2153(08)00807-7 PMID: 19147006
8. Besschetnova TY, Kolpakova-Hart E, Guan Y, Zhou J, Olsen BR, et al. (2010) Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol 20: 182-187. doi: 10.1016/j.cub.2009.11.072 PMID: 20096584
9. Quarmby LM, Mahjoub MR (2005) Caught Nek-ing: cilia and centrioles. J Cell Sci 118: 5161-5169. PMID: 16280549
10. DiBella LM, Park A, Sun Z (2009) Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway. Hum Mol Genet 18: 595-606. doi: 10.1093/hmg/ddn384 PMID: 19008302
11. Yuan S, Li J, Diener DR, Choma MA, Rosenbaum JL, et al. (2012) Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proc Natl Acad Sci U S A 109: 2021-2026. doi: 10.1073/pnas.1112834109 PMID: 22308353
12. Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, et al. (2010) Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol 12: 1115-1122. doi: 10.1038/ncb2117 PMID: 20972424
13. Klionsky DJ, Abdalla FC, Abeliovich H, Abragam RT, Agostinis P, et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544. PMID: 22966490
14. Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, et al. (2008) Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J Cell Biol 180: 897-904. doi: 10.1083/jcb.200706028 PMID: 18332216
15. Mizushima N, Levine B, Cuervo AM, Klionsky DJ (2008) Autophagy fights disease through cellular selfdigestion. Nature 451: 1069-1075. doi: 10.1038/nature06639 PMID: 18305538
16. Kim ES, Chang H, Choi H, Shin JH, Park SJ, et al. (2014) Autophagy induced by resveratrol suppresses α-MSH-induced melanogenesis. Exp Dermatol 23: 204-206. doi: 10.1111/exd.12337 PMID: 24499351
17. Kim J, Lee JE, Heynen-Genel S, Suyama E, Ono K, et al. (2010) Functional genomic screen for modulators of ciliogenesis and cilium length. Nature 464: 1048-1051. doi: 10.1038/nature08895 PMID: 20393563
18. Joo K, Kim CG, Lee MS, Moon HY, Lee SH, et al. (2013) CCDC41 is required for ciliary vesicle docking to the mother centriole. Proc Natl Acad Sci U S A 110: 5987-5992. doi: 10.1073/pnas.1220927110 PMID: 23530209
19. Hosokawa N, Hara Y, Mizushima N (2006) Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size. FEBS Lett 580: 2623-2629. PMID: 16647067
20. Gerdes JM, Davis EE, Katsanis N (2009) The vertebrate primary cilium in development, homeostasis, and disease. Cell 137: 32-45. doi: 10.1016/j.cell.2009.03.023 PMID: 19345185
21. Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, et al. (2005) Vertebrate Smoothened functions at the primary cilium. Nature 437: 1018-1021. PMID: 16136078
22. John M Grohol (2012) "Top 25 Psychiatric Medication Prescriptions for 2011". Psych Central
23. Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, et al. (2012) Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484: 125-129. doi: 10.1038/nature10936 PMID: 22425997
24. Lee JE, Silhavy JL, Zaki MS, Schroth J, Bielas SL, et al. (2012) CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium. Nat Genet. 44: 193-199. doi: 10.1038/ng.1078 PMID: 22246503
25. Pampliega O, Orhon I, Patel B, Sridhar S, Díaz-Carretero A, et al. (2013) Functional interaction between autophagy and ciliogenesis. Nature 502: 194-200. doi: 10.1038/nature12639 PMID: 24089209
26. Jo YK, Park SJ, Shin JH, Kim Y, Hwang JJ, et al. (2011) ARP101, a selective MMP-2 inhibitor, induces autophagy-associated cell death in cancer cells. Biochem Biophys Res Commun 404: 1039-1043. doi: 10.1016/j.bbrc.2010.12.106 PMID: 21187062
27. Tang Z, Lin MG, Stowe TR, Chen S, Zhu M, et al. (2013) Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature 502: 254-257. doi: 10.1038/nature12606 PMID: 24089205
28. Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, et al. (2004) Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an (11C) DASB positron emission tomography study. Am J Psychiatry 161: 826-835. PMID: 15121647
29. Taylor D, Paton C, Shitij K (2012) The Maudsley prescribing guidelines in psychiatry. West Sussex: Wiley-Blackwell. doi: 10.1007/s12070-012-0514-9 PMID: 25621271
30. Gil-Ad I, Zolokov A, Lomnitski L, Taler M, Bar M, et al. (2008) Evaluation of the potential anti-cancer activity of the antidepressant sertraline in human colon cancer cell lines and in colorectal cancer-xenografted mice. Int J Oncol 33: 277-286. PMID: 18636148
31. Reddy KK, Lefkove B, Chen LB, Govindarajan B, Carracedo A, et al. (2008) The antidepressant sertraline downregulates Akt and has activity against melanoma cells. Pigment Cell Melanoma Res 21: 451-456. doi: 10.1111/j.1755-148X.2008.00481.x PMID: 18710373
32. Ohno Y, Hibino H, Lossin C, Inanobe A, Kurachi Y (2007) Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors. Brain Res 31: 44-51.
33. Wang GK, Mitchell J, Wang SY (2008) Block of persistent late Na+ currents by antidepressant sertraline and paroxetine. J Membr Biol 222: 79-90. doi: 10.1007/s00232-008-9103-y PMID: 18418539
34. Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, et al. (2003) Inhibition of Pglycoprotein by newer antidepressants. J Pharmacol Exp Ther 305: 197-204. PMID: 12649369
35. Daniel WA, Haduch A, Syrek M, Boksa J (2006) Direct and indirect interactions between antidepressant drugs and CYP2C6 in the rat liver during long-term treatment. Eur Neuropsychopharmacol 16: 580-587. PMID: 16503401
36. Huang CJ, Kuo DH, Chang KH, Shieh P, Chen FA, et al. (2009) Effect of the antidepressant sertraline on Ca2+ fluxes in Madin-Darby canine renal tubular cells. J Recept Signal Transduct Res 29: 342-348. doi: 10.3109/10799890903295135 PMID: 19883239
37. Chien JM, Chou CT, Pan CC, Kuo CC, Tsai JY, et al. (2011) The mechanism of sertraline-induced [Ca2+]i rise in human OC2 oral cancer cells. Hum Exp Toxicol 30: 1635-1643. doi: 10.1177/0960327110396523 PMID: 21247994
38. Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE (2013) Primary cilia are specialized calcium signalling organelles. Nature 504: 311-314. doi: 10.1038/nature12833 PMID: 24336288
39. DeCaen PG, Delling M, Vien TN, Clapham DE (2013) Direct recording and molecular identification of the calcium channel of primary cilia. Nature 504: 315-318. doi: 10.1038/nature12832 PMID: 24336289
40. Tang Z, Zhu M, Zhong Q (2014) Self-eating to remove cilia roadblock. Autophagy 10: 379-381. doi: 10.4161/auto.27346 PMID: 24343661
41. Kroemer G, Mariño G, Levine B (2010) Autophagy and the integrated stress response. Mol Cell 40: 280-293. doi: 10.1016/j.molcel.2010.09.023 PMID: 20965422
42. Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, et al. (2013) Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest 123: 5212-5230. doi: 10.1172/JCI69636 PMID: 24200693
43. Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, et al. (2007) Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell 25: 193-205. PMID: 17244528
44. Kondratskyi A, Yassine M, Kondratska K, Skryma R, Slomianny C, et al. (2013) Calcium-permeable ion channels in control of autophagy and cancer. Front Physiol 4: 272. doi: 10.3389/fphys.2013.00272 PMID: 24106480