Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH 2-terminal kinase activation

Journal of Applied Physiology

Volumn 111, Issue 5, 2011, Pages 1467-1476

  Makena, Patrudu S ^a   Gorantla, Vijay K ^a   Ghosh, Manik C ^b   Bezawada, Lavanya ^a   Balazs, Louisa ^c   Luellen, Charlean ^a   Parthasarathi, Kuashik ^b   Waters, Christopher M ^a,b   Sinclair, Scott E ^a,b  

^a Departments of Medicine Pulmonary   (United States)

^b Departments of Physiology   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Alveolar epithelium; Apoptosis; Mechanical stretch

Indexed keywords

ACETYLCYSTEINE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; CASPASE 3; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXIDIZING AGENT; POLY(ADP RIBOSE)POLYMERASE 1, MOUSE; POLY(ADP-RIBOSE)POLYMERASE-1, MOUSE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; C57BL MOUSE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; HYPEROXIA; LUNG INJURY; MALE; METABOLISM; METHODOLOGY; MITOCHONDRION; MOUSE; OXIDATIVE STRESS; TIDAL VOLUME;

ACETYLCYSTEINE; ANIMALS; ANTHRACENES; APOPTOSIS; CASPASE 3; CELL LINE; CYTOCHROMES C; EPITHELIAL CELLS; HYPEROXIA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA; OXIDANTS; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; RESPIRATION, ARTIFICIAL; TIDAL VOLUME;

EID: 81355132635     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00539.2011     Document Type: Article

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