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Volumn 27, Issue 3, 2016, Pages 217-228

Pharmacological characterization of repeated administration of the first generation abused synthetic cannabinoid CP47,497

Author keywords

CB1 receptor; dependence; designer drugs; synthetic cannabinoid; tolerance

Indexed keywords

CANNABINOID; CANNABINOID 1 RECEPTOR; CP47 497; DRONABINOL; RIMONABANT; UNCLASSIFIED DRUG; CANNABINOID RECEPTOR ANTAGONIST; ENDOCANNABINOID; GUANINE NUCLEOTIDE BINDING PROTEIN; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE;

EID: 84969776953     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/jbcpp-2015-0118     Document Type: Article
Times cited : (14)

References (60)
  • 1
    • 0014681819 scopus 로고
    • Hallucinogens of plant origin
    • Schultes RE. Hallucinogens of plant origin. Science 1969;163:245-54.
    • (1969) Science , vol.163 , pp. 245-254
    • Schultes, R.E.1
  • 4
    • 79952816579 scopus 로고    scopus 로고
    • EMCDDA European Monitoring Centre for Drugs and Drug Addiction
    • EMCDDA. European Monitoring Centre for Drugs and Drug Addiction. Thematic paper - Understanding the "Spice" phenomenon. Available at: http://www. emcdda. europa. eu/publications/ thematic-papers/spice. 2009. p. 1-34.
    • (2009) Thematic Paper - Understanding the "Spice" Phenomenon , pp. 1-34
  • 6
    • 84875635280 scopus 로고    scopus 로고
    • DNA sequence analyses of blended herbal products including synthetic cannabinoids as designer drugs
    • Ogata J, Uchiyama N, Kikura-Hanajiri R, Goda Y. DNA sequence analyses of blended herbal products including synthetic cannabinoids as designer drugs. Forensic Sci Int 2013;227:33-41.
    • (2013) Forensic Sci Int , vol.227 , pp. 33-41
    • Ogata, J.1    Uchiyama, N.2    Kikura-Hanajiri, R.3    Goda, Y.4
  • 8
    • 79953658122 scopus 로고    scopus 로고
    • CP-47, 497 seized in Wisconsin
    • The Drug Enforcement Administration
    • The Drug Enforcement Administration. CP-47, 497 seized in Wisconsin. Microgram Bull 2009;42:89-102.
    • (2009) Microgram Bull , vol.42 , pp. 89-102
  • 9
    • 0026592569 scopus 로고
    • Pharmacological profile of a series of bicyclic cannabinoid analogs: Classification as cannabimimetic agents
    • Compton DR, Johnson MR, Melvin LS, Martin BR. Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents. J Pharmacol Exp Ther 1992;260:201-9.
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 201-209
    • Compton, D.R.1    Johnson, M.R.2    Melvin, L.S.3    Martin, B.R.4
  • 12
    • 0027430992 scopus 로고
    • Structure-activity relagionships for cannabinoid receptor-binding and analgesic activity: Studies of bicyclic cannabinoid analogs
    • Melvin LS, Milne GM, Johnson MR, Subramaniam B, Wilken GH, Howlett AC. Structure-activity relagionships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs. Mol Pharmacol 1993;44:1006-15.
    • (1993) Mol Pharmacol , vol.44 , pp. 1006-1015
    • Melvin, L.S.1    Milne, G.M.2    Johnson, M.R.3    Subramaniam, B.4    Wilken, G.H.5    Howlett, A.C.6
  • 13
    • 0019947722 scopus 로고
    • Cannabimimetic activity from CP-47, 497, a derivative of 3-phenylcyclohexanol
    • Weissman A, Milne GM, Melvin LS. Cannabimimetic activity from CP-47, 497, a derivative of 3-phenylcyclohexanol. J Pharmacol Exp Ther 1982;223:516-23.
    • (1982) J Pharmacol Exp Ther , vol.223 , pp. 516-523
    • Weissman, A.1    Milne, G.M.2    Melvin, L.S.3
  • 14
    • 84865860959 scopus 로고    scopus 로고
    • Identification of synthetic cannabinoids in herbal incense blends in the United States
    • Logan BK, Reinhold LE, Xu A, Diamond FX. Identification of synthetic cannabinoids in herbal incense blends in the United States. J Forensic Sci 2012;57:1168-80.
    • (2012) J Forensic Sci , vol.57 , pp. 1168-1180
    • Logan, B.K.1    Reinhold, L.E.2    Xu, A.3    Diamond, F.X.4
  • 15
    • 79960614744 scopus 로고    scopus 로고
    • The emergence and analysis of synthetic cannabinoids
    • Hudson S, Ramsey J. The emergence and analysis of synthetic cannabinoids. Drug Test Anal 2011;3:466-78.
    • (2011) Drug Test Anal , vol.3 , pp. 466-478
    • Hudson, S.1    Ramsey, J.2
  • 16
    • 77955897603 scopus 로고    scopus 로고
    • Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in "herbal high" products
    • Hudson S, Ramsey J, King L, Timbers S, Maynard S, Dargan PI, et al. Use of high-resolution accurate mass spectrometry to detect reported and previously unreported cannabinomimetics in "herbal high" products. J Anal Toxicol 2010;34:252-60.
    • (2010) J Anal Toxicol , vol.34 , pp. 252-260
    • Hudson, S.1    Ramsey, J.2    King, L.3    Timbers, S.4    Maynard, S.5    Dargan, P.I.6
  • 18
    • 34347342722 scopus 로고    scopus 로고
    • Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    • Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, et al. Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci 2007;10:870-9.
    • (2007) Nat Neurosci , vol.10 , pp. 870-879
    • Agarwal, N.1    Pacher, P.2    Tegeder, I.3    Amaya, F.4    Constantin, C.E.5    Brenner, G.J.6
  • 19
    • 0029036140 scopus 로고
    • An examination of the central sites of action of cannabinoid-induced antinociception in the rat
    • Martin WJ, Patrick SL, Coffin P, Tsou K, Walker JM. An examination of the central sites of action of cannabinoid-induced antinociception in the rat. Life Sci 1995;56:2103-9.
    • (1995) Life Sci , vol.56 , pp. 2103-2109
    • Martin, W.J.1    Patrick, S.L.2    Coffin, P.3    Tsou, K.4    Walker, J.M.5
  • 21
    • 14644403611 scopus 로고    scopus 로고
    • Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice
    • Wiley JL, Smith FL, Razdan RK, Dewey WL. Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice. Eur J Pharmacol 2005;510:59-68.
    • (2005) Eur J Pharmacol , vol.510 , pp. 59-68
    • Wiley, J.L.1    Smith, F.L.2    Razdan, R.K.3    Dewey, W.L.4
  • 26
    • 0026969158 scopus 로고
    • Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct for delta 9-tetrahydrocannabinol
    • Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR. Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct for delta 9-tetrahydrocannabinol. J Pharmacol Exp Ther 1992;263:1118-26.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 1118-1126
    • Compton, D.R.1    Gold, L.H.2    Ward, S.J.3    Balster, R.L.4    Martin, B.R.5
  • 27
    • 33747626926 scopus 로고    scopus 로고
    • Prolonged recovery rate of CB1 receptor adaptation after cessation of long-term cannabinoid administration
    • Sim-Selley LJ, Schechter NS, Rorrer WK, Dalton GD, Hernandez J, Martin BR, et al. Prolonged recovery rate of CB1 receptor adaptation after cessation of long-term cannabinoid administration. Mol Pharmacol 2006;70:986-96.
    • (2006) Mol Pharmacol , vol.70 , pp. 986-996
    • Sim-Selley, L.J.1    Schechter, N.S.2    Rorrer, W.K.3    Dalton, G.D.4    Hernandez, J.5    Martin, B.R.6
  • 28
    • 0031793070 scopus 로고    scopus 로고
    • Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9- tetrahydrocannabinol
    • Hutcheson DM, Tzavara ET, Smadja C, Valjent E, Roques BP, Hanoune J, et al. Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9- tetrahydrocannabinol. Br J Pharmacol 1998;125:1567-77.
    • (1998) Br J Pharmacol , vol.125 , pp. 1567-1577
    • Hutcheson, D.M.1    Tzavara, E.T.2    Smadja, C.3    Valjent, E.4    Roques, B.P.5    Hanoune, J.6
  • 29
    • 84924759841 scopus 로고    scopus 로고
    • Synthetic cannabinoid withdrawal: A new demand on detoxification services
    • Macfarlane V, Christie G. Synthetic cannabinoid withdrawal: a new demand on detoxification services. Drug Alcohol Rev 2015;34:147-53.
    • (2015) Drug Alcohol Rev , vol.34 , pp. 147-153
    • Macfarlane, V.1    Christie, G.2
  • 31
    • 0016226715 scopus 로고
    • Discriminative response control produced with hashish, tetrahydrocannabinols (delta 8-THC and delta 9-THC), and other drugs
    • Järbe TU, Henriksson BG. Discriminative response control produced with hashish, tetrahydrocannabinols (delta 8-THC and delta 9-THC), and other drugs. Psychopharmacologia 1974;40: 1-16.
    • (1974) Psychopharmacologia , vol.40 , pp. 1-16
    • Järbe, T.U.1    Henriksson, B.G.2
  • 32
    • 0141451976 scopus 로고    scopus 로고
    • Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys
    • Justinova Z, Tanda G, Redhi GH, Goldberg SR. Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys. Psychopharmacology (Berl) 2003;169:135-40.
    • (2003) Psychopharmacology (Berl) , vol.169 , pp. 135-140
    • Justinova, Z.1    Tanda, G.2    Redhi, G.H.3    Goldberg, S.R.4
  • 33
    • 80051950901 scopus 로고    scopus 로고
    • Dissimilar cannabinoid substitution patterns in mice trained to discriminate (9)-tetrahydrocannabinol or methanandamide from vehicle
    • Wiley JL, Matthew Walentiny D, Vann RE, Baskfield CY. Dissimilar cannabinoid substitution patterns in mice trained to discriminate (9)-tetrahydrocannabinol or methanandamide from vehicle. Behav Pharmacol 2011;22:480-8.
    • (2011) Behav Pharmacol , vol.22 , pp. 480-488
    • Wiley, J.L.1    Matthew Walentiny, D.2    Vann, R.E.3    Baskfield, C.Y.4
  • 34
    • 0028129936 scopus 로고
    • SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
    • Rinaldi-Carmona M. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 1994;350: 240-4.
    • (1994) FEBS Lett , vol.350 , pp. 240-244
    • Rinaldi-Carmona, M.1
  • 35
    • 0033545866 scopus 로고    scopus 로고
    • Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
    • Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 1999;96:5780-5.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5780-5785
    • Zimmer, A.1    Zimmer, A.M.2    Hohmann, A.G.3    Herkenham, M.4    Bonner, T.I.5
  • 36
    • 0030593443 scopus 로고    scopus 로고
    • Cannabinoid receptor stimulation of guanosine-5-O-(3-[35S]thio)triphosphate binding in rat brain membranes
    • Selley DE, Stark S, Sim LJ, Childers SR. Cannabinoid receptor stimulation of guanosine-5-O-(3-[35S]thio)triphosphate binding in rat brain membranes. Life Sci 1996;59:659-68.
    • (1996) Life Sci , vol.59 , pp. 659-668
    • Selley, D.E.1    Stark, S.2    Sim, L.J.3    Childers, S.R.4
  • 37
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 38
    • 0038433333 scopus 로고    scopus 로고
    • Cannabinoid pharmacological properties common to other centrally acting drugs
    • Wiley J. Cannabinoid pharmacological properties common to other centrally acting drugs. Eur J Pharmacol 2003;471:185-93.
    • (2003) Eur J Pharmacol , vol.471 , pp. 185-193
    • Wiley, J.1
  • 40
    • 77953568666 scopus 로고    scopus 로고
    • FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration
    • Falenski KW, Thorpe AJ, Schlosburg JE, Cravatt BF, Abdullah RA, Smith TH, et al. FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. Neuropsychopharmacology 2010;35:1775-87.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1775-1787
    • Falenski, K.W.1    Thorpe, A.J.2    Schlosburg, J.E.3    Cravatt, B.F.4    Abdullah, R.A.5    Smith, T.H.6
  • 42
    • 0030901709 scopus 로고    scopus 로고
    • Delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain
    • Burkey TH, Quock RM, Consroe P, Roeske WR, Yamamura HI. delta 9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain. Eur J Pharmacol 1997;323:R3-4.
    • (1997) Eur J Pharmacol , vol.323 , pp. R3-4
    • Burkey, T.H.1    Quock, R.M.2    Consroe, P.3    Roeske, W.R.4    Yamamura, H.I.5
  • 43
    • 0031863268 scopus 로고    scopus 로고
    • Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes
    • Griffin G, Atkinson PJ, Showalter VM, Martin BR, Abood ME. Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes. J Pharmacol Exp Ther 1998;285:553-60.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 553-560
    • Griffin, G.1    Atkinson, P.J.2    Showalter, V.M.3    Martin, B.R.4    Abood, M.E.5
  • 44
    • 0023493916 scopus 로고
    • Structure-activity relationships of tricyclic and nonclassical bicyclic cannabinoids
    • Melvin LS, Johnson MR. Structure-activity relationships of tricyclic and nonclassical bicyclic cannabinoids. NIDA Res Monogr 1987;79:31-47.
    • (1987) NIDA Res Monogr , vol.79 , pp. 31-47
    • Melvin, L.S.1    Johnson, M.R.2
  • 45
    • 79955928510 scopus 로고    scopus 로고
    • CP47, 497-C8 and JWH073, commonly found in "Spice" herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists
    • Atwood BK, Lee D, Straiker A, Widlanski TS, Mackie K. CP47, 497-C8 and JWH073, commonly found in "Spice" herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists. Eur J Pharmacol 2011;659:139-45.
    • (2011) Eur J Pharmacol , vol.659 , pp. 139-145
    • Atwood, B.K.1    Lee, D.2    Straiker, A.3    Widlanski, T.S.4    Mackie, K.5
  • 46
    • 0021941924 scopus 로고
    • Structural requirements for cannabinoid-induced antinociceptive activity in mice
    • Martin BR. Structural requirements for cannabinoid-induced antinociceptive activity in mice. Life Sci 1985;36:1523-30.
    • (1985) Life Sci , vol.36 , pp. 1523-1530
    • Martin, B.R.1
  • 47
    • 0030423694 scopus 로고    scopus 로고
    • In vivo characterization of a specific cannabinoid receptor antagonist (SR141617A): Inhibition of delta-9-tetrahydrocannabinol-induced responses and apparent agonist activity
    • Compton DR, Aceto MD, Lowe J, Martin BR. In vivo characterization of a specific cannabinoid receptor antagonist (SR141617A): inhibition of delta-9-tetrahydrocannabinol-induced responses and apparent agonist activity. J Pharmacol Exp Ther 1996;277:586-94.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 586-594
    • Compton, D.R.1    Aceto, M.D.2    Lowe, J.3    Martin, B.R.4
  • 48
    • 35649000942 scopus 로고    scopus 로고
    • Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice
    • Monory K, Blaudzun H, Massa F, Kaiser N, Lemberger T, Schütz G, et al. Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol 2007;5:e269.
    • (2007) PLoS Biol , vol.5 , pp. e269
    • Monory, K.1    Blaudzun, H.2    Massa, F.3    Kaiser, N.4    Lemberger, T.5    Schütz, G.6
  • 49
    • 0018981254 scopus 로고
    • 3H-delta 9- Tetrahydrocannabinol, 3H-cannabinol and 3H-cannabidiol: Penetration and regional distribution in rat brain
    • Alozie SO, Martin BR, Harris LS, Dewey WL. 3H-delta 9- Tetrahydrocannabinol, 3H-cannabinol and 3H-cannabidiol: penetration and regional distribution in rat brain. Pharmacol Biochem Behav 1980;12:217-21.
    • (1980) Pharmacol Biochem Behav , vol.12 , pp. 217-221
    • Alozie, S.O.1    Martin, B.R.2    Harris, L.S.3    Dewey, W.L.4
  • 50
    • 84904287725 scopus 로고    scopus 로고
    • Development of a high-performance liquid chromatography-tandem mass spectrometry method for the identification and quantification of CP-47, 497, CP-47, 497-C8 and JWH-250 in mouse brain
    • Samano KL, Poklis JL, Lichtman AH, Poklis A. Development of a high-performance liquid chromatography-tandem mass spectrometry method for the identification and quantification of CP-47, 497, CP-47, 497-C8 and JWH-250 in mouse brain. J Anal Toxicol 2014;38:307-14.
    • (2014) J Anal Toxicol , vol.38 , pp. 307-314
    • Samano, K.L.1    Poklis, J.L.2    Lichtman, A.H.3    Poklis, A.4
  • 51
    • 84941557174 scopus 로고    scopus 로고
    • AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and potency of novel synthetic cannabinoids in producing 9-tetrahydrocannabinol-like effects in mice
    • Wiley JL, Marusich JA, Lefever TW, Antonazzo KR, Wallgren MT, Cortes RA, et al. AB-CHMINACA, AB-PINACA, and FUBIMINA: affinity and potency of novel synthetic cannabinoids in producing 9-tetrahydrocannabinol-like effects in mice. J Pharmacol Exp Ther 2015;354:328-39.
    • (2015) J Pharmacol Exp Ther , vol.354 , pp. 328-339
    • Wiley, J.L.1    Marusich, J.A.2    Lefever, T.W.3    Antonazzo, K.R.4    Wallgren, M.T.5    Cortes, R.A.6
  • 52
    • 44449118561 scopus 로고    scopus 로고
    • Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice
    • McMahon LR, Ginsburg BC, Lamb RJ. Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice. Psychopharmacology (Berl) 2008;198:487-95.
    • (2008) Psychopharmacology (Berl) , vol.198 , pp. 487-495
    • McMahon, L.R.1    Ginsburg, B.C.2    Lamb, R.J.3
  • 53
    • 84902689585 scopus 로고    scopus 로고
    • Cross-substitution of 9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats
    • Wiley JL, Lefever TW, Cortes RA, Marusich JA. Cross-substitution of 9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats. Pharmacol Biochem Behav 2014;124:123-8.
    • (2014) Pharmacol Biochem Behav , vol.124 , pp. 123-128
    • Wiley, J.L.1    Lefever, T.W.2    Cortes, R.A.3    Marusich, J.A.4
  • 54
    • 84927940122 scopus 로고    scopus 로고
    • 9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2/Spice
    • Gatch MB, Forster MJ. 9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2/Spice. Behav Pharmacol 2014;25:750-7.
    • (2014) Behav Pharmacol , vol.25 , pp. 750-757
    • Gatch, M.B.1    Forster, M.J.2
  • 55
    • 2542442555 scopus 로고    scopus 로고
    • Signaling pathways involved in the development of cannabinoid tolerance
    • Martin BR, Sim-Selley LJ, Selley DE. Signaling pathways involved in the development of cannabinoid tolerance. Trends Pharmacol Sci 2004;25:325-30.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 325-330
    • Martin, B.R.1    Sim-Selley, L.J.2    Selley, D.E.3
  • 56
    • 0031055103 scopus 로고    scopus 로고
    • Chronic treatment with a synthetic cannabinoid CP-55, 940 alters G-protein expression in the rat central nervous system
    • Rubino T, Patrini G, Parenti M, Massi P, Parolaro D. Chronic treatment with a synthetic cannabinoid CP-55, 940 alters G-protein expression in the rat central nervous system. Brain Res Mol Brain Res 1997;44:191-7.
    • (1997) Brain Res Mol Brain Res , vol.44 , pp. 191-197
    • Rubino, T.1    Patrini, G.2    Parenti, M.3    Massi, P.4    Parolaro, D.5
  • 57
    • 0033785482 scopus 로고    scopus 로고
    • Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55, 940
    • Rubino T, Viganò D, Massi P, Parolaro D. Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55, 940. J Neurochem 2000;75:2080-6.
    • (2000) J Neurochem , vol.75 , pp. 2080-2086
    • Rubino, T.1    Viganò, D.2    Massi, P.3    Parolaro, D.4


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