Spice: A never ending story?

Forensic Science International

Volumn 191, Issue 1-3, 2009, Pages 58-63

  Lindigkeit, Rainer ^a   Boehme, Anja ^a   Eiserloh, Ina ^a   Luebbecke, Maike ^a   Wiggermann, Marion ^a   Ernst, Ludger ^a   Beuerle, Till ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Alkylaminoindole; Cannabimimetic; CP 47,497 C8; GC MS; JWH 018; Spice

Indexed keywords

CANNABINOID;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CONTROL; DRUG TRAFFIC; EUROPE; GOVERNMENT REGULATION; JAPAN; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS;

EID: 69549127951     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2009.06.008     Document Type: Article

References (14)

1. Auwärter V., Dresen S., Weinmann W., Müller M., Pütz M., and Ferreirós N. Spice and other herbal blends: harmless incense or cannabinoid designer drugs?. J. Mass Spectrom. 45 (2009) 10.1002/jms.1558 (online February 2)
2. Uchiyama N., Kikura-Hanajiri R., Kawahara N., Haishima Y., and Yukihiro Goda. Identification of a cannabinoid analog as a new type of designer drug in a herbal product. Chem. Pharm. Bull. 57 (2009) 439-441
3. Bundesgestzblatt, 22. BtMÄndV, 21, January 2009.
4. Aung M.M., Griffin G., Huffman J.W., Wu M.-J., Keel C., Yang B., Showalter V.M., Abood M.E., and Martin B.R. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol. Depend. 60 (2000) 133-140
5. Huffman J.W., and Dai D. Design, synthesis and pharmacology of cannabimimetic indoles. Bioorg. Med. Chem. Lett. 4 (1994) 563-566
6. Aung M.M., Griffin G., Huffman J.W., Wu M.-J., Keel C., Yang B., Showalter V.M., Abood M.E., and Martin B.R. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug. Alcohol Depend. 60 (2000) 133-140
7. Huffman J.W., Mabon R., Wu M.-J., Lu J., Hart R., Hurst D.P., Reggio P.H., Wileyc J.L., and Martin B.R. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorg. Med. Chem. 11 (2003) 539-549
8. Huffman J.W., Szklennik P.V., Almond A., Bushell K., Selley D.E., He H., Cassidy M.I.P., Wiley J.L., and Martin B.R. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg. Med. Chem. Lett. 15 (2005) 4110-4113
9. Zhang Q., Ma P., Cole R.B., and Wang G. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal. Bioanal. Chem. 386 (2006) 1345-1355
10. Ettre L.S. Retention index expression. Chromatographia 58 (2003) 491-494
11. F. Herbert, Dune, Chilton Books, New York, 1965, Terminology of the Imperium.
12. Compton D.R., Johnson M.R., Melvin L.S., and Martin B.R. Pharmacological profile of a series of bicyclic cannabinoid analogs: classification as cannabimimetic agents. J. Pharm. Exp. Ther. 260 (1992) 201-209
13. Weissmann A., Milne G.M., and Melvin Jr. L.S. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. Pharm. Exp. Ther. 223 (1982) 516-523
14. U.S. Zimmermann, P.R. Winkelmann, M. Pilhatsch, J.A. Nees, R. Spanagel, K. Schulz, Fallbericht über körperliche Entzugszeichen und Abhängigkeitssyndrom nach chronischem Konsum von "Spice Gold", Deutsches Ärzteblatt, in press.