The pharmacological activity of inhalation exposure to marijuana smoke in mice

Drug and Alcohol Dependence

Volumn 63, Issue 2, 2001, Pages 107-116

  Lichtman, Aron H ^a   Poklis, Justin L ^a   Poklis, Alphonse ^a   Wilson, David M ^a   Martin, Billy R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

9 THC; Analgesia; Antinociception; Cannabinoid; Catalepsy; Hypothermia; Marijuana smoking; SR 141716A

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABIS; DRONABINOL; PLACEBO; RIMONABANT;

AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CATALEPSY; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; DRUG BLOOD LEVEL; EXPOSURE; HYPOTHERMIA; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOKE;

ADMINISTRATION, INHALATION; ANIMALS; AROUSAL; BODY TEMPERATURE REGULATION; CANNABINOIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MARIJUANA SMOKING; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; PAIN THRESHOLD; TETRAHYDROCANNABINOL;

EID: 0035400548     PISSN: 03768716     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0376-8716(00)00205-2     Document Type: Article

References (39)

1. Bliss C.I. Statistics in Biology. 1967;McGraw-Hill, New York.
2. 9-Tetrahydrocannabinol content and human marijuana self-administration. Psychopharmacology. 98:1989;51-55.
3. 9-tetrahydrocannabinol-induced responses and apparent agonist activity. J. Pharmacol. Exp. Ther. 277:1996;586-594.
4. Compton D.R., Rice K.C., De Costa B.R., Razdan R.K., Melvin L.S., Johnson M.R., Martin B.R. Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities. J. Pharmacol. Exp. Ther. 265:1993;218-226.
5. Cone E.T., Johnson R.E., Moore J.D., Roache J.D. Acute effects of smoking marijuana on hormones. Subjective effects and performance in male human subjects. Pharmacol. Biochem. Behav. 24:1986;1749-1754.
6. D'Amour F.E., Smith D.L. A method for determining loss of pain sensation. J. Pharm. Exp. Ther. 72:1941;74-79.
7. Devane W.A., Dysarz F.A., Johnson M.R., Melvin L.S., Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34:1988;605-613.
8. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 258:1992;1946-1949.
9. Facci L., Dal Tosa R., Romanello S., Buriani A., Skaper S., Leon A. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc. Natl. Acad. Sci. 92:1995;3376-3380.
10. Fleischman R., Hayden D., Braude M., Rosenkrantz H. Chronic marijuana inhalation toxicity in rats. Toxicol. Appl. Pharmacol. 34:1975;467-478.
11. Foltin R.W., Fischman M.W., Brady J.V., Bernstein D.J., Capriotti R.M., Nellis M.J., Kelly T.H. Motivational effects of smoked marijuana: behavioral contingencies and low-probability activities. J. Exp. Anal. Behav. 53:1990;5-19.
12. Fried P.A. Cross-tolerance between inhaled cannabis and intraperitoneal injections of delta 9-THC. Pharmacol. Biochem. Behav. 4:1976;635-638.
13. Fried P.A., Nieman G.W. Inhalation of cannabis smoke in rats. Pharmacol. Blochem. Behav. 1:1973;371-378.
14. Heishman S.J., Arasteh K., Stitzer M.L. Comparative effects of alcohol and marijuana on mood, memory, and performance. Pharmacol. Biochem. Behav. 58:1997;93-101.
15. 9-tetrahydrocannabinol reflect the degree of intoxication? J. Clin. Pharmacol. 21:1981;171S-177S.
16. Howlett A. Pharmacology of cannabinoid receptors. Annu. Rev. Pharmacol. Toxicol. 35:1995;607-634.
17. Huber G.L., Pochay V.E., Pereira W., Shea J.W., Hinds W.C., First M.W., Sornberger G.C. Marijuana, tetrahydrocannabinol, and pulmonary antibacterial defenses. Chest. 77:1980;403-410.
18. Johnston, L.D., O'Malley, P.M., Bachman, J.G., 1998. National survey results on drug use from the Monitoring the Future study, 1975-1997, vol. I: Secondary school students (NIH Publication No. 98-4345) and vol. II: College students and young adults (NIH Publication No. 98-4346). National Institute on Drug Abuse, Rockville, MD.
19. Lee M.L., Novotny M., Bartle K.D. Gas chromatography/mass spectrometric and nuclear magnetic resonance spectrometric studies of carcinogenic polynuclear aromatic hydrocarbons in tobacco and marijuana smoke condensates. Anal. Chem. 48:1976;405-416.
20. 9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. Psychopharmacology. 126:1996;125-131.
21. Lichtman A.H., Meng Y., Martin B.R. Inhalation exposure to volatilized opiates produces antinociception in mice. J. Pharmacol. Exp. Ther. 279:1996;69-76.
22. Linton P.H., Kuechenmeister C.A., White H.B., Travis R.P. Marijuana: heart rate and EEG response. Res. Commun. Chem. Pathol. Pharmacol. 10:1975;201-214.
23. Little P.J., Compton D.R., Johnson M.R., Melvin L.S., Martin B.R. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. J. Pharmacol. Exp. Ther. 247:1988;1046-1051.
24. Matsuda L. Cloning of the cannabinoid receptor gene. Neurosci. Facts. 3:1992;53.
25. Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N., Schatz A., Gopher A., Almog S., Martin B., Compton D., Pertwee R., Griffin G., Bayewitch M., Barg J., Vogel Z. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50:1995;83-90.
26. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 365:1993;61-64.
27. Ohlsson A., Lindgren J.-E., Wahlen A., Agurell S., Hollister L.E., Gillespie H.K. Plasma delta-9-tetrahydrocannabinol concentrations and effects after oral and intravenous administration and smoking. Clin. Pharmacol. Ther. 28:1980;409-416.
28. Pertwee R.G. The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice. Br. J. Pharmacol. 46:1972;753-763.
29. Razdan R.K. Structure-activity relationships in cannabinoids. Pharmacol. Rev. 38:1986;75-149.
30. Rinaldi-Carmona M., Barth F., Héaulme M., Shire D., Calandra B., Congy C., Martinez S., Maruani J., Néliat G., Caput D., Ferrara P., Soubrié P., Breliére J.C., Le Fur G. SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350:1994;240-244.
31. Rosenkrantz H., Braude M. Acute, subacute and 23-day chronic marijuana inhalation toxicities in the rat. Toxicol. Appl. Pharmacol. 28:1974;428-441.
32. Talaska G., Schamer M., Bailey J.R., Ali S.F., Scallet A.C., Slikker W.J., Paule M.G. No increase in carcinogen-DNA adducts in the lungs of monkeys exposed chronically to marijuana smoke. Toxicol. Lett. 63:1992;321-332.
33. Truitt E.B. Biological disposition of tetrahydrocannabinols. Pharm. Rev. 23:1971;273-278.
34. Truitt E.B., Kinzer G.W., Berlo J.M. Behavioral activity in various fractions of marijuana smoke condensate in the rat. Braude M.C., Szara S. The Pharmacology of Marijuana. 1976;463-474 Raven, New York.
35. 1 cannabinoid receptor in the hypotensive action of anandamide. Eur. J. Pharmacol. 278:1995;279-283.
36. Watson E.S., Jones A.B., Ashfaq M.K., Barrett J.T. Spectrophotometric evaluation of carboxyhemoglobin in blood of mice after exposure to marijuana or tobacco smoke in a modified Walton horizontal smoke exposure machine. J. Anal. Toxicol. 11:1987;19-23.
37. Weinberg A.D., Dimen E., Borzelleca J.F., Harris L.S. Weight and activity in male mice after daily inhalation of cannabis smoke in an automated smoke exposure chamber. J. Pharm. Pharmacol. 29:1977;477-481.
38. Weinberg A.D., Dimen E.M., Simon G.S., Harris L.S., Borzelleca J.F. Measurements of weight and activity in male mice following inhalation of cannabis smoke in a controlled smoke exposure chamber. Toxicol. Appl. Pharmacol. 42:1977;301-307.
39. 9-tetrahydrocannabinol in rats and rhesus monkeys. J. Pharmacol. Exp. Ther. 275:1995;1-6.