Changes in the cannabinoid receptor binding, G protein coupling, and cyclic AMP cascade in the CNS of rats tolerant to and dependent on the synthetic cannabinoid compound CP55,940

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 2080-2086

  Rubino, T ^a   Vigano, D ^a   Massi, P ^a   Parolaro, D ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Brain; Cannabinoid receptor; CP55,940; Cyclic AMP cascade; G proteins

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLOROPHENYL) 1 (2,4 DICHLOROPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID RECEPTOR; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE);

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CANNABIS ADDICTION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG TOLERANCE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; WITHDRAWAL SYNDROME;

ANIMAL; BEHAVIOR, ANIMAL; BRAIN; CANNABINOIDS; CEREBELLUM; CEREBRAL CORTEX; CORPUS STRIATUM; CYCLIC AMP; CYCLOHEXANOLS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; GTP-BINDING PROTEINS; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; MALE; MARIJUANA ABUSE; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0033785482     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752080.x     Document Type: Article

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