Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 21, 2016, Pages E3002-E3011

  Zhuo, Chen ^a   Feng, Miao ^a   Andrew, D Paterson ^b   John, M Lachin ^c   Lingxiao, Zhang ^a   Dustin, E Schones ^a   Xiwei, Wu ^a   Jinhui, Wang ^a   Joshua, D Tompkins ^a   Saul, Genuth ^d   Barbara, H Braffett ^c   Arthur, D Riggs ^a   Rama, Natarajan ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Diabetic complications; Dna methylation; Epigenetics; Metabolic memory; TXNIP

Indexed keywords

GENOMIC DNA; GLUCOSE; HEMOGLOBIN A1C; THIOREDOXIN INTERACTING PROTEIN; CARRIER PROTEIN; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; TXNIP PROTEIN, HUMAN;

ALBUMINURIA; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIABETIC RETINOPATHY; DNA METHYLATION; EPIGENETICS; GENE; GENE LOCUS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; IN VITRO STUDY; METABOLISM; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; TXNIP GENE; ADOLESCENT; ADULT; CLINICAL TRIAL; COMPARATIVE STUDY; FEMALE; GENETICS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PATHOLOGY; TUMOR CELL LINE;

ADOLESCENT; ADULT; CARRIER PROTEINS; CELL LINE, TUMOR; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; DNA METHYLATION; EPIGENOMICS; FEMALE; GENETIC LOCI; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE;

EID: 84969776770     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1603712113     Document Type: Article

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