The quantum nature of drug-receptor interactions: Deuteration changes binding affinities for histamine receptor ligands

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Kržan, Mojca ^a   Vianello, Robert ^b   Maršavelski, Aleksandra ^b   Repič, Matej ^c,d   Zakšek, Maja ^a   Kotnik, Kristina ^a   Fijan, Estera ^a   Mavri, Janez ^c  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^d KRKA D D   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLHISTAMINE; 4 METHYLHISTAMINE; DEUTERIUM OXIDE; HISTAMINE; HISTAMINE H2 RECEPTOR; HISTAMINE RECEPTOR; HYDROGEN; TIOTIDINE; TRITIUM; TYROSINE; WATER; DEUTERIUM; LIGAND;

AB INITIO CALCULATION; ANIMAL CELL; ARTICLE; ASTROCYTE CULTURE; BINDING AFFINITY; BINDING SITE; CHEMICAL MODEL; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEUTERATION; DRUG RECEPTOR BINDING; EXPERIMENTAL STUDY; HYDRATION; HYDROGEN BOND; ISOTOPE LABELING; LIGAND BINDING; MATHEMATICAL ANALYSIS; NEWBORN; NONHUMAN; PROTEIN STRUCTURE; PROTON TRANSPORT; QUANTUM CHEMISTRY; RAT; STRUCTURAL HOMOLOGY; UBBELOHDE EFFECT; ANIMAL; CHEMISTRY; METABOLISM; QUANTUM THEORY;

ANIMALS; DEUTERIUM; HISTAMINE; LIGANDS; QUANTUM THEORY; RATS; RECEPTORS, HISTAMINE;

EID: 84969760749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0154002     Document Type: Article

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