The role of PGC-1α and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells

Toxicology

Volumn 355-356, Issue , 2016, Pages 39-48

  Li, Zhen ^a   Liu, Xi ^a   Wang, Lu ^a   Wang, Yan ^b   Du, Chuang ^a   Xu, Siyuan ^c   Zhang, Yucheng ^a   Wang, Chunhong ^a   Yang, Chengfeng ^d  

^a WUHAN UNIVERSITY   (China)

^b HUBEI UNIVERSITY   (China)

^c Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Academy for Preventive Medicine   (China)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Lead acetate; Mitochondrial toxicity; MRP1; PGC 1 ; Sertoli cell

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 9; LEAD ACETATE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SIRTUIN 3; SUCCINATE DEHYDROGENASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; ORGANOMETALLIC COMPOUND; PPARGC1A PROTEIN, MOUSE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; HEAVY METAL POISONING; MALE; MITOCHONDRIAL TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SERTOLI CELL; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; METABOLISM; MITOCHONDRION; PATHOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CELL LINE; GENE KNOCKDOWN TECHNIQUES; MALE; MICE; MITOCHONDRIA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANOMETALLIC COMPOUNDS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; REACTIVE OXYGEN SPECIES; SERTOLI CELLS;

EID: 84969626603     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2016.05.016     Document Type: Article

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