Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis

Journal of Experimental Medicine

Volumn 212, Issue 12, 2015, Pages 2147-2163

  Briot, Anaïs ^a   Civelek, Mete ^a   Seki, Atsuko ^b   Hoi, Karen ^a   Mack, Julia J ^a   Lee, Stephen D ^b,c   Kim, Jason ^b,c   Hong, Cynthia ^b,c   Yu, Jingjing ^a   Fishbein, Gregory A ^b   Vakili, Ladan ^a   Fogelman, Alan M ^a   Fishbein, Michael C ^b   Lusis, Aldons J ^a   Tontonoz, Peter ^b,c   Navab, Mohamad ^a   Berliner, Judith A ^a,b   Iruela Arispe, M Luisa ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; ADRENOMEDULLIN; CHOLINE DERIVATIVE; INTERLEUKIN 1BETA; LIPID; NOTCH1 RECEPTOR; SMALL INTERFERING RNA; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; OXIDIZED-L-ALPHA-1-PALMITOYL-2-ARACHIDONOYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE; PHOSPHATIDYLCHOLINE; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ENDOTHELIUM; ARTICLE; ATHEROSCLEROSIS; CELL ACTIVATION; DISEASE PREDISPOSITION; ENDOTHELIUM CELL; FEMALE; GENETIC VARIABILITY; HEMIZYGOTE; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE; LIPID DIET; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION; VASCULITIS; ADULT; ADVERSE EFFECTS; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CONFOCAL MICROSCOPY; DNA MICROARRAY; DRUG EFFECTS; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSGENIC MOUSE; TUMOR CELL LINE;

ADULT; ANIMALS; ATHEROSCLEROSIS; CELL LINE, TUMOR; CELLS, CULTURED; DIET, HIGH-FAT; ENDOTHELIAL CELLS; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; LIPIDS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHATIDYLCHOLINES; RECEPTOR, NOTCH1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84969316154     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20150603     Document Type: Article

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