Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome

Development (Cambridge)

Volumn 139, Issue 23, 2012, Pages 4449-4460

  Hofmann, Jennifer J ^a,d   Briot, Anais ^a   Enciso, Josephine ^a   Zovein, Ann C ^a,e   Ren, Shuxun ^a   Zhang, Zhen W ^b   Radtke, Freddy ^c   Simons, Michael ^b   Wang, Yibin ^a   Luisa Iruela Arispe, M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EPFL   (Switzerland)

^d KAROLINSKA INSTITUTE   (Sweden)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aortic valves; Cardiac valves; EndMT; Mouse; Notch

Indexed keywords

JAGGED1;

ALAGILLE SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; EMBRYO; ENDOTHELIUM CELL; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VALVE; HEART VALVE CALCIFICATION; HEART VENTRICLE SEPTUM DEFECT; MALE; MOUSE; MUTANT; NONHUMAN; OVERRIDING AORTA; PRIORITY JOURNAL;

ALAGILLE SYNDROME; ANIMALS; CALCINOSIS; CALCIUM-BINDING PROTEINS; CARDIOMYOPATHIES; CORONARY VESSEL ANOMALIES; ENDOTHELIAL CELLS; ENDOTHELIUM; HEART DEFECTS, CONGENITAL; HEART SEPTAL DEFECTS, VENTRICULAR; HEART VALVE DISEASES; HYPERTROPHY, RIGHT VENTRICULAR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOGENESIS; ORGAN CULTURE TECHNIQUES; RECEPTORS, NOTCH;

MURINAE; MUS;

EID: 84868514989     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.084871     Document Type: Article

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