Discovering Echinococcus granulosus thioredoxin glutathione reductase inhibitors through site-specific dynamic combinatorial chemistry

Molecular Diversity

Volumn 18, Issue 1, 2014, Pages 1-12

  Saiz, Cecilia ^a   Castillo, Valerie ^a   Fontán, Pablo ^a   Bonilla, Mariana ^a   Salinas, Gustavo ^a   Rodríguez Haralambides, Alejandra ^b   Mahler, S Graciela ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UdelaR Pando   (Uruguay)

Author keywords

Bisthiazolidines; Drug discovery; Dynamic combinatorial chemistry; Sulfur heterodimers; Thioredoxin glutathione reductase

Indexed keywords

ANIMALS; CATALYTIC DOMAIN; COMBINATORIAL CHEMISTRY TECHNIQUES; DIMERIZATION; DRUG DISCOVERY; ECHINOCOCCUS GRANULOSUS; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; NITROBENZOATES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; THIAZOLIDINES;

EID: 84894077897     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-013-9485-3     Document Type: Article

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