A minimalistic approach to identify substrate binding features in B1 Metallo-β-lactamases

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 18, 2007, Pages 5171-5174

  Poeylaut Palena, Andrés A ^a   Tomatis, Pablo E ^b   Karsisiotis, Andreas I ^c   Damblon, Christian ^d   Mata, Ernesto G ^a   Vila, Alejandro J ^b  

^a Universidad Nacional de Rosario   (Argentina)

^b Instituto de Biologia Molecular y Celular de Rosario   (Argentina)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

Author keywords

Inhibitor design; Ligand binding; Metallo lactamases; Monocyclic lactams

Indexed keywords

AZETIDINONE DERIVATIVE; AZTREONAM; CARBAPENEM; CEPHALOSPORIN; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE BCII; PENICILLIN G; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ULTRAVIOLET SPECTROSCOPY;

BETA-LACTAMASES; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY;

EID: 34547889078     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.089     Document Type: Article

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