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Volumn 6, Issue , 2016, Pages

A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposure

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR;

EID: 84969253554     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep25975     Document Type: Article
Times cited : (26)

References (43)
  • 1
    • 84908403155 scopus 로고    scopus 로고
    • Human spaceflight: Find asteroids to get to Mars
    • Binzel, R. P. Human spaceflight: Find asteroids to get to Mars. Nature 514, 559-561 (2014).
    • (2014) Nature , vol.514 , pp. 559-561
    • Binzel, R.P.1
  • 3
    • 0346242743 scopus 로고    scopus 로고
    • The hazards of space travel
    • Setlow, R. B. The hazards of space travel. EMBO reports 4, 1013-1016 (2003).
    • (2003) EMBO Reports , vol.4 , pp. 1013-1016
    • Setlow, R.B.1
  • 4
    • 85007460924 scopus 로고    scopus 로고
    • Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: Observational study
    • Otsuka, K. et al. Intrinsic cardiovascular autonomic regulatory system of astronauts exposed long-term to microgravity in space: observational study. npj Microgravity 1, Article number: 15018 (2015).
    • (2015) Npj Microgravity , vol.1
    • Otsuka, K.1
  • 5
    • 84951264358 scopus 로고    scopus 로고
    • Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts
    • Sun, Z. et al. Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts. Sci. Rep. 5, Article number: 8077 (2015).
    • (2015) Sci. Rep. , vol.5
    • Sun, Z.1
  • 6
    • 30044447065 scopus 로고    scopus 로고
    • Genitourinary issues during spaceflight: A review
    • Jones, J. A. et al. Genitourinary issues during spaceflight: a review. Int. J. Impot. Res. 17, S64-S67 (2005).
    • (2005) Int. J. Impot. Res. , vol.17 , pp. S64-S67
    • Jones, J.A.1
  • 7
    • 0035931895 scopus 로고    scopus 로고
    • Humans in space
    • White, R. J. & Averner, M. Humans in space. Nature 409, 1115-1118 (2001).
    • (2001) Nature , vol.409 , pp. 1115-1118
    • White, R.J.1    Averner, M.2
  • 8
    • 85038012068 scopus 로고    scopus 로고
    • Alterations in adaptive immunity persist during long-duration spaceflight
    • Crucian, B. et al. Alterations in adaptive immunity persist during long-duration spaceflight. npj Microgravity 1, 15013 (2015).
    • (2015) Npj Microgravity , vol.1 , pp. 15013
    • Crucian, B.1
  • 9
    • 84903625228 scopus 로고    scopus 로고
    • Dichotomal effect of space flight-associated microgravity on stress-activated protein kinases in innate immunity
    • Verhaar, A. P. et al. Dichotomal effect of space flight-associated microgravity on stress-activated protein kinases in innate immunity. Sci. Rep. 4, 5468 (2014).
    • (2014) Sci. Rep. , vol.4 , pp. 5468
    • Verhaar, A.P.1
  • 10
    • 84908215296 scopus 로고    scopus 로고
    • T cell regulation in microgravity - The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilities
    • Hauschilda, S. et al. T cell regulation in microgravity - The current knowledge from in vitro experiments conducted in space, parabolic flights and ground-based facilities. Acta Astronaut. 104, 365-377 (2014).
    • (2014) Acta Astronaut. , vol.104 , pp. 365-377
    • Hauschilda, S.1
  • 11
    • 84947649040 scopus 로고    scopus 로고
    • The impact of microgravity and hypergravity on endothelial cells
    • Maier, J. A. M. et al. The Impact of Microgravity and Hypergravity on Endothelial Cells. Biomed. Res. Int. 2015, 434803 (2015).
    • (2015) Biomed. Res. Int. , vol.2015 , pp. 434803
    • Maier, J.A.M.1
  • 12
    • 45349083936 scopus 로고    scopus 로고
    • Transcriptional analysis of normal human fibroblast responses to microgravity stress
    • Liu, Y. & Wang, E. Transcriptional Analysis of Normal Human Fibroblast Responses to Microgravity Stress. Genomics Proteomics Bioinformatics 6, 29-41 (2008).
    • (2008) Genomics Proteomics Bioinformatics , vol.6 , pp. 29-41
    • Liu, Y.1    Wang, E.2
  • 13
    • 84942883967 scopus 로고    scopus 로고
    • Genome wide expression profiling of cancer cell lines cultured in microgravity reveals significant dysregulation of cell cycle and MicroRNA gene networks
    • 21
    • Vidyasekar, P. et al. Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks. PLoS One. 21, 10(8), e0135958 (2015).
    • (2015) PLoS One. , vol.10 , Issue.8 , pp. e0135958
    • Vidyasekar, P.1
  • 14
    • 84887038087 scopus 로고    scopus 로고
    • The challenging environment on board the international space station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: The ESA-SPHINX experiment
    • Versari, S. et al. The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment. FASEB J. 7, 4466-4475 (2013).
    • (2013) FASEB J. , vol.7 , pp. 4466-4475
    • Versari, S.1
  • 15
    • 84870448663 scopus 로고    scopus 로고
    • The Rel/NF-κ B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity
    • Chang, T. T. et al. The Rel/NF-κ B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J. Leukoc. Biol. 2012, 92, 1133-1145 (2012).
    • (2012) J. Leukoc. Biol. , vol.2012 , Issue.92 , pp. 1133-1145
    • Chang, T.T.1
  • 16
    • 84871204114 scopus 로고    scopus 로고
    • Infection prevention and control during prolonged human space travel
    • Mermel, L. A. Infection Prevention and Control During Prolonged Human Space Travel. Clin. Infect. Dis. 56, 123-130 (2013).
    • (2013) Clin. Infect. Dis. , vol.56 , pp. 123-130
    • Mermel, L.A.1
  • 17
    • 0001792966 scopus 로고
    • Clinical aspects of crew health
    • NASA Spec. Rep., Washington DC SP-368
    • Hawkins, W. R. & Ziegelschmid, J. F. Clinical aspects of crew health. Biomedical Results of Apollo. NASA Spec. Rep., Washington DC SP-368, 43-81 (1975).
    • (1975) Biomedical Results of Apollo , pp. 43-81
    • Hawkins, W.R.1    Ziegelschmid, J.F.2
  • 18
    • 84904102940 scopus 로고    scopus 로고
    • Integration analysis of microRNA and mRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity
    • Girardi, C. et al. Integration analysis of microRNA and mRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity. Biomed. Res. Int. 2014, 296747 (2014).
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 296747
    • Girardi, C.1
  • 19
    • 80052783075 scopus 로고    scopus 로고
    • Effects of simulated microgravity on expression profile of MicroRNA in human lymphoblastoid cells
    • Mangala, L. S. et al. Effects of Simulated Microgravity on Expression Profile of MicroRNA in Human Lymphoblastoid Cells. J. Biol. Chem. 286, 32483-32490 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 32483-32490
    • Mangala, L.S.1
  • 20
    • 33750545620 scopus 로고    scopus 로고
    • Gene expression alterations in activated human t-cells induced by modeled microgravity
    • Ward, N. E. et al. Gene Expression Alterations in Activated Human T-Cells Induced by Modeled Microgravity. J. Cell. Biochem. 99, 1187-1202 (2006).
    • (2006) J. Cell. Biochem. , vol.99 , pp. 1187-1202
    • Ward, N.E.1
  • 21
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian, A. et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102, 15545-15550 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15545-15550
    • Subramanian, A.1
  • 22
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti, M. E. et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. USA 100, 8466-8471 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8466-8471
    • Patti, M.E.1
  • 23
    • 3242813597 scopus 로고    scopus 로고
    • Differential gene expression in ovarian carcinoma: Identification of potential biomarkers
    • Hibbs, K. et al. Differential Gene Expression in Ovarian Carcinoma: Identification of Potential Biomarkers. Am. J. Pathol. 165, 397-414 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 397-414
    • Hibbs, K.1
  • 24
    • 84920578473 scopus 로고    scopus 로고
    • Identification of biomarkers in breast cancer by gene expression profiling using human tissues
    • Fu, J. et al. Identification of biomarkers in breast cancer by gene expression profiling using human tissues. Genom. Data. 2, 299-301 (2014).
    • (2014) Genom. Data. , vol.2 , pp. 299-301
    • Fu, J.1
  • 25
    • 0033592606 scopus 로고    scopus 로고
    • Learning the parts of objects by non-negative matrix factorization
    • Lee, D. D. & Seung, H. S. Learning the parts of objects by non-negative matrix factorization. Nature 401, 788-791 (1999).
    • (1999) Nature , vol.401 , pp. 788-791
    • Lee, D.D.1    Seung, H.S.2
  • 26
    • 1642529511 scopus 로고    scopus 로고
    • Metagenes and molecular pattern discovery using matrix factorization
    • Brunet, J. P. et al. Metagenes and molecular pattern discovery using matrix factorization. Proc. Natl. Acad. Sci. USA 101, 4164-4169 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4164-4169
    • Brunet, J.P.1
  • 27
    • 48249151183 scopus 로고    scopus 로고
    • Nonnegative matrix factorization: An analytical and interpretive tool in computational biology
    • Devarajan, K. Nonnegative Matrix Factorization: An Analytical and Interpretive Tool in Computational Biology. PLoS Comput. Biol. 47, e1000029 (2008).
    • (2008) PLoS Comput. Biol. , vol.47 , pp. e1000029
    • Devarajan, K.1
  • 28
    • 0037810449 scopus 로고    scopus 로고
    • Subsystem identification through dimensionality reduction of large-scale gene expression data
    • Kim, P. & Tidor, B. Subsystem identification through dimensionality reduction of large-scale gene expression data. Genome Res. 13, 1706-1718 (2003).
    • (2003) Genome Res. , vol.13 , pp. 1706-1718
    • Kim, P.1    Tidor, B.2
  • 29
    • 84876515907 scopus 로고    scopus 로고
    • STRING v9.1: Protein-protein interaction networks, with increased coverage and integration
    • Franceschini, A. et al. STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucl. Acids Res. 41, D808-D815 (2013).
    • (2013) Nucl. Acids Res. , vol.41 , pp. D808-D815
    • Franceschini, A.1
  • 30
    • 70349249979 scopus 로고    scopus 로고
    • Notch1 upregulates LPS-induced macrophage activation by increasing NF-jB activity
    • Monsalve, E. et al. Notch1 upregulates LPS-induced macrophage activation by increasing NF-jB activity. Eur. J. Immunol. 39, 2556-2570 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 2556-2570
    • Monsalve, E.1
  • 31
    • 84865189146 scopus 로고    scopus 로고
    • NFAT control of innate immunity
    • Fric, J. et al. NFAT control of innate immunity. Blood 120, 1380-1389 (2012).
    • (2012) Blood , vol.120 , pp. 1380-1389
    • Fric, J.1
  • 32
    • 84858976269 scopus 로고    scopus 로고
    • 2+ mobilization and nuclear factor of activated T cells (NFAT) activation
    • 2+ mobilization and nuclear factor of activated T cells (NFAT) activation. J. Biol. Chem. 287, 10200-10209 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 10200-10209
    • Kliem, C.1
  • 33
    • 84899746859 scopus 로고    scopus 로고
    • Space radiation risks for astronauts on multiple international space station missions
    • Cucinotta, F. A. Space Radiation Risks for Astronauts on Multiple International Space Station Missions. PLoS ONE 9(4), e96099 (2014).
    • (2014) PLoS ONE , vol.9 , Issue.4 , pp. e96099
    • Cucinotta, F.A.1
  • 34
    • 33846903838 scopus 로고    scopus 로고
    • Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease
    • O'Sullivan, L. A. et al. Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. Mol. Immunol. 44, 2497-2506 (2007).
    • (2007) Mol. Immunol. , vol.44 , pp. 2497-2506
    • O'Sullivan, L.A.1
  • 35
    • 84901752701 scopus 로고    scopus 로고
    • Mitochondrial dysfunctions in neurodegenerative diseases: Relevance to Alzheimer's disease
    • Hroudová, J. et al. Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer's Disease. BioMed. Res. Int. 2014, 175062 (2014).
    • (2014) BioMed. Res. Int. , vol.2014 , pp. 175062
    • Hroudová, J.1
  • 36
    • 84939864925 scopus 로고    scopus 로고
    • 2015 mitochondrial and ubiquitin proteasome system dysfunction in ageing and disease: Two sides of the same coin?
    • Ross, J. M. et al. 2015 Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin? Int. J. Mol. Sci. 16, 19458-19476 (2015).
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 19458-19476
    • Ross, J.M.1
  • 37
    • 0028539762 scopus 로고
    • Fluid dynamics within rotating bioreactor in space and earth environment
    • Tsao, Y. M. D. et al. Fluid dynamics within rotating bioreactor in space and earth environment. J. spacecrafts rockets. 31, 937-945 (1994).
    • (1994) J. Spacecrafts Rockets. , vol.31 , pp. 937-945
    • Tsao, Y.M.D.1
  • 38
    • 2942532125 scopus 로고    scopus 로고
    • Microbial responses to microgravity and other low-shear environments
    • Nickerson, C. A. et al. Microbial Responses to Microgravity and Other Low-Shear Environments. Microbiol Mol Biol Rev. 68, 345-361 (2004).
    • (2004) Microbiol Mol Biol Rev. , vol.68 , pp. 345-361
    • Nickerson, C.A.1
  • 39
    • 0027462466 scopus 로고
    • Flow-related responses of intracellular inositol phosphate levels in cultured aortic endothelial cells
    • Prasad, A. R. S. et al. Flow-Related Responses of Intracellular Inositol Phosphate Levels in Cultured Aortic Endothelial Cells. Circ. Res. 72, 827-836 (1993).
    • (1993) Circ. Res. , vol.72 , pp. 827-836
    • Prasad, A.R.S.1
  • 40
    • 0030891305 scopus 로고    scopus 로고
    • A mathematical model of the cytosolic-free calcium response in endothelial cells to fluid shear stress
    • Wiesner, T. et al. A mathematical model of the cytosolic-free calcium response in endothelial cells to fluid shear stress. Proc. Natl. Acad. Sci. USA 94, 3726-3731 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3726-3731
    • Wiesner, T.1
  • 41
    • 84923681930 scopus 로고    scopus 로고
    • JAK-STAT and bone metabolism
    • Licorresponding, J. JAK-STAT and bone metabolism. JAKSTAT. 2, e23930 (2013).
    • (2013) JAKSTAT , vol.2 , pp. e23930
    • Licorresponding, J.1
  • 42
    • 84876798249 scopus 로고    scopus 로고
    • An update to space biomedical research: Tissue engineering in microgravity bioreactor
    • Barzegari, A. & Saei, A. A. An update to space biomedical research: Tissue engineering in microgravity bioreactor. Bioimpacts. 2, 23-32 (2012).
    • (2012) Bioimpacts , vol.2 , pp. 23-32
    • Barzegari, A.1    Saei, A.A.2
  • 43
    • 0035983877 scopus 로고    scopus 로고
    • The effect of microgravity and space flight on the chemical senses
    • Olabi, A. A. et al. The effect of microgravity and space flight on the chemical senses. J. Food Sci. 67, 468-478 (2002).
    • (2002) J. Food Sci. , vol.67 , pp. 468-478
    • Olabi, A.A.1


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