Attenuation of β-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity

Journal of Neuroscience

Volumn 36, Issue 2, 2016, Pages 632-641

  Yuan, Peng ^a   Grutzendler, Jaime ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer s disease; Amyloid plaque; Axonal dystrophy; DREADD; Neural activity

Indexed keywords

AMYLOID BETA PROTEIN; DESIGNER DRUG; PARVOVIRUS VECTOR; (E,E)-1-FLUORO-2,5-BIS-(3-HYDROXYCARBONYL-4-HYDROXY)STYRYLBENZENE; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; AMYLOID PRECURSOR PROTEIN; CALCIUM BINDING PROTEIN; CLOZAPINE; CLOZAPINE N-OXIDE; INSULINASE; LAMP1 PROTEIN, MOUSE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; NERVE PROTEIN; PRESENILIN 1; PROTEIN C FOS; PSEN1 PROTEIN, HUMAN; STYRENE DERIVATIVE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CONDUCTION; NEUROMODULATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPSE; ANALOGS AND DERIVATIVES; ANIMAL; DISEASE MODEL; GENETIC TRANSDUCTION; GENETICS; HUMAN; METABOLISM; NEUROTOXICITY SYNDROMES; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CALCIUM-BINDING PROTEINS; CLOZAPINE; DESIGNER DRUGS; DISEASE MODELS, ANIMAL; HUMANS; INSULYSIN; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MALE; MICE; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; NERVE TISSUE PROTEINS; NEUROTOXICITY SYNDROMES; PRESENILIN-1; PROTO-ONCOGENE PROTEINS C-FOS; STYRENES; TRANSDUCTION, GENETIC;

EID: 84954326524     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2531-15.2016     Document Type: Article

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