Knockdown of hypoxia inducible factor-2α inhibits cell invasion via the downregulation of MMP-2 expression in breast cancer cells

Oncology Letters

Volumn 11, Issue 6, 2016, Pages 3743-3748

  Li, Na ^a   Wang, Hongxing ^a   Zhang, Jie ^a   Zhao, Erchen ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; HIF 2 ; Invasion; MMP 2; SiRNA

Indexed keywords

GELATINASE A; HYPOXIA INDUCIBLE FACTOR 2ALPHA;

ARTICLE; BREAST CANCER; CANCER GROWTH; CELL INVASION; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HYPOXIA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

EID: 84966746437     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2016.4471     Document Type: Article

References (36)

1. Bohensky J, Terkhorn SP, Freeman TA, Adams CS, Garcia JA, Shapiro IM and Srinivas V: Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum 60: 1406-1415, 2009.
2. Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J and Ratcliffe PJ: Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem 284: 16767-16775, 2009.
3. Kütscher C, Lampert FM, Kunze M, Markfeld-Erol F, Stark GB and Finkenzeller G: Overexpression of hypoxia-inducible factor-1 alpha improves vasculogenesis-related functions of endothelial progenitor cells. Microvasc Res 105: 85-92, 2016.
4. Rankin EB, Rha J, Unger TL, Wu CH, Shutt HP, Johnson RS, Simon MC, Keith B and Haase VH: Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene 27: 5354-5358, 2008.
5. Copple BL, Bai S and Moon JO: Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells. Hepatol Res 40: 530-539, 2010.
6. Wykoff CC, Sotiriou C, Cockman ME, Ratcliffe PJ, Maxwell P, Liu E and Harris AL: Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. Br J Cancer 90: 1235-1243, 2004.
7. Liu W, Xin H, Eckert DT, Brown JA and Gnarra JR: Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor. Oncogene 30: 21-31, 2011.
8. Zhao S, Jin C, Zhao X, Jin B, Hui L, Zhou W, Niu G and Tao S: Expression and clinical significance of ING4 and HIF-1 alpha in brain astrocytoma. Zhonghua Yi Xue Za Zhi 95: 3533-3536, 2015 (In Chinese).
9. Burrows N, Babur M, Resch J, Williams KJ and Brabant G: Hypoxia-inducible factor in thyroid carcinoma. J Thyroid Res 2011: 762905, 2011.
10. Trisciuoglio D, Gabellini C, Desideri M, Ziparo E, Zupi G and Del Bufalo D: Bcl-2 regulates HIF-1α protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. PLoS One 5: e11772, 2010.
11. Mardilovich K and and Shaw LM: Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion. Cancer Res 69: 8894-8901, 2009. 10.1158/0008-5472.CAN-09-1152.
12. Raval RR, Lau KW, Tran MGB, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL and Ratcliffe PJ: Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25: 5675-5686, 2005.
13. Mazumdar J, Hickey MM, Pant DK, Durham AC, Sweet-Cordero A, Vachani A, Jacks T, Chodosh LA, Kissil JL, Simon MC and Keith B: HIF-2α deletion promotes Kras-driven lung tumor development. Proc Natl Acad Sci USA 107: 14182-14187, 2010.
14. Florczyk U, Czauderna S, Stachurska A, Tertil M, Nowak W, Kozakowska M, Poellinger L, Jozkowicz A, Loboda A and Dulak J: Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells. Free Radic Biol Med 1: 1882-1892, 2011.
15. Rankin EB, Rha J, Selak MA, Unger TL, Keith B, Liu Q and Haase VH: Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol Cell Biol 29: 4527-4538, 2009.
16. Choi YK, Kim CK, Lee H, Jeoung D, Ha KS, Kwon YG, Kim KW and Kim YM: Carbon monoxide promotes VEGF expression by increasing HIF-1α protein level via two distinct mechanisms, translational activation and stabilization of HIF-1α protein. J Biol Chem 285: 32116-32125, 2010.
17. Kapitsinou PP, Liu Q, Unger TL, Rha J, Davidoff O, Keith B, Epstein JA, Moores SL, Erickson-Miller CL and Haase VH: Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood 116: 3039-3048, 2010.
18. Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B and Haase VH: Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest 117: 1068-1077, 2007.
19. Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, et al: A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med 19: 1331-1337, 2013.
20. Qiu Y, Zheng H, Sun LH, Peng K, Xiao WD and Yang H: Hypoxia-inducible factor-1 modulates upregulation of mutT homolog-1 in colorectal cancer. World J Gastroenterol 21: 13447-13456, 2015.
21. Fukasawa T, Enomoto A and Miyagawa K: Serine-Threonine Kinase 38 regulates CDC25A stability and the DNA damage-induced G2/M checkpoint. Cell Signal 27: 1569-1575, 2015.
22. Meade ES, Ma YY and Guller S: Role of hypoxia-inducible transcription factors 1α and 2α in the regulation of plasminogen activator inhibitor-1 expression in a human trophoblast cell line. Placenta 28: 1012-1019, 2007.
23. Li N, Wang HX, Zhang A, Ye YP and He GY: KISS-1 inhibits the proliferation and invasion of gastric carcinoma cells. World J Gastroenterol 18: 1827-1833, 2012.
24. Semenza GL: Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29: 625-634, 2010.
25. Bensellam M, Duvillié B, Rybachuk G, Laybutt DR, Magnan C, Guiot Y, Pouysségur J and Jonas JC: Glucose-induced O2 consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells. PLoS One 7: e29807, 2012.
26. Jing SW, Wang YD, Kuroda M, Su JW, Sun GG, Liu Q, Cheng YJ and Yang CR: HIF-1α contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression. Acta Med Okayama 66: 399-407, 2012.
27. Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT and McLoughlin P: Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung. Am J Respir Crit Care Med 178: 977-983, 2008.
28. Gordan JD, Bertout JA, Hu CJ, Diehl JA and Simon MC: HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 11: 335-347, 2007.
29. Huang KT, Takano EA, Mikeska T, Byrne DJ, Dobrovic A and Fox SB: Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer. Breast Cancer Res Treat 130: 319-329, 2011.
30. Li N, Wang HX, Qin C, Wang XH and Han FY: Relationship between clinicopathological features and HIF-2α in gastric adenocarcinoma. Genet Mol Res 14:1404-1413, 2015.
31. Xiao H, Gu Z, Wang G and Zhao T: The possible mechanisms underlying the impairment of HIF-1α pathway signaling in hyperglycemia and the beneficial effects of certain therapies. Int J Med Sci 10: 1412-1421, 2013.
32. Yokoe S, Nakagawa T, Kojima Y, Higuchi K and Asahi M: Indomethacin-induced intestinal epithelial cell damage is mediated by pVHL activation through the degradation of collagen I and HIF-1α. Biochem Biophys Res Commun 468: 671-676, 2015.
33. Zhu P, Ning Y, Yao L, Chen M and Xu C: The proliferation, apoptosis, invasion of endothelial-like epithelial ovarian cancer cells induced by hypoxia. J Exp Clin Cancer Res 29: 124, 2010.
34. Yoo HI, Moon YH and Kim MS: Effects of CoCl2 on multi-lineage differentiation of C3H/10T1/2 mesenchymal stem cells. Korean J Physiol Pharmacol 20:53-62, 2016.
35. Wang Q, Peng K and He L: Expression of the HIF-2α in epithelial ovarian cancer and clinical significance. Zhong Nan Da Xue Xue Bao Yi Xue Ban 39:889-893, 2014.
36. Anelli V, Gault CR, Cheng AB and Obeid LM: Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J Biol Chem 283: 3365-3375, 2008.