Indomethacin-induced intestinal epithelial cell damage is mediated by pVHL activation through the degradation of collagen i and HIF-1α

Biochemical and Biophysical Research Communications

Volumn 468, Issue 4, 2015, Pages 671-676

  Yokoe, Shunichi ^a   Nakagawa, Takatoshi ^a   Kojima, Yuichi ^a   Higuchi, Kazuhide ^a   Asahi, Michio ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Collagen I; HIF 1 ; Indomethacin; Intestinal epithelial cell damage; pVHL

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; COLLAGEN TYPE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDOMETACIN; MANGANESE SUPEROXIDE DISMUTASE; PROLYL HYDROXYLASE INHIBITOR; SMALL INTERFERING RNA; VON HIPPEL LINDAU PROTEIN; CARRIER PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; VBP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DOWN REGULATION; IMMUNOPRECIPITATION; IN VIVO STUDY; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; UBIQUITINATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; INTESTINE MUCOSA; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRIER PROTEINS; CELL LINE; CELL SURVIVAL; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOMETHACIN; INTESTINAL MUCOSA; MICE;

EID: 84949626375     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.11.014     Document Type: Article

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