메뉴 건너뛰기




Volumn 15, Issue 8, 2016, Pages 1660-1672

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

Author keywords

Autophagy; Invasion; LC3; Metastasis; Paxillin

Indexed keywords

CELL MARKER; PAXILLIN; PROTEIN LC3; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; AUTOPHAGY RELATED PROTEIN; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN BINDING;

EID: 84966667399     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.04.065     Document Type: Article
Times cited : (260)

References (55)
  • 2
    • 33845597048 scopus 로고    scopus 로고
    • Serine phosphorylation regulates paxillin turnover during cell migration
    • Abou Zeid N., Vallés A.-M., Boyer B. Serine phosphorylation regulates paxillin turnover during cell migration. Cell Commun. Signal. 2006, 4:8.
    • (2006) Cell Commun. Signal. , vol.4 , pp. 8
    • Abou Zeid, N.1    Vallés, A.-M.2    Boyer, B.3
  • 4
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson C.J., Miller F.R. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res. 1992, 52:1399-1405.
    • (1992) Cancer Res. , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 5
    • 84883414890 scopus 로고    scopus 로고
    • The LIR motif - crucial for selective autophagy
    • Birgisdottir A.B., Lamark T., Johansen T. The LIR motif - crucial for selective autophagy. J. Cell Sci. 2013, 126:3237-3247.
    • (2013) J. Cell Sci. , vol.126 , pp. 3237-3247
    • Birgisdottir, A.B.1    Lamark, T.2    Johansen, T.3
  • 6
    • 33845764296 scopus 로고    scopus 로고
    • A guided tour into subcellular colocalization analysis in light microscopy
    • Bolte S., Cordelières F.P. A guided tour into subcellular colocalization analysis in light microscopy. J. Microsc. 2006, 224:213-232.
    • (2006) J. Microsc. , vol.224 , pp. 213-232
    • Bolte, S.1    Cordelières, F.P.2
  • 9
    • 38049073134 scopus 로고    scopus 로고
    • Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation
    • Chen G.C., Lee J.Y., Tang H.W., Debnath J., Thomas S.M., Settleman J. Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy 2008, 4:37-45.
    • (2008) Autophagy , vol.4 , pp. 37-45
    • Chen, G.C.1    Lee, J.Y.2    Tang, H.W.3    Debnath, J.4    Thomas, S.M.5    Settleman, J.6
  • 10
    • 50249107474 scopus 로고    scopus 로고
    • Paxillin comes of age
    • Deakin N.O., Turner C.E. Paxillin comes of age. J. Cell Sci. 2008, 121:2435-2444.
    • (2008) J. Cell Sci. , vol.121 , pp. 2435-2444
    • Deakin, N.O.1    Turner, C.E.2
  • 13
    • 0032472411 scopus 로고    scopus 로고
    • The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
    • Fincham V.J., Frame M.C. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 1998, 17:81-92.
    • (1998) EMBO J. , vol.17 , pp. 81-92
    • Fincham, V.J.1    Frame, M.C.2
  • 14
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • Fung C., Lock R., Gao S., Salas E., Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol. Biol. Cell 2008, 19:797-806.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 20
    • 0036142219 scopus 로고    scopus 로고
    • The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
    • Hagel M., George E.L., Kim A., Tamimi R., Opitz S.L., Turner C.E., Imamoto A., Thomas S.M. The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol. Cell. Biol. 2002, 22:901-915.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 901-915
    • Hagel, M.1    George, E.L.2    Kim, A.3    Tamimi, R.4    Opitz, S.L.5    Turner, C.E.6    Imamoto, A.7    Thomas, S.M.8
  • 21
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
    • Hara T., Takamura A., Kishi C., Iemura S., Natsume T., Guan J.L., Mizushima N. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J. Cell Biol. 2008, 181:497-510.
    • (2008) J. Cell Biol. , vol.181 , pp. 497-510
    • Hara, T.1    Takamura, A.2    Kishi, C.3    Iemura, S.4    Natsume, T.5    Guan, J.L.6    Mizushima, N.7
  • 26
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • Kimmelman A.C. The dynamic nature of autophagy in cancer. Genes Dev. 2011, 25:1999-2010.
    • (2011) Genes Dev. , vol.25 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 28
    • 60549093730 scopus 로고    scopus 로고
    • Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
    • Korolchuk V.I., Mansilla A., Menzies F.M., Rubinsztein D.C. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol. Cell 2009, 33:517-527.
    • (2009) Mol. Cell , vol.33 , pp. 517-527
    • Korolchuk, V.I.1    Mansilla, A.2    Menzies, F.M.3    Rubinsztein, D.C.4
  • 29
    • 78649338141 scopus 로고    scopus 로고
    • Autophagy and the integrated stress response
    • Kroemer G., Mariño G., Levine B. Autophagy and the integrated stress response. Mol. Cell 2010, 40:280-293.
    • (2010) Mol. Cell , vol.40 , pp. 280-293
    • Kroemer, G.1    Mariño, G.2    Levine, B.3
  • 31
    • 0035954424 scopus 로고    scopus 로고
    • Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells
    • Laukaitis C.M., Webb D.J., Donais K., Horwitz A.F. Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells. J. Cell Biol. 2001, 153:1427-1440.
    • (2001) J. Cell Biol. , vol.153 , pp. 1427-1440
    • Laukaitis, C.M.1    Webb, D.J.2    Donais, K.3    Horwitz, A.F.4
  • 32
    • 84856003912 scopus 로고    scopus 로고
    • Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    • Lazova R., Camp R.L., Klump V., Siddiqui S.F., Amaravadi R.K., Pawelek J.M. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin. Cancer Res. 2012, 18:370-379.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 370-379
    • Lazova, R.1    Camp, R.L.2    Klump, V.3    Siddiqui, S.F.4    Amaravadi, R.K.5    Pawelek, J.M.6
  • 33
    • 84862789618 scopus 로고    scopus 로고
    • Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
    • Liu L., Feng D., Chen G., Chen M., Zheng Q., Song P., Ma Q., Zhu C., Wang R., Qi W., et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 2012, 14:177-185.
    • (2012) Nat. Cell Biol. , vol.14 , pp. 177-185
    • Liu, L.1    Feng, D.2    Chen, G.3    Chen, M.4    Zheng, Q.5    Song, P.6    Ma, Q.7    Zhu, C.8    Wang, R.9    Qi, W.10
  • 34
    • 84897946801 scopus 로고    scopus 로고
    • Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion
    • Lock R., Kenific C.M., Leidal A.M., Salas E., Debnath J. Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discov. 2014, 4:466-479.
    • (2014) Cancer Discov. , vol.4 , pp. 466-479
    • Lock, R.1    Kenific, C.M.2    Leidal, A.M.3    Salas, E.4    Debnath, J.5
  • 35
    • 57449121645 scopus 로고    scopus 로고
    • The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
    • Lu Z., Luo R.Z., Lu Y., Zhang X., Yu Q., Khare S., Kondo S., Kondo Y., Yu Y., Mills G.B., et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J. Clin. Invest. 2008, 118:3917-3929.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3917-3929
    • Lu, Z.1    Luo, R.Z.2    Lu, Y.3    Zhang, X.4    Yu, Q.5    Khare, S.6    Kondo, S.7    Kondo, Y.8    Yu, Y.9    Mills, G.B.10
  • 38
    • 81055144784 scopus 로고    scopus 로고
    • Autophagy: renovation of cells and tissues
    • Mizushima N., Komatsu M. Autophagy: renovation of cells and tissues. Cell 2011, 147:728-741.
    • (2011) Cell , vol.147 , pp. 728-741
    • Mizushima, N.1    Komatsu, M.2
  • 39
    • 77956064817 scopus 로고    scopus 로고
    • Cell adhesion: integrating cytoskeletal dynamics and cellular tension
    • Parsons J.T., Horwitz A.R., Schwartz M.A. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat. Rev. Mol. Cell Biol. 2010, 11:633-643.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 633-643
    • Parsons, J.T.1    Horwitz, A.R.2    Schwartz, M.A.3
  • 43
    • 79959677602 scopus 로고    scopus 로고
    • Life at the leading edge
    • Ridley A.J. Life at the leading edge. Cell 2011, 145:1012-1022.
    • (2011) Cell , vol.145 , pp. 1012-1022
    • Ridley, A.J.1
  • 44
    • 84892859905 scopus 로고    scopus 로고
    • Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy
    • Rogov V., Dötsch V., Johansen T., Kirkin V. Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy. Mol. Cell 2014, 53:167-178.
    • (2014) Mol. Cell , vol.53 , pp. 167-178
    • Rogov, V.1    Dötsch, V.2    Johansen, T.3    Kirkin, V.4
  • 48
    • 0035890917 scopus 로고    scopus 로고
    • Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin
    • Schaller M.D., Schaefer E.M. Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin. Biochem. J. 2001, 360:57-66.
    • (2001) Biochem. J. , vol.360 , pp. 57-66
    • Schaller, M.D.1    Schaefer, E.M.2
  • 49
    • 84885600527 scopus 로고    scopus 로고
    • Inhibiting autophagy by shRNA knockdown: cautions and recommendations
    • Staskiewicz L., Thorburn J., Morgan M.J., Thorburn A. Inhibiting autophagy by shRNA knockdown: cautions and recommendations. Autophagy 2013, 9:1449-1450.
    • (2013) Autophagy , vol.9 , pp. 1449-1450
    • Staskiewicz, L.1    Thorburn, J.2    Morgan, M.J.3    Thorburn, A.4
  • 51
    • 0036222784 scopus 로고    scopus 로고
    • Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again
    • Webb D.J., Parsons J.T., Horwitz A.F. Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again. Nat. Cell Biol. 2002, 4:E97-E100.
    • (2002) Nat. Cell Biol. , vol.4 , pp. E97-E100
    • Webb, D.J.1    Parsons, J.T.2    Horwitz, A.F.3
  • 54
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 2012, 12:401-410.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 55
    • 0344465841 scopus 로고    scopus 로고
    • Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells
    • Zaidel-Bar R., Ballestrem C., Kam Z., Geiger B. Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. J. Cell Sci. 2003, 116:4605-4613.
    • (2003) J. Cell Sci. , vol.116 , pp. 4605-4613
    • Zaidel-Bar, R.1    Ballestrem, C.2    Kam, Z.3    Geiger, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.