Ornithine and Homocitrulline Impair Mitochondrial Function, Decrease Antioxidant Defenses and Induce Cell Death in Menadione-Stressed Rat Cortical Astrocytes: Potential Mechanisms of Neurological Dysfunction in HHH Syndrome

Neurochemical Research

Volumn 41, Issue 9, 2016, Pages 2190-2198

  Zanatta, Ângela ^a   Rodrigues, Marília Danyelle Nunes ^a   Amaral, Alexandre Umpierrez ^a   Souza, Débora Guerini ^a   Quincozes Santos, André ^a   Wajner, Moacir ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Astrocytes; HHH syndrome; Homocitrulline; Mitochondrial function; Ornithine; Oxidative stress

Indexed keywords

GLUTATHIONE; HOMOCITRULLINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MENADIONE; ORNITHINE; PROPIDIUM IODIDE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; AMINO ACID TRANSPORTER; ANTIOXIDANT; CITRULLINE; ORNITHINE TRANSPORTER; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CELL DEATH; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; HYPERORNITHINEMIA HYPERAMMONEMIA HOMOCITRULLINURIA SYNDROME; INFLAMMATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; NERVE CELL STIMULATION; NEUROLOGIC DISEASE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; ANALOGS AND DERIVATIVES; ANIMAL; DEFICIENCY; DRUG EFFECT; HYPERAMMONEMIA; METABOLISM; MITOCHONDRION; UREA CYCLE DISORDER; WISTAR RAT;

AMINO ACID TRANSPORT SYSTEMS, BASIC; ANIMALS; ANTIOXIDANTS; ASTROCYTES; CELL DEATH; CITRULLINE; HYPERAMMONEMIA; MALE; MITOCHONDRIA; ORNITHINE; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA; UREA CYCLE DISORDERS, INBORN;

EID: 84966602568     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-016-1933-x     Document Type: Article

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