Comparing the effects of two neurotoxins in cortical astrocytes obtained from rats of different ages: Involvement of oxidative damage

Journal of Applied Toxicology

Volumn 34, Issue 2, 2014, Pages 127-138

  Alarcón Aguilar, Adriana ^a   González Puertos, Viridiana Yazmín ^a   Luna López, Armando ^b   López Macay, Ambar ^a   Morán, Julio ^c   Santamaría, Abel ^b   Königsberg, Mina ^a  

^a DEPARTAMENTO DE QUÍMICA   (Mexico)

^b HOSPITAL GENERAL DE MÉXICO   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

amyloid peptide; Astrocyte primary cultures; Cytotoxicity; MPP+; Oxidative stress

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; AMYLOID BETA PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; NEUROTOXIN;

ADULT ANIMAL; AGING; ANIMAL CELL; ARTICLE; ASTROCYTE; ASTROCYTE CULTURE; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CORTICAL ASTROCYTE; CYTOTOXICITY; FRONTAL CORTEX; GROUPS BY AGE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LIPID OXIDATION; LIPID PEROXIDATION; MITOCHONDRIAL FUNCTIONALITY; MITOCHONDRION; NEWBORN; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN OXIDATION; RAT; WESTERN BLOTTING;

RATTUS;

ASTROCYTE PRIMARY CULTURES; CYTOTOXICITY; MPP+; OXIDATIVE STRESS; Β-AMYLOID PEPTIDE;

1-METHYL-4-PHENYLPYRIDINIUM; AGING; AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; BRAIN; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPID PEROXIDATION; MITOCHONDRIA; NEUROTOXINS; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84890426544     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2841     Document Type: Article

References (59)

1. Abramov AY, Canevari L, Duchen MR. 2004. Calcium signals induced by amyloid beta peptide and their consequences in neurons and astrocytes in culture. Biochim. Biophys. Acta 1742: 81-87.
2. Adibhatla RM, Hatcher JF. 2010. Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid. Redox Signal. 12: 125-169.
3. Arnold SE, Smutzer GS, Trojanowski JQ, Moberg PJ. 1998. Cellular and molecular neuropathology of the olfactory epithelium and central olfactory pathways in Alzheimer's disease and schizophrenia. Ann. N. Y. Acad. Sci. 855: 762-775.
4. Baillet A, Chanteperdrix V, Trocmé C, Casez P, Garrel C, Besson G. 2010. The role of oxidative stress in amyotrophic lateral sclerosis and Parkinson's disease. Neurochem. Res. 35: 1530-1537.
5. Bhat R, Crowe EP, Bitto A, Moh M, Katsetos CD, Garcia FU, Johnson FB, Trojanowski JQ, Sell C, Torres C. 2012. Astrocyte senescence as a component of Alzheimer's disease. PLoS One 7: e45069.
6. Bisaglia M, Venezia V, Biglieri M, Russo C, Mancini F, Milanese C, Schettini G. 2004. Alpha-Glycerylphosphorylethanolamine rescues astrocytes from mitochondrial impairment and oxidative stress induced by amyloid beta-peptides. Neurochem. Int. 44: 161-170.
7. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.
8. Chen H, Sen W, Jian-Hua D, Gang H. 2008. Edaravone protects against MPP+-induced cytotoxicity in rat primary cultured astrocytes via inhibition of mitochondrial apoptotic pathway. J. Neurochem. 106: 2345-2352.
9. Chen J, Zhang X, Kusumo H, Costa LG, Guizzetti M. 2012.Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis. Biochim. Biophys. Acta 1831: 263-275.
10. Chuang JI, Chen TH. 2004. Effect of melatonin on temporal changes of reactive oxygen species and glutathione after MPP (+) treatment in human astrocytoma U373MG cells. J. Pineal Res. 36: 117-125.
11. Cillero-Pastor B, Martin MA, Arenas J, López-Armada MJ, Blanco FJ. 2011. Effect of nitric oxide on mitochondrial activity of human synovial cells. BMC Musculo. Skelet. Disord. 8: 42.
12. Croce N, Dinallo V, Ricci V, Federici G, Caltagirone C, Bernardini S, Angelucci F. 2011. Neuroprotective effect of neuropeptide Y against β-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production. Neurodegener Dis 8: 300-309.
13. Di Monte DA, Tokar I, Langston JW. 1999. Impaired glutamate clearance as a consequence of energy failure caused by MPP(+) in astrocytic cultures. Toxicol. Appl. Pharmacol. 158: 296-302.
14. Di Monte DA, Wu EY, Langston JW. 1992. Role of astrocytes in MPTP metabolism and toxicity. Ann. N. Y. Acad. Sci. 11: 219-228.
15. Dringen R. 2000. Metabolism and functions of glutathione in brain. Prog. Neurobiol. 62: 649-671.
16. Fernández-Checa JC, Fernández A, Morales A, Marí M, García-Ruiz C, Colell A. 2010. Oxidative stress and altered mitochondrial function in neurodegenerative diseases: lessons from mouse models. CNS Neurol. Disord. Drug Targets 9: 439-454.
17. Ferrera P, Mercado-Gómez O, Silva-Aguilar M, Valverde M, Arias C. 2008. Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress. Neurochem. Res. 33: 1509-1517.
18. Friedlander RM. 2003. Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med. 348: 1365-1375.
19. Giulian D, Vaca K, Corpuz M. 1993. Brain glia release factors with opposing actions upon neuronal survival. J. Neurosci. 13: 29-37.
20. Golomb E, Matza D, Cummings CA, Schwalb H, Kodavanti UP, Schneider A, Houminer E, Korach A, Nyska A, Shapira OM. 2012. Myocardial mitochondrial injury induced by pulmonary exposure to particulate matter in rats. Toxicol. Pathol. 40: 779-788.
21. Halassa MM, Fellin T, Haydon PG. 2009. Tripartite synapses: roles for astrocytic purines in the control of synaptic physiology and behavior. Neuropharmacology 57: 343-346.
22. Hazell AS, Itzhak Y, Liu H, Norenberg MD. 1997. 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. J. Neurochem. 68: 2216-2219.
23. Hu J, Akama KT, Krafft GA, Chromy BA, Van-Eldik LJ. 1998. Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release. Brain Res. 2: 195-206.
24. Hu LF, Wang S, Shi XR, Yao HH, Sun YH, Ding JH, Liu SY, Hu G. 2005. ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level. J. Neurochem. 94: 1570-1579.
25. Jeong JC, Yoon CH, Lee WH, Park KK, Chang YC, Choi YH, Kim CH. 2005. Effects of Bambusae concretio Salicea (Chunchukhwang) on amyloid beta-induced cell toxicity and antioidative enzymes in cultured rat neuronal astrocytes. J. Ethnopharmacol. 98: 259-266.
26. Jia Z, Zhu H, Li Y, Misra HP. 2009. Cruciferous nutraceutical 3H-1, 2-dithiole-3-thione protects human primary astrocytes against neurocytotoxicity elicited by MPTP, MPP(+), 6-OHDA, HNE and acrolein. Neurochem. Res. 34: 1924-1934.
27. Johnstone M, Gearing AJ, Miller KM. 1999. A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced. J. Neuroimmunol. 93: 182-193.
28. Kanwar SS, Nehru B. 2007. Modulatory effects of N-acetylcysteine on cerebral cortex and cerebellum regions of ageing rat brain. Nutr. Hosp. 22: 95-100.
29. Lee Y, Lee KS, Lee HJ, Kim H, Noh YH, Yu K, Jung HY, Lee SH, Lee JY, Youn YC, Jeong Y, Kim DK, Lee WB, Kim SS. 2010. Activation of PERK signaling attenuates Abeta-mediated ER stress. PLoS One 5: e10489.
30. Lin DT, Wu J, Holstein D, Upadhyay G, Rourk W, Muller E, Lechleiter JD. 2007. Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes. Neurobiol. Aging 28: 99-111.
31. Malchiodi-Albedi F, Domenici MR, Paradisi S, Bernardo A, Ajmone-Cat MA, Minghetti L. 2001. Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons. Glia 34: 68-72.
32. Mallajosyula JK, Kaur D, Chinta SJ, Rajagopalan S, Rane A, Nicholls DG, Di Monte DA, Macarthur H, Andersen JK. 2008. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PLoS One 3: e1616.
33. Matyash V, Kettenmann H. 2010. Heterogeneity in astrocyte morphology and physiology. Brain Res. Rev. 63: 2-10.
34. McCarthy KF, de Vellis J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85: 890-902.
35. Molofsky AV, Krencik R, Ullian EM, Tsai HH, Deneen B, Richardson WD, Barres BA, Rowitch DH. 2012. Astrocytes and disease: a neurodevelopmental perspective. Genes Dev. 26: 891-907.
36. Mosmann T. 1983. Rapid colorimentric assay for cellular growth and survival: application of proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63. DOI: org/10.1016/0022-1759(83)90303-4.
37. Paradisi S, Sacchetti B, Balduzzi M, Gaudi S, Malchiodi-Albedi F. 2004. Astrocyte modulation of in vitro beta-amyloid neurotoxicity. Glia 46: 252-260.
38. Pentreath VW, Mead C. 2004. Responses of cultured astrocytes, C6 glioma and 1321NI astrocytoma cells to amyloid beta-peptide fragments. Nonlinearity Biol. Toxicol. Med. 2: 45-63.
39. Peña F, Gutiérrez-Lerma A, Quiroz-Baez R, Arias C. 2006. The role of beta-amyloid protein in synaptic function: implications for Alzheimer's disease therapy. Curr. Neuropharmacol. 4: 149-163.
40. Pertusa M, Garcia-Matas S, Rodriguez-Farre E, Sanfeliu C, Cristofol R. 2007. Astrocytes aged in vitro show a decreased neuroprotective capacity. J. Neurochem. 101: 794-805.
41. Przedborski S, Vila M. 2003. The 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Ann. N. Y. Acad. Sci. U. S. A. 991: 189-198.
42. Reale M, Kamal MA, Velluto L, Gambi D, Di Nicola M, Greig NH. 2012. Relationship between inflammatory mediators, Aβ levels and ApoE genotype in Alzheimer disease. Curr. Alzheimer Res. 9: 447-457.
43. Ren R, Zhang Y, Li B, Wu Y, Li B. 2011. Effect of β-amyloid (25-35) on mitochondrial function and expression of mitochondrial permeability transition pore proteins in rat hippocampal neurons. J. Cell. Biochem. 112: 1450-1457.
44. Rogers J, Strohmeyer R, Kovelowski CJ, Li R. 2002. Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40: 260-269.
45. Sánchez NS, Konigsberg M. 2006. Using yeast to easily determine mitochondrial functionality with MTT assay. Biochem. Mol. Biol. Educ. 34: 209-212.
46. Scheiber IF, Dringen R. 2012. Astrocyte functions in the copper homeostasis of the brain. Neurochem. Int. S0197: 284-287.
47. Simonian NA, Coyle JT. 1996. Oxidative stress in neurodegenerative diseases. Ann. Rev. Pharmacol. Toxicol. 36: 83-106.
48. Sofroniew MV, Vinters HV. 2010. Astrocytes: biology and pathology. Acta Neuropathol. 119: 7-35.
49. Takuma K, Baba A, Matsuda T. 2004. Astrocyte apoptosis: implications for neuroprotection. Prog. Neurobiol. 72: 111-127.
50. Ting KK, Brew BJ, Guillemin GJ. 2009. Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease. J. Neuroinflammation 6: 36.
51. Tsai MJ, Lee EH. 1994. Differences in the disposition and toxicity of 1-methyl-4-phenylpyridinium in cultured rat and mouse astrocytes. Glia 12: 329-335.
52. Tsai MJ, Lee EH. 1998. Nitric oxide donors protect cultured rat astrocytes from 1-methyl-4-phenylpyridinium-induced toxicity. Free Radic. Biol. Medic. 23: 705-713.
53. Valles SL, Dolz-Gaiton P, Gambini J, Borras C, Lloret A, Pallardo FV, Viña J. 2010. Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes. Brain Res. 1312: 138-144.
54. Volterra A, Meldolesi J, 2005. Astrocytes, from brain glue to communication elements: the revolution continues. Nat. Rev. Neurosci. 6: 626-640.
55. Wilson JX. 1997. Antioxidant defense of the brain: a role for astrocytes. Can. J. Physiol. Pharmacol. 75: 1149-1163.
56. Wu EY Langston JW, Di Monte DA. 1992. Toxicity of the 1-methyl-4-phenyl-2, 3-dihydropyridinium and 1-methyl-4-phenylpyridinium species in primary cultures of mouse astrocytes. J. Pharmacol. Exp. Ther. 262: 225-230.
57. Yao HH, Ding JH, Zhou F, Wang F, Hu LF, Sun T, Hu G. 2005. Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes. J. Neurochem. 92: 948-961.
58. Zentella de Piña M, Sandoval-Montiel A, Serrano-Alessandri L, Montalvo-Jave E, Zentella-Dehesa A, Piña E. 2007. Ethanol-mediated oxidative changes in blood lipids and proteins are reversed by aspirin-like drugs. Arch. Med. Res. 38: 269-275.
59. Zhang D, Hu X, Qian L, O'Callaghan JP, Hong JS. 2010. Astrogliosis in CNS is there a role for microglia? Mol. Neurobiol. 41: 232-241.