Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: Implications in maintenance of intervertebral disc health

Oncotarget

Volumn 7, Issue 17, 2016, Pages 23056-23071

  Suyama, Kaori ^a,b   Silagi, Elizabeth S ^a,c   Choi, Hyowon ^a,c   Sakabe, Kou ^b   Mochida, Joji ^b   Shapiro, Irving M ^a,c   Risbud, Makarand V ^a,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

BMAL1; HIF 1; Intervertebral disc; Nucleus pulposus; Pathology Section; RORa

Indexed keywords

CELL NUCLEUS RECEPTOR; ENOLASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATASE; PROTEIN PFKFB3; PROTEIN ROR ALPHA; PROTEIN TAD; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG; VASCULOTROPIN; RETINOID RELATED ORPHAN RECEPTOR ALPHA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL FUNCTION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DISC HEIGHT; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; HEIGHT; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEUS PULPOSUS; PHENOTYPE; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; ANIMAL; C57BL MOUSE; CELL CULTURE; GENETICS; INTERVERTEBRAL DISK; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; CELLS, CULTURED; CIRCADIAN RHYTHM; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERVERTEBRAL DISC; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; NUCLEUS PULPOSUS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84966472281     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8521     Document Type: Article

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