Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells

Oncotarget

Volumn 6, Issue 14, 2015, Pages 11945-11958

  Johnson, Zariel I ^a   Gogate, Shilpa S ^a   Day, Rebecca ^b   Binch, Abbie ^b   Markova, Dessislava Z ^a   Chiverton, Neil ^c   Cole, Ashley ^c   Conner, Matt ^b   Shapiro, Irving M ^a   Le Maitre, Christine L ^b   Risbud, Makarand V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^c SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Aquaporin 1; Aquaporin 5; HIF 1; Intervertebral disc; Nucleus pulposus

Indexed keywords

AQUAPORIN 1; AQUAPORIN 5; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; AQP5 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN;

ADULT; ANIMAL CELL; ARTICLE; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GAIN OF FUNCTION MUTATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA RESPONSIVE ELEMENT; INTERVERTEBRAL DISK DEGENERATION; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEUS PULPOSUS; OXYGEN TENSION; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; ANIMAL; BIOSYNTHESIS; CELL HYPOXIA; DNA RESPONSIVE ELEMENT; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; METABOLISM; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; AQUAPORIN 1; AQUAPORIN 5; BLOTTING, WESTERN; CELL HYPOXIA; CHROMATIN IMMUNOPRECIPITATION; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC DEGENERATION; MICROSCOPY, FLUORESCENCE; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RESPONSE ELEMENTS; TRANSFECTION;

EID: 84931364532     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3631     Document Type: Article

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