Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells

Phytomedicine

Volumn 23, Issue 7, 2016, Pages 736-744

  Naveen, C R ^a   Gaikwad, Sagar ^a   Agrawal Rajput, Reena ^a  

^a Indian Institute of Advanced Research   (India)

Author keywords

Berberine; Cancer stemness; Cell cycle; Differentiation; EMT; Neuroblastoma

Indexed keywords

BERBERINE; BETA CATENIN; BETA TUBULIN; CD133 ANTIGEN; CYCLIN DEPENDENT KINASE; CYCLINE; FIBRONECTIN; GELATINASE A; GELATINASE B; GLUCOSE; HEAT SHOCK PROTEIN 70; LAMININ; MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE CELL ADHESION MOLECULE; NESTIN; NOTCH2 RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P27; SMAD PROTEIN; TRANSCRIPTION FACTOR SOX2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; TUMOR SUPPRESSOR PROTEIN; UVOMORULIN; VIMENTIN; ANTINEOPLASTIC AGENT; TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL PROLIFERATION; DOWN REGULATION; ENZYME INDUCTION; EPITHELIAL MESENCHYMAL TRANSITION; G1 PHASE CELL CYCLE CHECKPOINT; IMMUNOFLUORESCENCE; MOUSE; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA CELL; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN INTERACTION; REVERSAL POTENTIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CANCER STEM CELL; CELL CYCLE CHECKPOINT; CELL DIFFERENTIATION; DRUG EFFECTS; METABOLISM; NERVE CELL; NEUROBLASTOMA; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BERBERINE; BIOMARKERS, TUMOR; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; MICE; NEOPLASTIC STEM CELLS; NEUROBLASTOMA; NEURONS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84966372765     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2016.03.013     Document Type: Article

References (30)

1. I. Ajioka Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family Dev. Growth Differ. 56 2014 324 334
2. T. Brabletz EMT and MET in metastasis: where are the cancer stem cells? Cancer Cell 22 2012 699 701
3. Cai Y., Xia Q., Luo R., Huang P., Sun Y., Shi Y., Jiang W. Berberine inhibits the growth of human colorectal adenocarcinoma in vitro and in vivo J. Nat. Med. 68 2014 53 62
4. Chen C.C., Hung T.H., Lee C.Y., Wang L.F., Wu C.H., Ke C.H., Chen S.F. Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury PLoS One 9 2014 e115694
5. Chen X.W., Di Y.M., Zhang J., Zhou Z.W., Li C.G., Zhou S.F. Interaction of herbal compounds with biological targets: a case study with berberine Sci. World J. 2012 2012 708292
6. J.M. Cheng, J.L. Hiemstra, S.S. Schneider, A. Naumova, N.K. Cheung, S.L. Cohn, L. Diller, C. Sapienza, G.M. Brodeur Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas Nat. Genet. 4 1993 191 194
7. T.F. Eleveld, D.A. Oldridge, V. Bernard, J. Koster, L.C. Daage, S.J. Diskin, L. Schild, N.B. Bentahar, A. Bellini, M. Chicard, E. Lapouble, V. Combaret, P. Legoix-Ne, J. Michon, T.J. Pugh, L.S. Hart, J. Rader, E.F. Attiyeh, J.S. Wei, S. Zhang, A. Naranjo, J.M. Gastier-Foster, M.D. Hogarty, S. Asgharzadeh, M.A. Smith, J.M. Guidry Auvil, T.B. Watkins, D.A. Zwijnenburg, M.E. Ebus, P. van Sluis, A. Hakkert, E. van Wezel, C.E. van der Schoot, E.M. Westerhout, J.H. Schulte, G.A. Tytgat, M.E. Dolman, I. Janoueix-Lerosey, D.S. Gerhard, H.N. Caron, O. Delattre, J. Khan, R. Versteeg, G. Schleiermacher, J.J. Molenaar, J.M. Maris Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations Nat. Genet. 47 2015 864 871
8. S. Gaikwad, R. Agrawal-Rajput Lipopolysaccharide from Rhodobacter sphaeroides attenuates microglia-mediated inflammation and phagocytosis and directs regulatory t cell response Int. J. Inflam. 2015 2015 361326
9. E.F. Garner, E.A. Beierle Cancer stem cells and their interaction with the tumor microenvironment in neuroblastoma Cancers (Basel) 8 2015
10. G. Gatta, R. Capocaccia, M.P. Coleman, L.A. Ries, F. Berrino Childhood cancer survival in Europe and the United States Cancer 95 2002 1767 1772
11. M. Imanshahidi, H. Hosseinzadeh Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine Phytother. Res. 22 2008 999 1012
12. R. Kalluri, R.A. Weinberg The basics of epithelial-mesenchymal transition J. Clin. Invest. 119 2009 1420 1428
13. K. Kessenbrock, V. Plaks, Z. Werb Matrix metalloproteinases: regulators of the tumor microenvironment Cell 141 2010 52 67
14. S. Lamouille, Xu J., R. Derynck Molecular mechanisms of epithelial-mesenchymal transition Nat. Rev. Mol. Cell Biol. 15 2014 178 196
15. H.A. Lee, S. Park, Y. Kim Effect of beta-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells Oncol. Rep. 30 2013 1869 1877
16. Li G.H., Wang D.L., Hu Y.D., Pu P., Li D.Z., Wang W.D., Zhu B., Hao P., Wang J., Xu X.Q., Wan J.Q., Zhou Y.B., Chen Z.T. Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy Med. Oncol. 27 2010 919 925
17. C.U. Louis, J.M. Shohet Neuroblastoma: molecular pathogenesis and therapy Annu. Rev. Med. 66 2015 49 63
18. Lv Z.M., Wang Q., Wan Q., Lin J.G., Hu M.S., Liu Y.X., Wang R. The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cells PLoS One 6 2011 e22806
19. A. Nakagawara, M. Ohira Comprehensive genomics linking between neural development and cancer: neuroblastoma as a model Cancer Lett. 204 2004 213 224
20. J.L. Nitiss Targeting DNA topoisomerase II in cancer chemotherapy Nat. Rev. Cancer 9 2009 338 350
21. V. Pongkittiphan, W. Chavasiri, R. Supabphol Antioxidant effect of berberine and its phenolic derivatives against human fibrosarcoma cells Asian Pac. J. Cancer Prev. 16 2015 5371 5376
22. D. Rathee, M. Thanki, S. Bhuva, S. Anandjiwala, R. Agrawal Iridoid glycosides-Kutkin, Picroside I, and Kutkoside from Picrorrhiza kurroa Benth inhibits the invasion and migration of MCF-7 breast cancer cells through the down regulation of matrix metalloproteinases: 1st Cancer Update Arabian J. Chem. 6 2013 49 58
23. R. Seidenfaden, A. Krauter, F. Schertzinger, R. Gerardy-Schahn, H. Hildebrandt Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions Mol. Cell Biol. 23 2003 5908 5918
24. D. Tomar, L. Sripada, P. Prajapati, R. Singh, A.K. Singh Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-kappaB pathway PLoS One 7 2012 e48662
25. J.H. Tsai, J.L. Donaher, D.A. Murphy, S. Chau, J. Yang Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis Cancer Cell 22 2012 725 736
26. C. von Mering, M. Huynen, D. Jaeggi, S. Schmidt, P. Bork, B. Snel STRING: a database of predicted functional associations between proteins Nucleic Acids Res. 31 2003 258 261
27. J.D. Walton, D.R. Kattan, S.K. Thomas, B.A. Spengler, H.F. Guo, J.L. Biedler, N.K. Cheung, R.A. Ross Characteristics of stem cells from human neuroblastoma cell lines and in tumors Neoplasia 6 2004 838 845
28. Wang N., Tan H.Y., Li L., Yuen M.F., Feng Y. Berberine and Coptidis Rhizoma as potential anticancer agents: recent updates and future perspectives J. Ethnopharmacol. 176 2015 35 48
29. A. Wey, P.S. Knoepfler c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain Oncotarget 1 2010 120 130
30. Yuan L., Xu P.L., Zeng Q., Liu Y.M., Ding L.S., Liao X. Preparation of ds-DNA functionalized magnetic nanobaits for screening of bioactive compounds from medicinal plant Mater Sci. Eng. C Mater. Biol. Appl. 56 2015 401 408