메뉴 건너뛰기




Volumn 66, Issue , 2015, Pages 49-63

Neuroblastoma: Molecular pathogenesis and therapy

Author keywords

cancer biology; epigenetics; epithelial to mesenchymal transition; neural crest development; neuroblastoma; oncogenes; pediatric cancer

Indexed keywords

UNTRANSLATED RNA;

EID: 84921417441     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-011514-023121     Document Type: Article
Times cited : (279)

References (95)
  • 1
    • 84863206246 scopus 로고    scopus 로고
    • CDC. U.S. Cancer Statistics Working Group. US Dep. HealthHum. Serv., Cent. Disease Control Prev. andNatl. Cancer Inst.
    • CDC. U.S. Cancer Statistics Working Group. 2013. United States Cancer Statistics: 1999-2010 incidence and mortality web-based report. US Dep. HealthHum. Serv., Cent. Disease Control Prev. andNatl. Cancer Inst.
    • (2013) United States Cancer Statistics 1999-2010 Incidence and Mortality Web-based Report
  • 2
    • 27244460626 scopus 로고    scopus 로고
    • Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group
    • London WB, Castleberry RP, Matthay KK, et al. 2005. Evidence for an age cutoff greater than 365 days for neuroblastoma risk group stratification in the Children's Oncology Group. J. Clin. Oncol. 23:6459-65
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6459-6465
    • London, W.B.1    Castleberry, R.P.2    Matthay, K.K.3
  • 3
    • 58249093954 scopus 로고    scopus 로고
    • The International Neuroblastoma Risk Group (INRG) staging system: An INRG Task Force report
    • Monclair T, Brodeur GM, Ambros PF, et al. 2009. The International Neuroblastoma Risk Group (INRG) staging system: an INRG Task Force report. J. Clin. Oncol. 27:298-303
    • (2009) J. Clin. Oncol. , vol.27 , pp. 298-303
    • Monclair, T.1    Brodeur, G.M.2    Ambros, P.F.3
  • 4
    • 84876430459 scopus 로고    scopus 로고
    • Children's Oncology Group's 2013 blueprint for research: Neuroblastoma
    • Park JR, Bagatell R, London WB, et al. 2013. Children's Oncology Group's 2013 blueprint for research: neuroblastoma. Pediatr. Blood Cancer 60:985-93
    • (2013) Pediatr. Blood Cancer , vol.60 , pp. 985-993
    • Park, J.R.1    Bagatell, R.2    London, W.B.3
  • 5
    • 84921396799 scopus 로고    scopus 로고
    • Update on outcome for high-risk neuroblastoma treated on a randomized trial of chimeric anti-gd2 antibody (ch14.18) + GM-CSF/IL2 in first response: A Children's Oncology Group study
    • Yu AL. 2014. Update on outcome for high-risk neuroblastoma treated on a randomized trial of chimeric anti-gd2 antibody (ch14.18) + GM-CSF/IL2 in first response: a Children's Oncology Group study. Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne
    • (2014) Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne
    • Yu, A.L.1
  • 6
    • 77955280205 scopus 로고    scopus 로고
    • Analysis of early human neural crest development
    • Betters E, Liu Y, Kjaeldgaard A, et al. 2010. Analysis of early human neural crest development. Dev. Biol. 344:578-92
    • (2010) Dev. Biol. , vol.344 , pp. 578-592
    • Betters, E.1    Liu, Y.2    Kjaeldgaard, A.3
  • 7
    • 52949154642 scopus 로고    scopus 로고
    • High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma
    • Fredlund E, RingnerM, Maris JM, Pahlman S. 2008. High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma. Proc. Natl. Acad. Sci. USA 105:14094-99
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14094-14099
    • Fredlund, E.1    Ringner, M.2    Maris, J.M.3    Pahlman, S.4
  • 8
    • 84882756365 scopus 로고    scopus 로고
    • Tissue interactions in neural crest cell development and disease
    • Takahashi Y, Sipp D, Enomoto H. 2013. Tissue interactions in neural crest cell development and disease. Science 341:860-63
    • (2013) Science , vol.341 , pp. 860-863
    • Takahashi, Y.1    Sipp, D.2    Enomoto, H.3
  • 9
    • 0033934034 scopus 로고    scopus 로고
    • The neural crest as a fourth germ layer and vertebrates as quadroblastic not triploblastic
    • Hall BK. 2000. The neural crest as a fourth germ layer and vertebrates as quadroblastic not triploblastic. Evol. Dev. 2:3-5
    • (2000) Evol. Dev. , vol.2 , pp. 3-5
    • Hall, B.K.1
  • 10
    • 84860838210 scopus 로고    scopus 로고
    • Induction of the neural crest state: Control of stem cell attributes by gene regulatory, post-Transcriptional and epigenetic interactions
    • Prasad MS, Sauka-Spengler T, Labonne C. 2012. Induction of the neural crest state: control of stem cell attributes by gene regulatory, post-Transcriptional and epigenetic interactions. Dev. Biol. 366:10-21
    • (2012) Dev. Biol. , vol.366 , pp. 10-21
    • Prasad, M.S.1    Sauka-Spengler, T.2    Labonne, C.3
  • 11
    • 84887446499 scopus 로고    scopus 로고
    • Transcriptional and epigenetic regulation of neural crest induction during neurulation
    • MayanilCS. 2013. Transcriptional and epigenetic regulation of neural crest induction during neurulation. Dev. Neurosci. 35(5):361-72
    • (2013) Dev. Neurosci. , vol.35 , Issue.5 , pp. 361-372
    • Mayanil, C.S.1
  • 12
    • 84866339845 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition: New and old insights from the classical neural crest model
    • Strobl-Mazzulla PH, BronnerME. 2012. Epithelial to mesenchymal transition: new and old insights from the classical neural crest model. Semin. Cancer Biol. 22(5-6):411-16
    • (2012) Semin. Cancer Biol. , vol.22 , Issue.5-6 , pp. 411-416
    • Strobl-Mazzulla, P.H.1    Bronner, M.E.2
  • 13
    • 84875843952 scopus 로고    scopus 로고
    • Signaling and transcriptional regulation in neural crest specification and migration: Lessons from xenopus embryos
    • Wiley Interdiscip
    • Pegoraro C, Monsoro-Burq AH. 2013. Signaling and transcriptional regulation in neural crest specification and migration: lessons from xenopus embryos. Wiley Interdiscip. Rev. Dev. Biol. 2:247-59
    • (2013) Rev. Dev. Biol. , vol.2 , pp. 247-259
    • Pegoraro, C.1    Monsoro-Burq, A.H.2
  • 14
    • 84879064273 scopus 로고    scopus 로고
    • Sympathetic neurons and chromaffin cells share a common progenitor in the neural crest in vivo
    • Shtukmaster S, Schier MC, Huber K, et al. 2013. Sympathetic neurons and chromaffin cells share a common progenitor in the neural crest in vivo. Neural Dev. 18(8):12
    • (2013) Neural Dev. , vol.18 , Issue.8 , pp. 12
    • Shtukmaster, S.1    Schier, M.C.2    Huber, K.3
  • 15
    • 84905028227 scopus 로고    scopus 로고
    • Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression
    • Denecker G, Vandamme N, Akay O, et al. 2014. Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 21(8):1250-61
    • (2014) Cell Death Differ. , vol.21 , Issue.8 , pp. 1250-1261
    • Denecker, G.1    Vandamme, N.2    Akay, O.3
  • 16
    • 84880939077 scopus 로고    scopus 로고
    • Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification
    • Powell DR, Hernandez-Lagunas L, LaMonica K, Artinger KB. 2013. Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification. Development 140:3445-55
    • (2013) Development , vol.140 , pp. 3445-3455
    • Powell, D.R.1    Hernandez-Lagunas, L.2    Lamonica, K.3    Artinger, K.B.4
  • 17
    • 79960558235 scopus 로고    scopus 로고
    • Prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate border
    • Hernandez-Lagunas L, Powell DR, Law J, et al. 2011. prdm1a and olig4 act downstream of Notch signaling to regulate cell fate at the neural plate border. Dev. Biol. 356:496-505
    • (2011) Dev. Biol. , vol.356 , pp. 496-505
    • Hernandez-Lagunas, L.1    Powell, D.R.2    Law, J.3
  • 18
    • 84890826207 scopus 로고    scopus 로고
    • Sip1 mediates an E-cadherin-To-N-cadherin switch during cranial neural crest EMT
    • Rogers CD, Saxena A, Bronner ME. 2013. Sip1 mediates an E-cadherin-To-N-cadherin switch during cranial neural crest EMT. J. Cell Biol. 203:835-47
    • (2013) J. Cell Biol. , vol.203 , pp. 835-847
    • Rogers, C.D.1    Saxena, A.2    Bronner, M.E.3
  • 19
    • 84884558125 scopus 로고    scopus 로고
    • Unravelling cancer stem cell potential
    • Beck B, Blanpain C. 2013. Unravelling cancer stem cell potential. Nat. Rev. Cancer 13:727-38
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 727-738
    • Beck, B.1    Blanpain, C.2
  • 20
    • 84890681784 scopus 로고    scopus 로고
    • Genetic diversity in normal cell populations is the earliest stage of oncogenesis leading to intra-Tumor heterogeneity
    • Howk CL, Voller Z, Beck BB, Dai D. 2013. Genetic diversity in normal cell populations is the earliest stage of oncogenesis leading to intra-Tumor heterogeneity. Front. Oncol. 5(3):61
    • (2013) Front. Oncol. , vol.5 , Issue.3 , pp. 61
    • Howk, C.L.1    Voller, Z.2    Beck, B.B.3    Dai, D.4
  • 21
    • 84880075721 scopus 로고    scopus 로고
    • G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic
    • Hsu DM, Agarwal S, Benham A, et al. 2013. G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic. Cancer Res. 73:4134-46
    • (2013) Cancer Res. , vol.73 , pp. 4134-4146
    • Hsu, D.M.1    Agarwal, S.2    Benham, A.3
  • 22
    • 84866540759 scopus 로고    scopus 로고
    • A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: A children's oncology group study
    • Nuchtern JG, London WB, Barnewolt CE, et al. 2012. A prospective study of expectant observation as primary therapy for neuroblastoma in young infants: a Children's Oncology Group study. Ann. Surg. 256:573-80
    • (2012) Ann. Surg. , vol.256 , pp. 573-580
    • Nuchtern, J.G.1    London, W.B.2    Barnewolt, C.E.3
  • 23
    • 84863928229 scopus 로고    scopus 로고
    • Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: Results of children's oncology group study p9641
    • Strother DR, London WB, Schmidt ML, et al. 2012. Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children's Oncology Group study P9641. J. Clin. Oncol. 30:1842-48
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1842-1848
    • Strother, D.R.1    London, W.B.2    Schmidt, M.L.3
  • 24
    • 79955428953 scopus 로고    scopus 로고
    • P53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes
    • Rinon A, Molchadsky A, Nathan E, et al. 2011. p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. Development 138:1827-38
    • (2011) Development , vol.138 , pp. 1827-1838
    • Rinon, A.1    Molchadsky, A.2    Nathan, E.3
  • 25
    • 67650457657 scopus 로고    scopus 로고
    • Mdm2 deficiency suppresses MYCN-driven neuroblastoma tumorigenesis in vivo
    • Chen Z, Lin Y, Barbieri E, et al. 2009. Mdm2 deficiency suppresses MYCN-driven neuroblastoma tumorigenesis in vivo. Neoplasia 11:753-62
    • (2009) Neoplasia , vol.11 , pp. 753-762
    • Chen, Z.1    Lin, Y.2    Barbieri, E.3
  • 26
    • 72949107687 scopus 로고    scopus 로고
    • Targeted molecular therapy for neuroblastoma: The ARF/MDM2/p53 axis
    • Kim E, Shohet J. 2009. Targeted molecular therapy for neuroblastoma: the ARF/MDM2/p53 axis. J. Natl. Cancer Inst. 101:1527-29
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 1527-1529
    • Kim, E.1    Shohet, J.2
  • 27
    • 84874664731 scopus 로고    scopus 로고
    • The genetic landscape of high-risk neuroblastoma
    • Pugh TJ, Morozova O, Attiyeh EF, et al. 2013. The genetic landscape of high-risk neuroblastoma. Nat. Genet. 45:279-84
    • (2013) Nat. Genet. , vol.45 , pp. 279-284
    • Pugh, T.J.1    Morozova, O.2    Attiyeh, E.F.3
  • 28
    • 46849107117 scopus 로고    scopus 로고
    • CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas
    • Fujita T, Igarashi J, Okawa ER, et al. 2008. CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas. J. Natl. Cancer Inst. 100:940-49
    • (2008) J. Natl. Cancer Inst. , vol.100 , pp. 940-949
    • Fujita, T.1    Igarashi, J.2    Okawa, E.R.3
  • 29
    • 84902188451 scopus 로고    scopus 로고
    • Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma
    • Theissen J, Oberthuer A, Hombach A, et al. 2014. Chromosome 17/17q gain and unaltered profiles in high resolution array-CGH are prognostically informative in neuroblastoma. Genes Chromosomes Cancer 53(8):639-49
    • (2014) Genes Chromosomes Cancer , vol.53 , Issue.8 , pp. 639-649
    • Theissen, J.1    Oberthuer, A.2    Hombach, A.3
  • 30
    • 77649159750 scopus 로고    scopus 로고
    • Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature
    • De Preter K, Vermeulen J, Brors B, et al. 2010. Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature. Clin. Cancer Res. 16:1532-41
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1532-1541
    • De Preter, K.1    Vermeulen, J.2    Brors, B.3
  • 31
    • 55649123695 scopus 로고    scopus 로고
    • Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
    • Westermann F, Muth D, Benner A, et al. 2008. Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas. Genome Biol. 13;9(10):R1509
    • (2008) Genome Biol. 13 , vol.9 , Issue.10 , pp. R1509
    • Westermann, F.1    Muth, D.2    Benner, A.3
  • 32
    • 33644701818 scopus 로고    scopus 로고
    • Inferring a tumor progression model for neuroblastoma from genomic data
    • Bilke S, Chen QR, Westerman F, et al. 2005. Inferring a tumor progression model for neuroblastoma from genomic data. J. Clin. Oncol. 23:7322-31
    • (2005) J. Clin. Oncol. , vol.23 , pp. 7322-7331
    • Bilke, S.1    Chen, Q.R.2    Westerman, F.3
  • 33
    • 4344606588 scopus 로고    scopus 로고
    • Mechanisms of embryonal tumor initiation: Distinct roles for MycN expression and MYCN amplification
    • Hansford LM, ThomasWD, Keating JM, et al. 2004. Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. Proc. Natl. Acad. Sci. USA 101:12664-69
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 12664-12669
    • Hansford, L.M.1    Thomas, W.D.2    Keating, J.M.3
  • 34
    • 0030999641 scopus 로고    scopus 로고
    • Targeted expression of MYCN causes neuroblastoma in transgenic mice
    • WeissWA, Aldape K, Mohapatra G, et al. 1997. Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 16:2985-95
    • (1997) EMBO J. , vol.16 , pp. 2985-2995
    • Weiss, W.A.1    Aldape, K.2    Mohapatra, G.3
  • 35
    • 84870242293 scopus 로고    scopus 로고
    • Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-Amplified neuroblastoma
    • Schramm A, Koster J, Marschall T, et al. 2013. Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-Amplified neuroblastoma. Int. J. Cancer 132:E106-15
    • (2013) Int. J. Cancer 132:E106-15
    • Schramm, A.1    Koster, J.2    Marschall, T.3
  • 36
    • 64249092932 scopus 로고    scopus 로고
    • MicroRNA involvement in the pathogenesis of neuroblastoma: Potential for microRNA mediated therapeutics
    • Stallings RL. 2009. MicroRNA involvement in the pathogenesis of neuroblastoma: potential for microRNA mediated therapeutics. Curr. Pharm. Des. 15:456-62
    • (2009) Curr. Pharm. Des. , vol.15 , pp. 456-462
    • Stallings, R.L.1
  • 37
    • 84869779376 scopus 로고    scopus 로고
    • A functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
    • Valentijn LJ, Koster J, Haneveld F, et al. 2012. A functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Proc. Natl. Acad. Sci. USA 109(47):19190-95
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , Issue.47 , pp. 19190-19195
    • Valentijn, L.J.1    Koster, J.2    Haneveld, F.3
  • 38
    • 79957919750 scopus 로고    scopus 로고
    • A genome-wide search for promoters that respond to increasedMYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma
    • Shohet JM, Ghosh R, Coarfa C, et al. 2011. A genome-wide search for promoters that respond to increasedMYCN reveals both new oncogenic and tumor suppressor microRNAs associated with aggressive neuroblastoma. Cancer Res. 71:3841-51
    • (2011) Cancer Res. , vol.71 , pp. 3841-3851
    • Shohet, J.M.1    Ghosh, R.2    Coarfa, C.3
  • 40
    • 0030925596 scopus 로고    scopus 로고
    • Regulation of the neural crest cell fate by N-myc: Promotion of ventral migration and neuronal differentiation
    • Wakamatsu Y, Watanabe Y, Nakamura H, Kondoh H. 1997. Regulation of the neural crest cell fate by N-myc: promotion of ventral migration and neuronal differentiation. Development 124:1953-62
    • (1997) Development , vol.124 , pp. 1953-1962
    • Wakamatsu, Y.1    Watanabe, Y.2    Nakamura, H.3    Kondoh, H.4
  • 41
    • 70449727603 scopus 로고    scopus 로고
    • Antitumor activity of the selectiveMDM2antagonist nutlin-3 against chemoresistant neuroblastoma with wild-Type p53
    • Van MaerkenT, Ferdinande L, Taildeman J, et al. 2009. Antitumor activity of the selectiveMDM2antagonist nutlin-3 against chemoresistant neuroblastoma with wild-Type p53. J. Natl. Cancer Inst. 101:1562-74
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 1562-1574
    • Van Maerken, T.1    Ferdinande, L.2    Taildeman, J.3
  • 42
    • 33749564973 scopus 로고    scopus 로고
    • MDM2 inhibition sensitizes neuroblastoma to chemotherapyinduced apoptotic cell death
    • Barbieri E, Mehta P, Chen Z, et al. 2006. MDM2 inhibition sensitizes neuroblastoma to chemotherapyinduced apoptotic cell death. Mol. Cancer Ther. 5:2358-65
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2358-2365
    • Barbieri, E.1    Mehta, P.2    Chen, Z.3
  • 43
    • 70349690458 scopus 로고    scopus 로고
    • Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma
    • Evageliou NF, Hogarty MD. 2009. Disrupting polyamine homeostasis as a therapeutic strategy for neuroblastoma. Clin. Cancer Res. 15:5956-61
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5956-5961
    • Evageliou, N.F.1    Hogarty, M.D.2
  • 44
    • 84895743330 scopus 로고    scopus 로고
    • Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: A children's oncology group study
    • Bagatell R, Norris R, Ingle AM, et al. 2014. Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: a Children's Oncology Group Study. Pediatr. Blood Cancer 61:833-39
    • (2014) Pediatr. Blood Cancer , vol.61 , pp. 833-839
    • Bagatell, R.1    Norris, R.2    Ingle, A.M.3
  • 45
    • 84891624988 scopus 로고    scopus 로고
    • Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma: A European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study
    • Di Giannatale A, Dias-GastellierN, Devos A, et al. 2014. Phase II study of temozolomide in combination with topotecan (TOTEM) in relapsed or refractory neuroblastoma: a European Innovative Therapies for Children with Cancer-SIOP-European Neuroblastoma study. Eur. J. Cancer 50:170-77
    • (2014) Eur. J. Cancer , vol.50 , pp. 170-177
    • Di Giannatale, A.1    Dias-Gastelliern Devos, A.2
  • 46
    • 77953523121 scopus 로고    scopus 로고
    • Recent advances in neuroblastoma
    • Maris JM. 2010. Recent advances in neuroblastoma. N. Engl. J. Med. 362:2202-11
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2202-2211
    • Maris, J.M.1
  • 47
    • 78049353081 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase: Role in specific tumours, and development of small molecule inhibitors for cancer therapy
    • Ardini E, Magnaghi P, Orsini P, et al. 2010. Anaplastic lymphoma kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy. Cancer Lett. 299:81-94
    • (2010) Cancer Lett. , vol.299 , pp. 81-94
    • Ardini, E.1    Magnaghi, P.2    Orsini, P.3
  • 48
    • 54049094708 scopus 로고    scopus 로고
    • Identification of ALK as amajor familial neuroblastoma predisposition gene
    • Mosse YP, Laudenslager M, Longo L, et al. 2008. Identification of ALK as amajor familial neuroblastoma predisposition gene. Nature 455:930-35
    • (2008) Nature , vol.455 , pp. 930-935
    • Mosse, Y.P.1    Laudenslager, M.2    Longo, L.3
  • 50
    • 84890878644 scopus 로고    scopus 로고
    • Target therapy in NSCLC patients: Relevant clinical agents and tumour molecular characterisation
    • Ulivi P, Zoli W, Capelli L, et al. 2013. Target therapy in NSCLC patients: relevant clinical agents and tumour molecular characterisation. Mol. Clin. Oncol. 1:575-81
    • (2013) Mol. Clin. Oncol. , vol.1 , pp. 575-581
    • Ulivi, P.1    Zoli, W.2    Capelli, L.3
  • 51
    • 80053992292 scopus 로고    scopus 로고
    • Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition
    • Reiff T, Huber L, Kramer M, et al. 2011. Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition. Development 138:4699-708
    • (2011) Development , vol.138 , pp. 4699-4708
    • Reiff, T.1    Huber, L.2    Kramer, M.3
  • 52
    • 84880350124 scopus 로고    scopus 로고
    • ALK amplification and protein expression predict inferior prognosis in neuroblastomas
    • Wang M, Zhou C, SunQ, et al. 2013. ALK amplification and protein expression predict inferior prognosis in neuroblastomas. Exp. Mol. Pathol. 95:124-30
    • (2013) Exp. Mol. Pathol. , vol.95 , pp. 124-130
    • Wang, M.1    Zhou, C.2    Sun, Q.3
  • 53
    • 84874760668 scopus 로고    scopus 로고
    • MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells
    • Schulte JH, Lindner S, Bohrer A, et al. 2013. MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells. Oncogene 32:1059-65
    • (2013) Oncogene , vol.32 , pp. 1059-1065
    • Schulte, J.H.1    Lindner, S.2    Bohrer, A.3
  • 54
    • 4544265599 scopus 로고    scopus 로고
    • Germline PHOX2B mutation in hereditary neuroblastoma
    • Mosse YP, Laudenslager M, Khazi D, et al. 2004. Germline PHOX2B mutation in hereditary neuroblastoma. Am. J. Hum. Genet. 75:727-30
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 727-730
    • Mosse, Y.P.1    Laudenslager, M.2    Khazi, D.3
  • 55
    • 12144291333 scopus 로고    scopus 로고
    • Germlinemutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma
    • TrochetD, Bourdeaut F, Janoueix-Lerosey I, et al. 2004. Germlinemutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. Am. J. Hum. Genet. 74:761-64
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 761-764
    • Trochet, D.1    Bourdeaut, F.2    Janoueix-Lerosey, I.3
  • 56
    • 84879619673 scopus 로고    scopus 로고
    • Distinct neuroblastoma-Associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models
    • PeiD, LutherW, WangW, et al. 2013. Distinct neuroblastoma-Associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models. PLOS Genet. 9:e1003533
    • (2013) PLOS Genet. , vol.9 , pp. e1003533
    • Pei, D.1    Luther, W.2    Wang, W.3
  • 57
    • 84879415727 scopus 로고    scopus 로고
    • The developmental etiology and pathogenesis of Hirschsprung disease
    • Butler Tjaden NE, Trainor PA. 2013. The developmental etiology and pathogenesis of Hirschsprung disease. Transl. Res. 162:1-15
    • (2013) Transl. Res. , vol.162 , pp. 1-15
    • Butler Tjaden, N.E.1    Trainor, P.A.2
  • 58
    • 84869018090 scopus 로고    scopus 로고
    • Transcriptional dysregulation and impairment of PHOX2B auto-regulatorymechanism induced by polyalanine expansion mutations associated with congenital central hypoventilation syndrome
    • Di Lascio S, Bachetti T, Saba E, et al. 2013. Transcriptional dysregulation and impairment of PHOX2B auto-regulatorymechanism induced by polyalanine expansion mutations associated with congenital central hypoventilation syndrome. Neurobiol. Dis. 50:187-200
    • (2013) Neurobiol. Dis. , vol.50 , pp. 187-200
    • Di Lascio, S.1    Bachetti, T.2    Saba, E.3
  • 59
    • 84908029880 scopus 로고    scopus 로고
    • Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma
    • Wang W, Zhong Q, Teng L, et al. 2013. Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma. Oncogene 33(25):3316-24
    • (2013) Oncogene , vol.33 , Issue.25 , pp. 3316-3324
    • Wang, W.1    Zhong, Q.2    Teng, L.3
  • 60
    • 78049298226 scopus 로고    scopus 로고
    • PHOX2B-mediated regulation of ALK expression: In vitro identification of a functional relationship between two genes involved in neuroblastoma
    • Bachetti T, Di Paolo D, Di Lascio S, et al. 2010. PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma. PLOS ONE 1:5(10)
    • (2010) PLOS ONE , vol.1 , Issue.5 , pp. 10
    • Bachetti, T.1    Di Paolo, D.2    Di Lascio, S.3
  • 61
    • 84885119150 scopus 로고    scopus 로고
    • An epigenetic signature of developmental potential in neural stem cells and early neurons
    • Burney MJ, Johnston C, Wong KY, et al. 2013. An epigenetic signature of developmental potential in neural stem cells and early neurons. Stem Cells 31:1868-80
    • (2013) Stem Cells , vol.31 , pp. 1868-1880
    • Burney, M.J.1    Johnston, C.2    Wong, K.Y.3
  • 62
    • 84868484735 scopus 로고    scopus 로고
    • Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest
    • Rada-Iglesias A, Bajpai R, Prescott S, et al. 2012. Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell Stem Cell 11:633-48
    • (2012) Cell Stem Cell , vol.11 , pp. 633-648
    • Rada-Iglesias, A.1    Bajpai, R.2    Prescott, S.3
  • 63
    • 33749259257 scopus 로고    scopus 로고
    • Critical role of Brg1 member of the SWI/SNFchromatin remodeling complex during neurogenesis and neural crest induction in zebrafish
    • ErogluB, WangG, TuN, et al. 2006. Critical role of Brg1 member of the SWI/SNFchromatin remodeling complex during neurogenesis and neural crest induction in zebrafish. Dev. Dyn. 235:2722-35
    • (2006) Dev. Dyn. , vol.235 , pp. 2722-2735
    • Eroglu, B.1    Wang, G.2    Tu, N.3
  • 64
    • 84930486044 scopus 로고    scopus 로고
    • Role of DNMT3B in the regulation of early neural and neural crest specifiers
    • Martins-Taylor K, Schroeder DI, LaSalle JM, et al. 2012. Role of DNMT3B in the regulation of early neural and neural crest specifiers. Epigenetics 7:71-82
    • (2012) Epigenetics , vol.7 , pp. 71-82
    • Martins-Taylor, K.1    Schroeder, D.I.2    Lasalle, J.M.3
  • 65
    • 84866390172 scopus 로고    scopus 로고
    • TruncatedDNMT3BisoformDNMT3B7suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma
    • OstlerKR, Yang Q, Looney TJ, et al. 2012. TruncatedDNMT3BisoformDNMT3B7suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma. Cancer Res. 72:4714-23
    • (2012) Cancer Res. , vol.72 , pp. 4714-4723
    • Ostler, K.R.1    Yang, Q.2    Looney, T.J.3
  • 66
    • 84872015424 scopus 로고    scopus 로고
    • Single-cell analysis of Daxx and ATRX-dependent transcriptional repression
    • Newhart A, Rafalska-Metcalf IU, Yang T, et al. 2012. Single-cell analysis of Daxx and ATRX-dependent transcriptional repression. J. Cell Sci. 125:5489-501
    • (2012) J. Cell Sci. , vol.125 , pp. 5489-5501
    • Newhart, A.1    Rafalska-Metcalf, I.U.2    Yang, T.3
  • 67
    • 84858248558 scopus 로고    scopus 로고
    • Association of age at diagnosis and genetic mutations in patients with neuroblastoma
    • Cheung NK, Zhang J, Lu C, et al. 2012. Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA 307:1062-71
    • (2012) JAMA , vol.307 , pp. 1062-1071
    • Cheung, N.K.1    Zhang, J.2    Lu, C.3
  • 68
    • 77649275464 scopus 로고    scopus 로고
    • MiR-9, a MYC/MYCN-Activated microRNA, regulates E-cadherin and cancer metastasis
    • MaL, Young J, Prabhala H, et al. 2010. miR-9, a MYC/MYCN-Activated microRNA, regulates E-cadherin and cancer metastasis. Nat. Cell Biol. 12:247-56
    • (2010) Nat. Cell Biol. , vol.12 , pp. 247-256
    • Ma, L.1    Young, J.2    Prabhala, H.3
  • 69
    • 84868210731 scopus 로고    scopus 로고
    • LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
    • Molenaar JJ, Domingo-Fernandez R, Ebus ME, et al. 2012. LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat. Genet. 44(11):1199-206
    • (2012) Nat. Genet. , vol.44 , Issue.11 , pp. 1199-1206
    • Molenaar, J.J.1    Domingo-Fernandez, R.2    Ebus, M.E.3
  • 70
    • 78649941638 scopus 로고    scopus 로고
    • The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma
    • Mestdagh P, Bostrom AK, Impens F, et al. 2010. The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma. Mol. Cell 40:762-73
    • (2010) Mol. Cell , vol.40 , pp. 762-773
    • Mestdagh, P.1    Bostrom, A.K.2    Impens, F.3
  • 71
    • 84887641104 scopus 로고    scopus 로고
    • Identification of a pan-cancer oncogenicmicroRNA superfamily anchored by a central core seed motif
    • Hamilton MP, Rajapakshe K, Hartig SM, et al. 2013. Identification of a pan-cancer oncogenicmicroRNA superfamily anchored by a central core seed motif. Nat. Commun. 4:2730:1-13
    • (2013) Nat. Commun. , vol.4 , Issue.2730 , pp. 1-13
    • Hamilton, M.P.1    Rajapakshe, K.2    Hartig, S.M.3
  • 72
    • 84867659168 scopus 로고    scopus 로고
    • N-myc and noncoding RNAs in neuroblastoma
    • Buechner J, EinvikC. 2012. N-myc and noncoding RNAs in neuroblastoma. Mol. Cancer Res. 10(10):1243-53
    • (2012) Mol. Cancer Res. , vol.10 , Issue.10 , pp. 1243-1253
    • Buechner, J.1    Einvik, C.2
  • 73
    • 84880062835 scopus 로고    scopus 로고
    • Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma
    • Ara T, Nakata R, Sheard MA, et al. 2013. Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma. Cancer Res. 73:3852-64
    • (2013) Cancer Res. , vol.73 , pp. 3852-3864
    • Ara, T.1    Nakata, R.2    Sheard, M.A.3
  • 74
    • 84861801527 scopus 로고    scopus 로고
    • IL-15 protects NKT cells from inhibition by tumor-Associated macrophages and enhances antimetastatic activity
    • Liu D, Song L, Wei J, et al. 2012. IL-15 protects NKT cells from inhibition by tumor-Associated macrophages and enhances antimetastatic activity. J. Clin. Invest. 122:2221-33
    • (2012) J. Clin. Invest. , vol.122 , pp. 2221-2233
    • Liu, D.1    Song, L.2    Wei, J.3
  • 75
    • 84867397866 scopus 로고    scopus 로고
    • Segmental chromosomal alterations have prognostic impact in neuroblastoma: A report from the INRG project
    • Schleiermacher G, Mosseri V, London WB, et al. 2012. Segmental chromosomal alterations have prognostic impact in neuroblastoma: a report from the INRG project. Br. J. Cancer 107:1418-22
    • (2012) Br. J. Cancer , vol.107 , pp. 1418-1422
    • Schleiermacher, G.1    Mosseri, V.2    London, W.B.3
  • 76
    • 0024247485 scopus 로고
    • International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma
    • Brodeur GM, Seeger RC, Barrett A, et al. 1988. International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. J. Clin. Oncol. 6:1874-81
    • (1988) J. Clin. Oncol. , vol.6 , pp. 1874-1881
    • Brodeur, G.M.1    Seeger, R.C.2    Barrett, A.3
  • 77
    • 84861668164 scopus 로고    scopus 로고
    • Neuroblastoma: The impact of biology and cooperation leading to personalized treatments
    • Owens C, IrwinM. 2012. Neuroblastoma: the impact of biology and cooperation leading to personalized treatments. Crit. Rev. Clin. Lab. Sci. 49:85-115
    • (2012) Crit. Rev. Clin. Lab. Sci. , vol.49 , pp. 85-115
    • Owens, C.1    Irwin, M.2
  • 78
    • 58249093955 scopus 로고    scopus 로고
    • The international neuroblastoma risk group (inrg) classification system: An inrg task force report
    • Cohn SL, Pearson AD, London WB, et al. 2009. The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J. Clin. Oncol. 27:289-97
    • (2009) J. Clin. Oncol. , vol.27 , pp. 289-297
    • Cohn, S.L.1    Pearson, A.D.2    London, W.B.3
  • 79
    • 84880313396 scopus 로고    scopus 로고
    • Current and future strategies for relapsed neuroblastoma: Challenges on the road to precision therapy
    • Morgenstern DA, Baruchel S, IrwinMS. 2013. Current and future strategies for relapsed neuroblastoma: challenges on the road to precision therapy. J. Pediatr. Hematol. Oncol. 35:337-47
    • (2013) J. Pediatr. Hematol. Oncol. , vol.35 , pp. 337-347
    • Morgenstern, D.A.1    Baruchel, S.2    Irwin, M.S.3
  • 81
    • 84890850147 scopus 로고    scopus 로고
    • Advances in chimeric antigen receptor immunotherapy for neuroblastoma
    • Heczey A, Louis CU. 2013. Advances in chimeric antigen receptor immunotherapy for neuroblastoma. Discov. Med. 16:287-94
    • (2013) Discov. Med. , vol.16 , pp. 287-294
    • Heczey, A.1    Louis, C.U.2
  • 82
    • 77957358855 scopus 로고    scopus 로고
    • Outcome after reduced chemotherapy for intermediate-risk neuroblastoma
    • BakerDL, SchmidtML, Cohn SL, et al. 2010. Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N. Engl. J. Med. 363:1313-23
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1313-1323
    • Baker, D.L.1    Schmidt, M.L.2    Cohn, S.L.3
  • 83
    • 41149137119 scopus 로고    scopus 로고
    • Localized infant neuroblastomas often show spontaneous regression: Results of the prospective trials NB95-S and NB97
    • Hero B, SimonT, Spitz R, et al. 2008. Localized infant neuroblastomas often show spontaneous regression: results of the prospective trials NB95-S and NB97. J. Clin. Oncol. 26:1504-10
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1504-1510
    • Hero, B.1    Simon, T.2    Spitz, R.3
  • 84
    • 79952094688 scopus 로고    scopus 로고
    • Excellent outcome with reduced treatment in infants with nonmetastatic and unresectable neuroblastoma without MYCN amplification: Results of the prospective INES 99.1
    • RubieH, De Bernardi B, Gerrard M, et al. 2011. Excellent outcome with reduced treatment in infants with nonmetastatic and unresectable neuroblastoma without MYCN amplification: results of the prospective INES 99.1. J. Clin. Oncol. 29:449-55
    • (2011) J. Clin. Oncol. , vol.29 , pp. 449-455
    • Rubie, H.1    De Bernardi, B.2    Gerrard, M.3
  • 85
    • 58749083347 scopus 로고    scopus 로고
    • Significance of MYCN amplification in international neuroblastoma staging system stage 1 and 2 neuroblastoma: A report from the International Neuroblastoma Risk Group database
    • Bagatell R, Beck-Popovic M, London WB, et al. 2009. Significance of MYCN amplification in international neuroblastoma staging system stage 1 and 2 neuroblastoma: a report from the International Neuroblastoma Risk Group database. J. Clin. Oncol. 27:365-70
    • (2009) J. Clin. Oncol. , vol.27 , pp. 365-370
    • Bagatell, R.1    Beck-Popovic, M.2    London, W.B.3
  • 87
    • 0031901264 scopus 로고    scopus 로고
    • Successful treatment of stage III neuroblastoma based on prospective biologic staging: A Children's Cancer Group study
    • Matthay KK, Perez C, Seeger RC, et al. 1998. Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study. J. Clin. Oncol. 16:1256-64
    • (1998) J. Clin. Oncol. , vol.16 , pp. 1256-1264
    • Matthay, K.K.1    Perez, C.2    Seeger, R.C.3
  • 88
    • 0033966153 scopus 로고    scopus 로고
    • Favorable biology and outcome of stage IV-S neuroblastoma with supportive care or minimal therapy: A Children's Cancer Group study
    • Nickerson HJ, Matthay KK, Seeger RC, et al. 2000. Favorable biology and outcome of stage IV-S neuroblastoma with supportive care or minimal therapy: a Children's Cancer Group study. J. Clin. Oncol. 18:477-86
    • (2000) J. Clin. Oncol. , vol.18 , pp. 477-486
    • Nickerson, H.J.1    Matthay, K.K.2    Seeger, R.C.3
  • 89
    • 77957341503 scopus 로고    scopus 로고
    • Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma
    • Yu AL, Gilman AL, Ozkaynak MF, et al. 2010. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N. Engl. J. Med. 363:1324-34
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1324-1334
    • Yu, A.L.1    Gilman, A.L.2    Ozkaynak, M.F.3
  • 90
    • 84921396797 scopus 로고    scopus 로고
    • Long-Term infusion of ch14-18/CHO combined with s.c interleukin-2 applied in a single center treatment program effectively stimulates anti-neuroblastoma activity with reduced pain in high-risk neuroblastoma patients
    • Endres S. 2014. Long-Term infusion of ch14-18/CHO combined with s.c. interleukin-2 applied in a single center treatment program effectively stimulates anti-neuroblastoma activity with reduced pain in high-risk neuroblastoma patients. Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne.
    • (2014) Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne.
    • Endres, S.1
  • 91
    • 84921396796 scopus 로고    scopus 로고
    • Myeloablative therapy (MAT) and immunotherapy (IT) with ch14.18/CHO for high risk neuroblastoma: Update and news of randomised results from the HR-NBL1/SIOPEN trial
    • Ladenstein R. 2014. Myeloablative therapy (MAT) and immunotherapy (IT) with ch14.18/CHO for high risk neuroblastoma: update and news of randomised results from the HR-NBL1/SIOPEN trial. Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne
    • (2014) Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne
    • Ladenstein, R.1
  • 92
    • 46049096104 scopus 로고    scopus 로고
    • The prognostic impact of functional imaging with 123I-mIBG in patients with stage 4 neuroblastoma >1 year of age on a high-risk treatment protocol: Results of the German Neuroblastoma Trial NB97
    • SchmidtM, Simon T, Hero B, et al. 2008. The prognostic impact of functional imaging with 123I-mIBG in patients with stage 4 neuroblastoma >1 year of age on a high-risk treatment protocol: results of the German Neuroblastoma Trial NB97. Eur. J. Cancer 44:1552-58
    • (2008) Eur. J. Cancer , vol.44 , pp. 1552-1558
    • Schmidt, M.1    Simon, T.2    Hero, B.3
  • 93
    • 0038013985 scopus 로고    scopus 로고
    • Correlation of early metastatic response by 123Imetaiodobenzylguanidine scintigraphy with overall response and event-free survival in stage IV neuroblastoma
    • Matthay KK, Edeline V, Lumbroso J, et al. 2003. Correlation of early metastatic response by 123Imetaiodobenzylguanidine scintigraphy with overall response and event-free survival in stage IV neuroblastoma. J. Clin. Oncol. 21:2486-91
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2486-2491
    • Matthay, K.K.1    Edeline, V.2    Lumbroso, J.3
  • 94
    • 67349179161 scopus 로고    scopus 로고
    • Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and qrt-pcr: Recommendations by the international neuroblastoma risk group task force.br
    • Beiske K, Burchill SA, Cheung IY, et al. 2009. Consensus criteria for sensitive detection of minimal neuroblastoma cells in bone marrow, blood and stem cell preparations by immunocytology and QRT-PCR: recommendations by the International Neuroblastoma Risk Group Task Force.Br. J. Cancer 100:1627-37
    • (2009) J. Cancer , vol.100 , pp. 1627-1637
    • Beiske, K.1    Burchill, S.A.2    Cheung, I.Y.3
  • 95
    • 84921396795 scopus 로고    scopus 로고
    • Generation and administration of autologous T cells transduced with a 3rd generation GD2 chimeric antigen receptor for patients with relapsed or refractory neuroblastoma
    • Modak S. 2014. Generation and administration of autologous T cells transduced with a 3rd generation GD2 chimeric antigen receptor for patients with relapsed or refractory neuroblastoma. Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne
    • (2014) Presented at Advances in Neuroblastoma Res. Conf. (ANR2014), Cologne
    • Modak, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.