Mammalian cytochrome P450 enzymes catalyze the phenol-coupling step in endogenous morphine biosynthesis

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24425-24431

  Grobe, Nadja ^a   Zhang, Baichen ^a   Fisinger, Ursula ^b   Kutchan, Toni M ^a   Zenk, Meinhart H ^a   Guengerich, F Peter ^c  

^a DONALD DANFORTH PLANT SCIENCE CENTER   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN TISSUE; CATALYTIC EFFICIENCIES; CONCENTRATION OF; COUPLING REACTION; CYTOCHROME B; CYTOCHROME P450; HETEROCYCLES; HUMAN NEUROBLASTOMA; IRON OXIDATION; MORPHINE BIOSYNTHESIS; SINGLE CYCLE; SINGLE PRODUCT; TOTAL YIELD;

ANIMAL CELL CULTURE; BIOCHEMISTRY; CATALYSTS; CELL CULTURE; CELL MEMBRANES; ENZYMES; MAMMALS; SUBSTRATES;

PHENOLS;

ALKALOID; CORYTUBERINE; CYTOCHROME B5; CYTOCHROME P450; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; ENDORPHIN; IRON; ISOBOLDINE; PALLIDINE; PHENOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RETICULINE; SALUTARIDIN; SINOACUTINE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; BRAIN TISSUE; CATALYSIS; CONTROLLED STUDY; NEUROBLASTOMA CELL; NONHUMAN; OXIDATION; PAPAVER SOMNIFERUM; PRIORITY JOURNAL;

ANIMALS; BENZYLISOQUINOLINES; CATALYSIS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; HUMANS; IRON; MICE; MORPHINANS; MORPHINE; OXIDATION-REDUCTION; PHENOLS; RATS;

MAMMALIA; MUS; PAPAVER; SUS;

EID: 69949188699     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.011320     Document Type: Article

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