Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range 7 Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase

Journal of Biological Chemistry

Volumn 291, Issue 19, 2016, Pages 10078-10088

  Deredge, Daniel ^a   Li, Jiawen ^b   Johnson, Kenneth A ^a,b   Wintrode, Patrick L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; ELONGATION; ENZYMES; HYDROGEN; KINETICS;

ALLOSTERIC EFFECT; ALLOSTERIC INHIBITOR; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; EXCHANGE KINETICS; HYDROGEN/DEUTERIUM EXCHANGE; STRUCTURAL REARRANGEMENT; VIRAL INFECTIONS;

RNA;

FILIBUVIR; LOMIBUVIR; NONSTRUCTURAL PROTEIN 5B; RNA DIRECTED RNA POLYMERASE; FURAN DERIVATIVE; GS-9669; NS-5 PROTEIN, HEPATITIS C VIRUS; PYRONE DERIVATIVE; THIOPHENE DERIVATIVE; TRIAZOLE DERIVATIVE; VIRAL PROTEIN; VIRUS RNA;

ALPHA HELIX; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING SITE; ENZYME KINETICS; HEPATITIS C VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN UNFOLDING; RNA BINDING; RNA SYNTHESIS; ALLOSTERISM; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DEUTERIUM HYDROGEN EXCHANGE; DRUG EFFECT; ENZYMOLOGY; HEPACIVIRUS; KINETICS;

ALLOSTERIC REGULATION; BINDING SITES; DEUTERIUM EXCHANGE MEASUREMENT; FURANS; HEPACIVIRUS; KINETICS; PYRONES; RNA REPLICASE; RNA, VIRAL; THIOPHENES; TRIAZOLES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84966340081     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.708370     Document Type: Article

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