Allosteric inhibition of complement function by a staphylococcal immune evasion protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 41, 2010, Pages 17621-17626

  Chen, Hui ^a   Ricklin, Daniel ^a   Hammel, Michal ^b   Garcia, Brandon L ^c   McWhorter, William J ^c   Sfyroera, Georgia ^a   Wu, You Qiang ^a   Tzekou, Apostolia ^a   Li, Sheng ^d   Geisbrecht, Brian V ^c   Woods Jr , Virgil L ^d   Lambris, John D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Allosteric modulation; Complement amplification; Hydrogen deuterium exchange mass spectrometry; Small angle X ray scattering; Surface plasmon resonance

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; BINDING PROTEIN; COMPLEMENT COMPONENT C3B; EXTRACELLULAR FIBRINOGEN BINDING PROTEIN; EXTRACELLULAR FIBRINOGEN BINDING PROTEIN C; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; COMPLEMENT SYSTEM; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS;

ALLOSTERIC REGULATION; BACTERIAL PROTEINS; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT C3B; COMPLEMENT FACTOR B; COMPLEMENT INACTIVATOR PROTEINS; IMMUNE EVASION; MASS SPECTROMETRY; MODELS, MOLECULAR; PROTEIN CONFORMATION; SCATTERING, SMALL ANGLE; STAPHYLOCOCCUS AUREUS; SURFACE PLASMON RESONANCE;

STAPHYLOCOCCUS AUREUS;

EID: 78049233405     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003750107     Document Type: Article

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