Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor

Biochemistry

Volumn 54, Issue 41, 2015, Pages 6382-6391

  Wales, Thomas E ^a   Hochrein, James M ^a,c   Morgan, Christopher R ^a,d   Emert Sedlak, Lori A ^b   Smithgall, Thomas E ^b   Engen, John R ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c SANDIA NATIONAL LABORATORIES   (United States)

^d GENZYME CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; CELL SIGNALING; CHEMICAL ACTIVATION; CONFORMATIONS; ENZYME INHIBITION; MASS SPECTROMETRY;

BIOCHEMICAL ASSAY; CHEMICAL LIBRARIES; CONFORMATIONAL CHANGE; CONFORMATIONAL DYNAMICS; HYDROGEN EXCHANGE; KINASE ACTIVATION; KINASE INHIBITORS; REGULATORY INTERACTIONS;

ENZYMES;

ANTIRETROVIRUS AGENT; DEUTERIUM; HEMATOPOIETIC CELL KINASE; NEF PROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN SH2; PROTEIN SH3; RECOMBINANT PROTEIN; VIRULENCE FACTOR; HCK PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROGEN EXCHANGE MASS SPECTROMETRY; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; HIV INFECTIONS; METABOLISM; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SRC HOMOLOGY DOMAIN;

ENZYME ACTIVATION; HIV INFECTIONS; HIV-1; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-HCK; SRC HOMOLOGY DOMAINS; VIRUS REPLICATION;

EID: 84945393213     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00875     Document Type: Article

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