Structural basis for RNA replication by the hepatitis C virus polymerase

Science

Volumn 347, Issue 6223, 2015, Pages 771-775

  Appleby, Todd C ^a   Perry, Jason K ^a   Murakami, Eisuke ^a   Barauskas, Ona ^a   Feng, Joy ^a   Cho, Aesop ^a   Fox, David ^b   Wetmore, Diana R ^b   McGrath, Mary E ^a   Ray, Adrian S ^a   Sofia, Michael J ^a   Swaminathan, S ^a   Edwards, Thomas E ^b  

^a GILEAD SCIENCES   (United States)

^b Beryllium   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METAL ION; NONSTRUCTURAL PROTEIN 5B; NUCLEOTIDE; PRIMER RNA; RNA POLYMERASE; SOFOSBUVIR; VIRUS RNA; 2-((5-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-4-FLUORO-3-HYDROXY-4-METHYLTETRAHYDROFURAN-2-YLMETHOXY)PHENOXYPHOSPHORYLAMINO)PROPIONIC ACID ISOPROPYL ESTER; NS-5 PROTEIN, HEPATITIS C VIRUS; RIBONUCLEOTIDE; RNA DIRECTED RNA POLYMERASE; URIDINE PHOSPHATE; VIRUS PROTEIN;

CHEMICAL BINDING; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC MARKER; GENOME; INHIBITOR; METABOLITE; RNA; VIRUS;

ARTICLE; CRYSTAL STRUCTURE; HEPATITIS C; HEPATITIS C VIRUS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; RNA REPLICATION; RNA SYNTHESIS; VIRUS GENOME; VIRUS REPLICATION; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HEPACIVIRUS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

HEPATITIS C VIRUS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RIBONUCLEOTIDES; RNA REPLICASE; RNA, VIRAL; URIDINE MONOPHOSPHATE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84923103825     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1259210     Document Type: Article

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