Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 13, 2012, Pages 4288-4292

  Canales, Eda ^a   Carlson, Joseph S ^a,e   Appleby, Todd ^b   Fenaux, Martijn ^c,f   Lee, Johnny ^d   Tian, Yang ^d   Tirunagari, Neeraj ^d   Wong, Melanie ^c   Watkins, William J ^a  

^a Medicinal Chemistry Department   (United States)

^b Structural Chemistry Department   (United States)

^c Gilead Sciences   (United States)

^d High Throughput Biology Department   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Novartis Inc   (United States)

Author keywords

Amide bioisostere; HCV; Hydrazine; PDB; Thumb

Indexed keywords

ANTIVIRUS AGENT; ENZYME INHIBITOR; HYDRAZINE DERIVATIVE; NONSTRUCTURAL PROTEIN 5B; NONSTRUCTURAL PROTEIN 5B POLYMERASE INHIBITOR DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG POTENCY; DRUG STRUCTURE; HEPATITIS C; HEPATITIS C VIRUS; IC 50; PHYSICAL CHEMISTRY; SUBSTITUTION REACTION;

AMIDES; ANTIVIRAL AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; ENZYME INHIBITORS; HEPACIVIRUS; HUMANS; HYDRAZINES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84862236586     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.025     Document Type: Article

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